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Hippocampal Histone Acetylation Regulates Object Recognition and the Estradiol-Induced Enhancement of Object Recognition
Open accessAbstract
Histone acetylation has recently been implicated in learning and memory processes, yet necessity of histone acetylation for such processes has not been demonstrated using pharmacological inhibitors of histone acetyltransferases (HATs). As such, the present study tested whether garcinol, a potent HAT inhibitor in vitro, could impair hippocampal memory consolidation and block the memory-enhancing effects of the modulatory hormone 17β-estradiol E2. We first showed that bilateral infusion of garcinol (0.1, 1, or 10 μg/side) into the dorsal hippocampus (DH) immediately after training impaired object recognition memory consolidation in ovariectomized female mice. A behaviorally effective dose of garcinol (10 μg/side) also significantly decreased DH HAT activity. We next examined whether DH infusion of a behaviorally subeffective dose of garcinol (1 ng/side) could block the effects of DH E2 infusion on object recognition and epigenetic processes. Immediately after training, ovariectomized female mice received bilateral DH infusions of vehicle, E2 (5 μg/side), garcinol (1 ng/side), or E2 plus garcinol. Forty-eight hours later, garcinol blocked the memory-enhancing effects of E2. Garcinol also reversed the E2-induced increase in DH histone H3 acetylation, HAT activity, and levels of the de novo methyltransferase DNMT3B, as well as the E2-induced decrease in levels of the memory repressor protein histone deacetylase 2. Collectively, these findings suggest that histone acetylation is critical for object recognition memory consolidation and the beneficial effects of E2 on object recognition. Importantly, this work demonstrates that the role of histone acetylation in memory processes can be studied using a HAT inhibitor.
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“Post-sample hippocampal infusions of histone acetylase inhibitors decreased histone acetylation and impaired NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Zhao et al., 2012
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Chromatin modification and epigenetic reprogramming in mammalian development
Li, E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg887 · Cited by 1,900
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
Cooperation between Complexes that Regulate Chromatin Structure and Transcription
Narlikar, G. J., Fan, H.-Y., & Kingston, R. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00654-2 · Cited by 1,486
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227
Covalent Modification of DNA Regulates Memory Formation
Miller, C. A., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.022 · Cited by 1,220
Regulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131
Yang, X.-J., & Seto, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210599 · Cited by 940
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Molecular Mechanisms Underlying Rapid Effects of Estradiol on Memory Consolidation
Frick, K. M., Kim, J., Koss, W. A., & Tuscher, J. J. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190645908.003.0009 · Cited by 2
Zhang, D. D., Wang, Y. G., Liu, C. Y., Wang, Z. H., & Wang, Y. F. (2021) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2021-002 · Cited by 2
Kwag, E., Park, S.-J., Lee, J.-H., Lee, J.-Y., Khang, R., & Shin, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151316 · Cited by 1
Hatakeyama, D., Sunada, H., Totani, Y., Watanabe, T., Felletár, I., Fitchett, A., Eravci, M., Anagnostopoulou, A., Miki, R., Kuzuhara, T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.26.445902 · Cited by 1
Merschbaecher, K. (2013) · Publications of the UdS (Saarland University) · doi:10.22028/d291-22892
Modern Epigenetics: Potential Mechanisms for Cultural Transmission and Social Learning in Primates
Stolzenberg, D. S. (2016) · Evolution of Nervous Systems · doi:10.1016/b978-0-12-804042-3.00096-8
Daniel, J., & Beck, K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21091-2
Sheppard, P. A. S. (2018) · The Atrium (University of Guelph)
Hormonal Regulation of Object Memory Consolidation
Taxier, L. R., & Frick, K. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00032-x
Estrogenic Regulation of Synaptic Actin Proteins and Plasticity
Kramár, E. A. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190645908.003.0006
Huang, F., Xue, W., Lan, Y., Tao, Y., Zhou, J., Liu, Y., Guan, H., Shi, H., Zhang, X., Wu, X., et al. (2020) · doi:10.21203/rs.3.rs-35057/v2
Memory and Epigenetics: Role of Estrogen
Tuscher, J. J., Fortress, A. M., & Frick, K. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64551-8 · Cited by 1
Huang, F., Lan, Y., Zhou, J., Yang, L., Guan, H., Shi, H., Wu, H., Zhi-bi, H., & Wu, X. (2020) · doi:10.21203/rs.3.rs-35057/v1
Memory and epigenetics: Influence of sex and estrogens
Beamish, S. B., Tuscher, J. J., & Frick, K. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00058-3
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J., O’Neil, D. S., Aagaard, K. M., Gibson, C. L., Heery, D. M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-92938-1
Metadata
- Authors
- Zhao, Z., Fan, L., Fortress, A. M., Boulware, M. I., & Frick, K. M.
- Affiliations
- Yale University (US)
- University of Wisconsin–Milwaukee (US)
- Corresponding author
- Frick, Karyn M.
- ORCID
- Frick, Karyn M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-02-14
- Volume
- 32
- Issue
- 7
- Pages
- 2344-2351
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3401048
- OpenAlex
- W1970636571
- Cited by
- 115
- References
- 46
- Citations by year
- 2025: 3 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 11 · 2019: 10 · 2018: 12 · 2017: 6 · 2016: 16 · 2015: 8 · 2014: 12 · 2013: 16 · 2012: 3
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- University of Wisconsin-Milwaukee
- National Institute on Aging (R01AG022525, AG022525)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- histone acetylation, histone acetyltransferase inhibition, garcinol, object recognition memory, memory consolidation, estradiol, hippocampus, dorsal hippocampus, histone H3 acetylation, DNMT3B, HDAC2
- MeSH terms
- Acetylation, Animals, Estradiol, Female, Hippocampus, Histones, Mice, Inbred C57BL, Plant Extracts, Terpenes, Recognition, Psychology, Mice, Histone Acetyltransferases
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