The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
The multiple effects of amino acids on the early stages of calcium carbonate crystallization
Open accessAbstract
Proteins have found their way into many of Nature’s structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO 3 mineralization – either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO 3 crystallization. These same amino acids have been independently implicated as constituents in liquid-like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.
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“Aspartic acids in particular were shown to modify calcite crystal morphology by altering the surface energy at certain crystallographic facies.36,42−44”
From Organic Controls over Biomineral Ca-Mg Carbonate Compositions and Morphologies (2023) · cites this paper as [36]
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“Despite extensive works on the effects of amino acids on the calcium carbonate system,33−36 the effects of amino acids and chitins on Ca–Mg carbonate crystallization are poorly constrained.”
From Organic Controls over Biomineral Ca-Mg Carbonate Compositions and Morphologies (2023) · cites this paper as [36]
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Cites
THE MATERIAL BONE: Structure-Mechanical Function Relations
Weiner, S., & Wagner, H. D. (1998) · Annual Review of Materials Science · doi:10.1146/annurev.matsci.28.1.271 · Cited by 2,717
Natively unfolded proteins: A point where biology waits for physics
Uversky, V. N. (2002) · Protein Science · doi:10.1110/ps.4210102 · Cited by 1,852
Stable Prenucleation Calcium Carbonate Clusters
Gebauer, D., Völkel, A., & Cölfen, H. (2008) · Science · doi:10.1126/science.1164271 · Cited by 1,673
Self-citationMolecular biomimetics: nanotechnology through biology
Sarıkaya, M., Tamerler, C., Jen, A. K. ‐., Schulten, K. J., & Baneyx, F. (2003) · Nature Materials · doi:10.1038/nmat964 · Cited by 1,597
Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly
Whaley, S. R., English, D. S., Hu, E. L., Barbara, P. F., & Belcher, A. M. (2000) · Nature · doi:10.1038/35015043 · Cited by 1,289
Gower, L. B. (2008) · Chemical Reviews · doi:10.1021/cr800443h · Cited by 1,086
Mollusk Shell Formation: A Source of New Concepts for Understanding Biomineralization Processes
Addadi, L., Joester, D., Nudelman, F., & Weiner, S. (2006) · Chemistry – A European Journal · doi:10.1002/chem.200500980 · Cited by 1,079
Biomimetic synthesis and patterning of silver nanoparticles
Naik, R. R., Stringer, S. J., Agarwal, G., Jones, S. E., & Stone, M. O. (2002) · Nature Materials · doi:10.1038/nmat758 · Cited by 1,064
Design strategies in mineralized biological materials
Weiner, S., & Addadi, L. (1997) · Journal of Materials Chemistry · doi:10.1039/a604512j · Cited by 1,028
The Initial Stages of Template-Controlled CaCO 3 Formation Revealed by Cryo-TEM
Pouget, E. M., Bomans, P. H. H., Goos, J. A. C. M., Frederik, P. M., de With, G., & Sommerdijk, N. A. J. M. (2009) · Science · doi:10.1126/science.1169434 · Cited by 916
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- Marin F., 2007, Elsevier, 80, 209
- Hasson D., 2011, Scale Control Inhibitors: A Review Article. Ind. Eng. Chem. Res., 50, 7601
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Gao, P., Qu, A., Xia, J., Li, Q., Song, Y., & Yang, L. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7511958
Huang, W., Tang, X., Dan, B., Deng, J., Duan, W., & Zheng, C. (2026) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2026.106967
Guardado-Urbina, A. G., Loredo-Portales, R., Rosales-Hoz, M. J., Moreno, A., & Cuéllar‐Cruz, M. (2026) · Die Naturwissenschaften · doi:10.1007/s00114-026-02188-y
Metadata
- Authors
- Picker, A., Kellermeier, M., Seto, J., Gebauer, D., & Cölfen, H.
- Affiliations
- University of Konstanz (DE)
- Venue
- Zeitschrift für Kristallographie - Crystalline Materials
- Publisher
- Walter de Gruyter GmbH
- Published
- 2012-10-15
- Volume
- 227
- Issue
- 11
- Pages
- 744-757
- ISSN
- 2194-4946 (ISSN-L)
- OpenAlex
- W2143726201
- Cited by
- 103
- References
- 67
- Citations by year
- 2026: 14 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 3
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Zeitschrift für Kristallographie - Crystalline Materials (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
- Keywords
- amino acids, calcium carbonate crystallization
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