The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
The wound inflammatory response exacerbates growth of pre‐neoplastic cells and progression to cancer
Open accessAbstract
There is a long-standing association between wound healing and cancer, with cancer often described as a "wound that does not heal". However, little is known about how wounding, such as following surgery, biopsy collection or ulceration, might impact on cancer progression. Here, we use a translucent zebrafish larval model of Ras(G12V)-driven neoplasia to image the interactions between inflammatory cells drawn to a wound, and to adjacent pre-neoplastic cells. We show that neutrophils are rapidly diverted from a wound to pre-neoplastic cells and these interactions lead to increased proliferation of the pre-neoplastic cells. One of the wound-inflammation-induced trophic signals is prostaglandin E2 (PGE2). In an adult model of chronic wounding in zebrafish, we show that repeated wounding with subsequent inflammation leads to a greater incidence of local melanoma formation. Our zebrafish studies led us to investigate the innate immune cell associations in ulcerated melanomas in human patients. We find a strong correlation between neutrophil presence at sites of melanoma ulceration and cell proliferation at these sites, which is associated with poor prognostic outcome.
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Cites
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Cited by
Neutrophils in cancer: Neutral no more
Coffelt, S. B., Wellenstein, M. D., & de Visser, K. E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.52 · Cited by 1,830
Intra-tumor heterogeneity from a cancer stem cell perspective
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Neutrophils in cancer: heterogeneous and multifaceted
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Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy
Masucci, M. T., Minopoli, M., & Carriero, M. V. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01146 · Cited by 649
Neutrophils in the tumor microenvironment
Powell, D. R., & Huttenlocher, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2015.11.008 · Cited by 578
Metadata
- Authors
- Antonio, N., Bønnelykke‐Behrndtz, M. L., Ward, L. C., Collin, J., Christensen, I. J., Steiniche, T., Schmidt, H., Feng, Y., & Martin, P.
- Venue
- The EMBO Journal
- Published
- 2015-07
- Volume
- 34
- Issue
- 17
- Pages
- 2219-2236
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W1942447546
- Cited by
- 280
- References
- 68
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Antonio, N., Bønnelykke‐Behrndtz, M. L., Ward, L. C., Collin, J., Christensen, I. J., Steiniche, T., Schmidt, H., Feng, Y., & Martin, P. (2015). The wound inflammatory response exacerbates growth of pre‐neoplastic cells and progression to cancer. The EMBO Journal. https://doi.org/10.15252/embj.201490147
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
