The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
A Critical Interaction between NR2B and MAGUK in l-DOPA Induced Dyskinesia
Open accessAbstract
Abnormal function of NMDA receptor has been suggested to be correlated with the pathogenesis of Parkinson’s disease (PD) as well as with the development of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia. Here we show that NMDA receptor NR2 subunits display specific alterations of their subcellular distribution in striata from unilateral 6-hydroxydopamine-lesioned,l-DOPA-treated dyskinetic, and l-DOPA-treated nondyskinetic rats. Dyskinetic animals have significantly higher levels of NR2A subunit in the postsynaptic compartment than all other experimental groups, whereas NR2B subunit shows a significant reduction in both dopamine-denervated and dyskinetic rats. These events are paralleled by profound modifications of NMDA receptor NR2B subunit association with interacting elements, i.e., members of the membrane-associated guanylate kinase (MAGUK) protein family postsynaptic density-95, synapse-associated protein-97 and synapse-associated protein-102. Treatment of nondyskinetic animals with a synthetic peptide (TAT2B) able to affect NR2B binding to MAGUK proteins as well as synaptic localization of this subunit in nondyskinetic rats was sufficient to induce a shift of treated rats toward a dyskinetic motor behavior. These data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in l-DOPA-induced dyskinesia.
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Cited by
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
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Functional Neuroanatomy of the Basal Ganglia
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Diversity in NMDA Receptor Composition: Many Regulators, Many Consequences
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Metadata
- Authors
- Gardoni, F., Picconi, B., Ghiglieri, V., Polli, F., Bagetta, V., Bernardi, G., Cattabeni, F., Di Luca, M., & Calabresi, P.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-03-15
- Volume
- 26
- Issue
- 11
- Pages
- 2914-2922
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1994911797
- Cited by
- 269
- References
- 34
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gardoni, F., Picconi, B., Ghiglieri, V., Polli, F., Bagetta, V., Bernardi, G., Cattabeni, F., Di Luca, M., & Calabresi, P. (2006). A Critical Interaction between NR2B and MAGUK in l-DOPA Induced Dyskinesia. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5326-05.2006
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