The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants
Open accessAbstract
The transient elevation of cytosolic free calcium concentration ([Ca2+]cyt) induced by cold stress is a well‐established phenomenon; however, the underlying mechanism remains elusive. Here, we report that the Ca2+‐permeable transporter ANNEXIN1 (AtANN1) mediates cold‐triggered Ca2+ influx and freezing tolerance in Arabidopsis thaliana. The loss of function of AtANN1 substantially impaired freezing tolerance, reducing the cold‐induced [Ca2+]cyt increase and upregulation of the cold‐responsive CBF and COR genes. Further analysis showed that the OST1/SnRK2.6 kinase interacted with and phosphorylated AtANN1, which consequently enhanced its Ca2+ transport activity, thereby potentiating Ca2+ signaling. Consistent with these results and freezing sensitivity of ost1 mutants, the cold‐induced [Ca2+]cyt elevation in the ost1‐3 mutant was reduced. Genetic analysis indicated that AtANN1 acts downstream of OST1 in responses to cold stress. Our data thus uncover a cascade linking OST1‐AtANN1 to cold‐induced Ca2+ signal generation, which activates the cold response and consequently enhances freezing tolerance in Arabidopsis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Universal sample preparation method for proteome analysis
Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352
Liu, Q., Kasuga, M., Sakuma, Y., Abe, H., Miura, S., Yamaguchi-Shinozaki, K., & Shinozaki, K. (1998) · The Plant Cell · doi:10.1105/tpc.10.8.1391 · Cited by 3,044
Self-citationStockinger, E. J., Gilmour, S. J., & Thomashow, M. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.1035 · Cited by 1,807
Kim, K.-N., Cheong, Y. H., Grant, J. J., Pandey, G. K., & Luan, S. (2003) · The Plant Cell · doi:10.1105/tpc.006858 · Cited by 406
Structure, function and membrane interactions of plant annexins: An update
Konopka-Postupolska, D., Clark, G., & Hofmann, A. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.05.013 · Cited by 94
Cited by
Protein kinases in plant responses to drought, salt, and cold stress
Chen, X., Ding, Y., Yang, Y., Song, C., Wang, B., Yang, S., Guo, Y., & Gong, Z. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13061 · Cited by 608
Self-citationSurviving and thriving: How plants perceive and respond to temperature stress
Ding, Y., & Yang, S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.03.010 · Cited by 396
Self-citationRegulatory networks in plant responses to drought and cold stress
Kim, J.-S., Kidokoro, S., Yamaguchi-Shinozaki, K., & Shinozaki, K. (2024) · Plant Physiology · doi:10.1093/plphys/kiae105 · Cited by 303
Xie (2021) · doi:10.1111/jipb.13161 · Cited by 180
Metadata
- Authors
- Liu, Q., Ding, Y., Shi, Y., Ma, L., Wang, Y., Song, C., Wilkins, K. A., Davies, J. M., Knight, H., Knight, M. R., Gong, Z., Guo, Y., & Yang, S.
- Venue
- The EMBO Journal
- Published
- 2020-12-29
- Volume
- 40
- Issue
- 2
- Pages
- e104559-e104559
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W3117091332
- Cited by
- 207
- References
- 5
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants. https://app.cochat.ai/papers/10.15252/embj.2020104559
- The paper
- Liu, Q., Ding, Y., Shi, Y., Ma, L., Wang, Y., Song, C., Wilkins, K. A., Davies, J. M., Knight, H., Knight, M. R., Gong, Z., Guo, Y., & Yang, S. (2021). The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants. The EMBO Journal. https://doi.org/10.15252/embj.2020104559
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
