Cited by 263Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

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Nucleus Accumbens μ-Opioid Receptors Mediate Social Reward

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Trezza, Viviana, Damsteegt, Ruth, Achterberg, E. J. Marijke, Vanderschuren, Louk J. M. J.·2011·The Journal of Neuroscience

DOI 10.1523/jneurosci.5492-10.2011PMC PMC3098965

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Abstract

Positive social interactions are essential for emotional well-being and proper behavioral development of young individuals. Here, we studied the neural underpinnings of social reward by investigating the involvement of opioid neurotransmission in the nucleus accumbens (NAc) in social play behavior, a highly rewarding social interaction in adolescent rats. Intra-NAc infusion of morphine (0.05–0.1 μg) increased pinning and pouncing, characteristic elements of social play behavior in rats, and blockade of NAc opioid receptors with naloxone (0.5 μg) prevented the play-enhancing effects of systemic morphine (1 mg/kg, s.c.) administration. Thus, stimulation of opioid receptors in the NAc was necessary and sufficient for morphine to increase social play. Intra-NAc treatment with the selective μ-opioid receptor agonist [ d -Ala 2 , N -MePhe 4 ,Gly 5 -ol]enkephalin (DAMGO) (0.1–10 ng) and the μ-opioid receptor antagonist Cys-Tyr- d -Trp-Arg-Thr-Pen-Thr-NH 2 (CTAP) (0.3–3 μg) increased and decreased social play, respectively. The δ-opioid receptor agonist DPDPE ([ d -Pen 2 , d -Pen 5 ]-enkephalin) (0.3–3 μg) had no effects, whereas the κ-opioid receptor agonist U69593 ( N -methyl-2-phenyl- N -[(5 R ,7 S ,8 S )-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide) (0.01–1 μg) decreased social play. Intra-NAc treatment with β-endorphin (0.01–1 μg) increased social play, but met-enkephalin (0.1–5 μg) and the enkephalinase inhibitor thiorphan (0.1–1 μg) were ineffective. DAMGO (0.1–10 ng) increased social play after infusion into both the shell and core subregions of the NAc. Last, intra-NAc infusion of CTAP (3 μg) prevented the development of social play-induced conditioned place preference. These findings identify NAc μ-opioid receptor stimulation as an important neural mechanism for the attribution of positive value to social interactions in adolescent rats. Altered NAc μ-opioid receptor function may underlie social impairments in psychiatric disorders such as autism, schizophrenia, or personality disorders.

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Authors: Trezza, V., Damsteegt, R., Achterberg, E. J. M., & Vanderschuren, L. J. M. J.
Affiliations: Roma Tre University (IT)
University Medical Center Utrecht (NL)
Utrecht University (NL)
ORCID: Trezza, Viviana
Achterberg, E. J. Marijke
Vanderschuren, Louk J. M. J.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-04-27
Volume: 31
Issue: 17
Pages: 6362-6370
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5492-10.2011
PMC: PMC3098965
OpenAlex: W2161751456
Cited by: 263
References: 76
Citations by year: 2026: 11 · 2025: 16 · 2024: 15 · 2023: 15 · 2022: 22 · 2021: 15 · 2020: 21 · 2019: 15 · 2018: 22 · 2017: 12 · 2016: 24 · 2015: 19 · 2014: 14 · 2013: 26 · 2012: 12
FWCI: 7.29
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Iris (Roma Tre University) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Funders: Top Institute Pharma (T5-107)
National Institute on Drug Abuse (R01DA022628)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: nucleus accumbens, mu-opioid receptor, social reward, social play, morphine, DAMGO, CTAP, beta-endorphin, adolescent rats, conditioned place preference, opioid receptor subtypes, social behavior development, thiorphan, enkephalinase inhibition, naloxone
MeSH terms: Analgesics, Opioid, Analysis of Variance, Animals, Behavior, Animal, beta-Endorphin, Conditioning, Operant, Dose-Response Relationship, Drug, Male, Motor Activity, Narcotic Antagonists, Nucleus Accumbens, Reward, Social Behavior, Rats, Sprague-Dawley, Receptors, Opioid, mu, Neurotransmitter Agents, Rats

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Nucleus Accumbens μ-Opioid Receptors Mediate Social Reward

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