Alpha‐ketoglutarate: a “magic” metabolite in early germ cell development
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α-KG is an important cofactor for enzymes participating in epigenetic modification.
“α-KG is considered an important cofactor for enzymes participating in epigenetic modification26.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [26]
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Self-citationMetabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate
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Glutamine reliance in cell metabolism
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“…of the tricarboxylate cycle (TCA cycle) and amino acid metabolic pathway [63], which was a “ magic ” metabolite involved in delaying aging [64], protection against oxidative stress [65], early germ cell development [66], promotes beige adipogenesis, and prevents obesity in middle ‐ aged mice [60].”
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“Maintaining an optimal AKG level for cells contributes to many physiological processes including immune response (Klysz et al. 2015), proliferation and differentiation (Lu and Teitell 2018).”
BackgroundInherent mitochondrial activity influences specification of the germ line in pluripotent stem cells
Bothun, A. M., & Woods, D. C. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03651 · Cited by 7 · see citing works
“Recently, it has been demonstrated that in this ‘primed’ glycolytic state, PGC transient developmental competence can be remarkably extended through the addition of alpha-ketoglutarate (αKG; Lu and Teitell, 2019; Tischler et al., 2019).”
BackgroundMetabolic adaptation pilots the differentiation of human hematopoietic cells
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“Its involvement in epigenetic mechanisms is likely to be the key to its role in stem cell function and cell differentiation (26, 27, 28, 29).”
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Epigenetics, the vascular wall and atherosclerosis
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Regulating Glucose Metabolism Enzymes for Osteoporosis Therapy: Current and Future Approaches
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“Both a -KG and 2-HG can modulate epigenetic modi fi cations through the action of a -KG-dependent dioxygenases (30).”
- Authors
- Lu, V., & Teitell, M. A.
- Affiliations
- University of California, Los Angeles (US)
- California NanoSystems Institute (US)
- Venue
- The EMBO Journal
- Published
- 2018-10-01
- Volume
- 38
- Issue
- 1
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC6315287
- OpenAlex
- W2894293213
- Cited by
- 17
- References
- 13
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (098357/Z/12/Z)
- National Institute of General Medical Sciences (R01GM114188)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F31HD097960)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- alpha-ketoglutarate, TCA cycle, primordial germ cells, germ cell differentiation, naive pluripotency, mouse embryonic stem cells, cellular metabolism
- MeSH terms
- Cell Differentiation, Germ Cells, Ketoglutaric Acids
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