The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Chronic Consumption of a High-Fat Diet during Pregnancy Causes Perturbations in the Serotonergic System and Increased Anxiety-Like Behavior in Nonhuman Primate Offspring
Open accessAbstract
Childhood obesity is associated with increased risk of behavioral/psychological disorders including depression, anxiety, poor learning, and attention deficient disorder. As the majority of women of child-bearing age are overweight or obese and consume a diet high in dietary fat, it is critical to examine the consequences of maternal overnutrition on the development of brain circuitry that regulates offspring behavior. Using a nonhuman primate model of diet-induced obesity, we found that maternal high-fat diet (HFD) consumption caused perturbations in the central serotonergic system of fetal offspring. In addition, female infants from HFD-fed mothers exhibited increased anxiety in response to threatening novel objects. These findings have important clinical implications as they demonstrate that exposure to maternal HFD consumption during gestation, independent of obesity, increases the risk of developing behavioral disorders such as anxiety.
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Cites
Adolescent social anxiety as an outcome of inhibited temperament in childhood
SCHWARTZ, C. E., SNIDMAN, N., & KAGAN, J. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199908000-00017 · Cited by 758
Waring, M. E., & Lapane, K. L. (2008) · Pediatrics · doi:10.1542/peds.2007-1955 · Cited by 294
Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients
John Mann, J., & Malone, K. M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00217-x · Cited by 278
McCormack, K., Newman, T. K., Higley, J. D., Maestripieri, D., & Sanchez, M. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.01.009 · Cited by 161 · cited 2×
“, 1997), and enhanced stress response (McCormack et al., 2009), future studies need to examine the impact of maternal HFD consumption on neuronal development, stress response, and cognition.”
BackgroundBach-Mizrachi, H., Underwood, M. D., Tin, A., Ellis, S. P., Mann, J. J., & Arango, V (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002143 · Cited by 153
Cited by
Epigenetic and transgenerational reprogramming of brain development
Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505
Hypothalamic inflammation in obesity and metabolic disease
Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474
Ma, J., Prince, A. L., Bader, D., Hu, M., Ganu, R., Baquero, K., Blundell, P., Alan Harris, R., Frias, A. E., Grove, K. L., et al. (2014) · Nature Communications · doi:10.1038/ncomms4889 · Cited by 438
Self-citationSex differences in anxiety and emotional behavior
Donner, N. C., & Lowry, C. A. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1271-7 · Cited by 379
The role of maternal obesity in the risk of neuropsychiatric disorders
Rivera, H. M., Christiansen, K. J., & Sullivan, E. L. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00194 · Cited by 307
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Metadata
- Authors
- Sullivan, E. L., Grayson, B., Takahashi, D., Robertson, N., Maier, A., Bethea, C. L., Smith, M. S., Coleman, K., & Grove, K. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-10
- Volume
- 30
- Issue
- 10
- Pages
- 3826-3830
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2006716163
- Cited by
- 322
- References
- 5
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sullivan, E. L., Grayson, B., Takahashi, D., Robertson, N., Maier, A., Bethea, C. L., Smith, M. S., Coleman, K., & Grove, K. L. (2010). Chronic Consumption of a High-Fat Diet during Pregnancy Causes Perturbations in the Serotonergic System and Increased Anxiety-Like Behavior in Nonhuman Primate Offspring. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5560-09.2010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
