The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization
Open accessAbstract
The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid beta protein (Abeta) can be targeted in a similar manner to animal cell-derived or synthetic Abeta. Because the structure of Abeta depends on its source and the presence of cofactors, it is of great interest to determine whether human-derived oligomeric Abeta species impair brain function and, if so, whether or not their disruptive effects can be prevented using antibodies. We report that untreated ex vivo human CSF that contains Abeta dimers rapidly inhibits hippocampal long-term potentiation in vivo and that acute systemic infusion of an anti-Abeta monoclonal antibody can prevent this disruption of synaptic plasticity. Abeta monomer isolated from human CSF did not affect long-term potentiation. These results strongly support a strategy of passive immunization against soluble Abeta oligomers in early Alzheimer's disease.
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“Small oligomers obtained from AD-affected human brain also are active in plasticity assays (Barry et al., 2011; Klyubin et al., 2008; Li et al., 2011).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Klyubin et al., 2008
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1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1×
“Although it is possible that A dimers in human CSF may form larger assemblies such as A *56 (molecular weight, 56 kDa), which has been found in the brains of APP transgenic mice (Lesné et al., 2006), we failed to detect such species in the human CSF samples by IP/Western blot or SEC/Western blot.”
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Self-citationImmunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
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Self-citationAβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431
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Bigi, A., Napolitano, L., Vadukul, D. M., Chiti, F., Cecchi, C., Aprile, F. A., & Cascella, R. (2024) · Figshare · doi:10.6084/m9.figshare.25025878
Rofo, F., Buijs, J., Falk, R., Honek, K., Lannfelt, L., Lilja, A. M., Metzendorf, N. G., Gustavsson, T., Sehlin, D., Söderberg, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16689644
Physiological and pathological roles of the amyloid precursor protein at the presynapse
Jordá-Siquier, T. (2021) · theses.fr (ABES) · doi:10.70675/3bff9a77z3935z4d28zb02bz5b454bcbc77e
Borcuk, C. (2021) · theses.fr (ABES) · doi:10.70675/c316f2dcz54d3z41cfzb3f5z99c7b2d3cd95 · Cited by 1
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.05
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.references
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.07
Third Section: Design of a dimeric-nanobody specific for Aβ42 oligomers: the Dimeric-DesAb-O
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.06
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.03
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.04
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.02
Conclusion and Future Perspectives
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.08
Controversies in dementia research
Spires‐Jones, T. L. (2026) · Oxford University Press eBooks · doi:10.1093/9780198995296.003.0007
Streltsov, V. A., Irie, Y., Hanaki, Y., Hanaki, M., Kageyama, Y., Masters, C. L., & Irie, K. (2026) · npj Dementia · doi:10.1038/s44400-026-00118-3
BindingDB (2010) · UC San Diego · doi:10.7270/q2bk1ch7
BindingDB (2010) · UC San Diego · doi:10.7270/q2zw1kz7
Synapses and Alzheimers’s Disease: Effect of Immunotherapy?
Denham, N. C., Nicoll, J. A. R., & Boche, D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7061-9_14
Metadata
- Authors
- Klyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., Selkoe, D. J., Anwyl, R., Walsh, D. M., & Rowan, M. J.
- Affiliations
- Trinity College Dublin (IE)
- University College Dublin (IE)
- New York University (US)
- University of Gothenburg (SE)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-04-16
- Volume
- 28
- Issue
- 16
- Pages
- 4231-4237
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2685151
- OpenAlex
- W1970874743
- Cited by
- 321
- References
- 34
- Citations by year
- 2026: 13 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 15 · 2021: 12 · 2020: 15 · 2019: 11 · 2018: 13 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 35
- FWCI
- 27.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (067660)
- European Commission
- Higher Education Authority
- Science Foundation Ireland
- National Institutes of Health (AG20245)
- National Institute on Aging (AG20245, R01AG020245)
- National Institute of Neurological Disorders and Stroke (R01NS136122)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, human cerebrospinal fluid, synaptic plasticity, long-term potentiation, hippocampus, passive immunization, anti-amyloid monoclonal antibodies, Alzheimer's disease, immunotherapy, amyloid-beta oligomers
- MeSH terms
- Alzheimer Disease, Animals, Antibodies, Monoclonal, Cricetulus, Cricetinae, Humans, Immunization, Passive, Male, Neuronal Plasticity, Synapses, Amyloid beta-Peptides, CHO Cells, Rats, Wistar, Long-Term Potentiation, Dimerization, Rats
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