HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,541 · see citing works

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint

Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,877 · see citing works

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works

Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426 · see citing works

Ciliogenesis: building the cell's antenna

Ishikawa, H., & Marshall, W. F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3085 · Cited by 956 · see citing works

HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium

Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890 · see citing works

Roles of Aurora Kinases in Mitosis and Tumorigenesis

Fu, J., Bian, M., Jiang, Q., & Zhang, C. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0208 · Cited by 616 · see citing works

Oncogenic KRAS signalling in pancreatic cancer

Eser, S., Schnieke, A., Schneider, G., & Saur, D. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.215 · Cited by 504 · see citing works

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

Wong, S. Y., Seol, A. D., So, P.-L., Ermilov, A. N., Bichakjian, C. K., Epstein, E. H., Dlugosz, A. A., & Reiter, J. F. (2009) · Nature Medicine · doi:10.1038/nm.2011 · Cited by 463 · see citing works

Hedgehog beyond medulloblastoma and basal cell carcinoma

Teglund, S., & Toftgård, R. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.01.003 · Cited by 426 · see citing works

Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy

Carew, J. S., Giles, F. J., & Nawrocki, S. T. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.037 · Cited by 421 · see citing works

Dual and opposing roles of primary cilia in medulloblastoma development

Han, Y.-G., Kim, H. J., Dlugosz, A. A., Ellison, D. W., Gilbertson, R. J., & Álvarez-Buylla, A. (2009) · Nature Medicine · doi:10.1038/nm.2020 · Cited by 406 · see citing works

Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.

Li, D., Zhu, J., Firozi, P. F., Abbruzzese, J. L., Evans, D. B., Cleary, K. R., Friess, H., & Sen, S. (2003) · PubMed · Cited by 335 · see citing works

Regulating the transition from centriole to basal body

Kobayashi, T., & Dynlacht, B. D. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201101005 · Cited by 324 · see citing works

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

Dovey, O. M., Foster, C. T., & Cowley, S. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000478107 · Cited by 298 · see citing works

Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells

Ji, Z., Mei, F. C., Xie, J., & Cheng, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611089200 · Cited by 296 · see citing works

Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia

Seeley, E. S., Carrière, C., Goetze, T., Longnecker, D. S., & Korc, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1290 · Cited by 283 · see citing works

Cilium assembly and disassembly

Sánchez, I., & Dynlacht, B. D. (2016) · Nature Cell Biology · doi:10.1038/ncb3370 · Cited by 279 · see citing works

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

Bailey, J. M., Mohr, A. M., & Hollingsworth, M. A. (2009) · Oncogene · doi:10.1038/onc.2009.220 · Cited by 275 · see citing works

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

Feldmann, G., Fendrich, V., McGovern, K., Bedja, D., Bisht, S., Alvarez, H., Koorstra, J.-B. M., Habbe, N., Karikari, C. A., Mullendore, M. E., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0573 · Cited by 275 · see citing works

HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth

Gradilone, S. A., Radtke, B. N., Bogert, P. S. T., Huang, B. Q., Gajdos, G. B., & LaRusso, N. F. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2938 · Cited by 225 · see citing works

Centriolar Kinesin Kif24 Interacts with CP110 to Remodel Microtubules and Regulate Ciliogenesis

Kobayashi, T., Tsang, W. Y., Li, J., Lane, W. S., & Dynlacht, B. D. (2011) · Cell · doi:10.1016/j.cell.2011.04.028 · Cited by 220 · see citing works

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

Kim, S., Lee, K., Choi, J.-H., Ringstad, N., & Dynlacht, B. D. (2015) · Nature Communications · doi:10.1038/ncomms9087 · Cited by 173 · see citing works

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA

Fritsche, P., Seidler, B., Schüler, S., Schnieke, A., Göttlicher, M., Schmid, R. M., Saur, D., & Schneider, G. (2009) · Gut · doi:10.1136/gut.2009.180711 · Cited by 167 · see citing works

Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues

Yuan, K., Frolova, N., Xie, Y., Wang, D., Cook, L. M., Kwon, Y.-J., Steg, A. D., Serra, R. A., & Frost, A. R. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955856 · Cited by 162 · see citing works

Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling

Hassounah, N. B., Bunch, T. A., & McDermott, K. M. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0755 · Cited by 156 · see citing works

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation

Miyamoto, T., Hosoba, K., Ochiai, H., Royba, E., Izumi, H., Sakuma, T., Yamamoto, T., Dynlacht, B. D., & Matsuura, S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.003 · Cited by 152 · see citing works

Loss of primary cilia occurs early in breast cancer development

Menzl, I., LeBeau, L. G., Pandey, R., Hassounah, N. B., Li, F. W., Nagle, R. B., Weihs, K. L., & McDermott, K. M. (2014) · Cilia · doi:10.1186/2046-2530-3-7 · Cited by 150 · see citing works

Primary Cilia Are Lost in Preinvasive and Invasive Prostate Cancer

Hassounah, N. B., Nagle, R. B., Saboda, K., Roe, D. J., Dalkin, B. L., & McDermott, K. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068521 · Cited by 139 · see citing works

AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer

Furukawa, T., Kanai, N., Shiwaku, H. O., Soga, N., Uehara, A., & Horii, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209494 · Cited by 135 · see citing works

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells

Lee, K. E., & Bar‐Sagi, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.020 · Cited by 133 · see citing works

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia

Schraml, P., Frew, I. J., Thoma, C. R., Boysen, G., Struckmann, K., Krek, W., & Moch, H. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.132 · Cited by 118 · see citing works

Primary Cilium Depletion Typifies Cutaneous Melanoma In Situ and Malignant Melanoma

Kim, J., Dabiri, S., & Seeley, E. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027410 · Cited by 100 · see citing works

CCRK depletion inhibits glioblastoma cell proliferation in a cilium‐dependent manner

Yang, Y., Roine, N., & Mäkelä, T. P. (2013) · EMBO Reports · doi:10.1038/embor.2013.80 · Cited by 97 · see citing works

Primary cilia and aberrant cell signaling in epithelial ovarian cancer

Egeberg, D. L., Lethan, M., Manguso, R. T., Schneider, L. H., Awan, A., Jørgensen, T. S., Byskov, A. G., Pedersen, L. B., & Christensen, S. T. (2012) · Cilia · doi:10.1186/2046-2530-1-15 · Cited by 93 · see citing works

Oncogenic K-ras Drives Cell Cycle Progression and Phenotypic Conversion of Primary Pancreatic Duct Epithelial Cells

Agbunag, C., & Bar‐Sagi, D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0807 · Cited by 85 · see citing works

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells

Schüler, S., Fritsche, P., Diersch, S., Arlt, A., Schmid, R. M., Saur, D., & Schneider, G. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-80 · Cited by 81 · see citing works

Primary cilia regulate Gli/Hedgehog activation in pancreas

Cervantes, S., Lau, J., Cano, D. A., Borromeo-Austin, C., & Hebrok, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909900107 · Cited by 66 · see citing works

Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines

Nielsen, S., Møllgård, K., Clement, C. A., Veland, I. R., Awan, A., Yoder, B. K., Novak, I., & Christensen, S. T. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21610 · Cited by 64 · see citing works

Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer

Feng, W., Zhang, B., Cai, D., & Zou, X. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.02.012 · Cited by 64 · see citing works

Lovastatin Inhibits Pancreatic Cancer Growth Regardless of RAS Mutation

Sumi, S., Beauchamp, R. D., Townsend, C. M., Pour, S. M., Ishizuka, J., & Thompson, J. (1994) · Pancreas · doi:10.1097/00006676-199409000-00018 · Cited by 60 · see citing works

Cilia and cilia-associated proteins in cancer

Seeger‐Nukpezah, T., Little, J. L., Serzhanova, V., & Golemis, E. A. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.03.004 · Cited by 54 · see citing works

Absence of primary cilia in cell cycle‐arrested human breast cancer cells

Nobutani, K., Shimono, Y., Yoshida, M., Mizutani, K., Minami, A., Kono, S., Mukohara, T., Yamasaki, T., Itoh, T., Takao, S., et al. (2013) · Genes to Cells · doi:10.1111/gtc.12122 · Cited by 46 · see citing works

Pancreatic Duct Epithelial Cell Isolation and Cultivation in Two‐Dimensional and Three‐Dimensional Culture Systems

Agbunag, C., Lee, K. E., Buontempo, S., & Bar‐Sagi, D. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07055-2 · Cited by 44 · see citing works

A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells

Ischenko, I., Petrenko, O., & Hayman, M. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4538 · Cited by 42 · see citing works

Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet–Biedl syndrome

Kobayashi, T., Hori, Y., Ueda, N., Kajiho, H., Muraoka, S., Shima, F., Kataoka, T., Kontani, K., & Katada, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.087 · Cited by 24 · see citing works

The regulation of cilium assembly and disassembly in development and disease

Wang, L., & Dynlacht, B. D. (2018) · Development · doi:10.1242/dev.151407 · Cited by 194 · see citing works

Ciliary signalling in cancer

Liu, H., Kiseleva, A. A., & Golemis, E. A. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0023-6 · Cited by 173 · see citing works

Primary cilia biogenesis and associated retinal ciliopathies

Chen, H. Y., Kelley, R. A., Li, T., & Swaroop, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.07.013 · Cited by 106 · see citing works

Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer

Fukumoto, T., Park, P. H., Wu, S., Fatkhutdinov, N., Karakashev, S. V., Nacarelli, T., Kossenkov, A. V., Speicher, D. W., Jean, S., Zhang, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.019 · Cited by 104 · see citing works

Mixed signals from the cell's antennae: primary cilia in cancer

Eguether, T., & Hahne, M. (2018) · EMBO Reports · doi:10.15252/embr.201846589 · Cited by 100 · see citing works

Primary cilia proteins: ciliary and extraciliary sites and functions

Hua, K., & Ferland, R. J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2740-5 · Cited by 91 · see citing works

Primary ciliary signaling: links with the cell cycle

Kasahara, K., & Inagaki, M. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.07.009 · Cited by 81 · see citing works

Histone deacetylase 2 selective inhibitors: A versatile therapeutic strategy as next generation drug target in cancer therapy

Shetty, M. G., Pai, P., Deaver, R. E., Satyamoorthy, K., & Babitha, K. S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105695 · Cited by 73 · see citing works

The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods

Curcio, A., Rocca, R., Alcaro, S., & Artese, A. (2024) · Pharmaceuticals · doi:10.3390/ph17050620 · Cited by 71 · see citing works

Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

Pant, K., Peixoto, E., Richard, S., & Gradilone, S. A. (2020) · Cells · doi:10.3390/cells9030780 · Cited by 68 · see citing works

Cilia interactome with predicted protein-protein interactions reveals connections to Alzheimer’s disease, aging and other neuropsychiatric processes

Karunakaran, K. B., Chaparala, S., Lo, C. W., & Ganapathiraju, M. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-72024-4 · Cited by 56 · see citing works

HDACs and the epigenetic plasticity of cancer cells: target the complexity

Brancolini, C., Gagliano, T., & Minisini, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108190 · Cited by 55 · see citing works

Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma

Kuonen, F., Huskey, N. E., Shankar, G., Jaju, P. D., Whitson, R. J., Rieger, K. E., Atwood, S. X., Sarin, K. Y., & Oro, A. E. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.11.035 · Cited by 49 · see citing works

HDAC2 Facilitates Pancreatic Cancer Metastasis

Krauß, L., Urban, B. C., Hastreiter, S., Schneider, C., Wenzel, P., Hassan, Z., Wirth, M., Lankes, K., Terrasi, A., Klement, C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3209 · Cited by 49 · see citing works

Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer

Gomes-Filho, S. M., dos Santos, E. O., Bertoldi, E. R. M., Scalabrini, L. C., Heidrich, V., Dazzani, B., Levantini, E., Reis, E. M. R., & Bassères, D. S. D. S. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00498-5 · Cited by 43 · see citing works

Functional aspects of primary cilium in signaling, assembly and microenvironment in cancer

Wang, B., Liang, Z., & Liu, P. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30117 · Cited by 45 · see citing works

The primary cilium: Its role as a tumor suppressor organelle

Peixoto, E., Richard, S., Pant, K., Biswas, A. S., & Gradilone, S. A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113906 · Cited by 41 · see citing works

Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer

Pramanik, S. D., Halder, A. K., Mukherjee, U., Kumar, D., Dey, Y. N., & Mogana, R. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.948217 · Cited by 40 · see citing works

Histone Deacetylase 2 Is a Component of Influenza A Virus-Induced Host Antiviral Response

Nagesh, P. T., Hussain, M., Galvin, H. D., & Husain, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01315 · Cited by 37 · see citing works

TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation

Qie, Y., Wang, L., Du, E., Chen, S., Lü, C., Ding, N., Yang, K., & Xu, Y. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111952 · Cited by 37 · see citing works

Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., et al. (2019) · Cancers · doi:10.3390/cancers11091327 · Cited by 34 · see citing works

Insights into the Regulation of Ciliary Disassembly

Patel, M. M., & Tsiokas, L. (2021) · Cells · doi:10.3390/cells10112977 · Cited by 34 · see citing works

RABL2 positively controls localization of GPCRs in mammalian primary cilia

Dateyama, I., Sugihara, Y., Chiba, S., Ota, R., Nakagawa, R., Kobayashi, T., & Itoh, H. (2018) · Journal of Cell Science · doi:10.1242/jcs.224428 · Cited by 30 · see citing works

Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation

Senatore, E., Iannucci, R., Chiuso, F., Donne, R. D., Rinaldi, L., & Feliciello, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.833086 · Cited by 28 · see citing works

Prdx1 promotes the loss of primary cilia in esophageal squamous cell carcinoma

Chen, Q., Li, J., Yang, X., Ma, J., Gong, F., & Liu, Y. (2020) · BMC Cancer · doi:10.1186/s12885-020-06898-y · Cited by 24 · see citing works

Histone deacetylases: A novel class of therapeutic targets for pancreatic cancer

Xiang, X.-S., Li, P., Wang, W., & Liu, L. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188676 · Cited by 23 · see citing works

Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland.

Lee, J., Yi, S., Chang, J. Y., Kim, J. T., Sul, H. J., Park, K. C., Zhu, X., Cheng, S.-Y., Kero, J. T., Kim, J., et al. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0430 · Cited by 24 · see citing works

Recent advances in the understanding of cilia mechanisms and their applications as therapeutic targets

Saito, M., Otsu, W., Miyadera, K., & Nishimura, Y. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1232188 · Cited by 21 · see citing works

Primary cilia: Structure, dynamics, and roles in cancer cells and tumor microenvironment

Guan, Y., Zhang, C., Zhang, H., Wei, W., Yue, W., Zhao, W., & Zhang, D. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31092 · Cited by 20 · see citing works

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

Shiromizu, T., Yuge, M., Kasahara, K., Yamakawa, D., Matsui, T., Bessho, Y., Inagaki, M., & Nishimura, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175962 · Cited by 18 · see citing works

Aurora A and AKT Kinase Signaling Associated with Primary Cilia

Nishimura, Y., Yamakawa, D., Shiromizu, T., & Inagaki, M. (2021) · Cells · doi:10.3390/cells10123602 · Cited by 17 · see citing works

Cilia and Cancer: From Molecular Genetics to Therapeutic Strategies

Carotenuto, P., Gradilone, S. A., & Franco, B. (2023) · Genes · doi:10.3390/genes14071428 · Cited by 19 · see citing works

Activation of EGFR‐Aurora A induces loss of primary cilia in oral squamous cell carcinoma

Yin, F., Chen, Q., Shi, Y., Xu, H. Y., Huang, J., Qing, M., Liang, Z., Li, J., Xie, L., & Zeng, X. Y. (2021) · Oral Diseases · doi:10.1111/odi.13791 · Cited by 17 · see citing works

Patterns of Ciliation and Ciliary Signaling in Cancer

Kiseleva, A. A., Nikonova, A. S., & Golemis, E. A. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_36 · Cited by 17 · see citing works

Carnitine Protects against MPP+-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells

Bae, J.-E., Kim, J. B., Jo, D. S., Park, N. Y., Kim, Y. H., Lee, H. J., Kim, S. H., Ys, K., Son, M., Kim, P., et al. (2022) · Cells · doi:10.3390/cells11172722 · Cited by 16 · see citing works

Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway

Inoue, M., Baba, T., Takahashi, F., Terao, M., Yanai, S., Shima, Y., Saito, D., Sugihara, K., Miura, T., Takada, S., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03941-5 · Cited by 16 · see citing works

Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse

Bangs, F. K., Miller, P. F., & O’Neill, E. E. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.044289 · Cited by 16 · see citing works

Freeing the brake: Proliferation needs primary cilium to disassemble

Halder, P., Khatun, S., & Majumder, S. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00090-x · Cited by 15 · see citing works

Primary cilia: a novel research approach to overcome anticancer drug resistance

Lee, K. H. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1270639 · Cited by 13 · see citing works

CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells

Kobayashi, T., Tanaka, K., Mashima, Y., Shoda, A., Tokuda, M., & Itoh, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.587691 · Cited by 13 · see citing works

Loss of a primary cilium in PDAC

Kobayashi, T., & Itoh, H. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1304738 · Cited by 11 · see citing works

Cilia at the crossroad: convergence of regulatory mechanisms to govern cilia dynamics during cell signaling and the cell cycle

Čajánek, L., Smite, S., Ivashchenko, O., & Huranová, M. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01403-z · Cited by 10 · see citing works

KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells

Mashima, Y., Nohira, H., Sugihara, H., Dynlacht, B. D., Kobayashi, T., & Itoh, H. (2022) · Life Science Alliance · doi:10.26508/lsa.202201470 · Cited by 10 · see citing works

Molecular targets of primary cilia defects in cancer (Review)

Yin, F., Wei, Z., Chen, F., Xin, C., & Chen, Q. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5388 · Cited by 8 · see citing works

PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity

Fiedler, J., Moennig, T., Hinrichs, J. H., Weber, A., Wagner, T., Hemmer, T., Schröter, R., Weide, T., Epting, D., Bergmann, C., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04994-3 · Cited by 8 · see citing works

Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna

Rocha, C., & Prinos, P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.809917 · Cited by 8 · see citing works

HDAC3 and HDAC8 are required for cilia assembly and elongation

Park, S.-A., Yoo, H., Seol, J. H., & Rhee, K. (2019) · Biology Open · doi:10.1242/bio.043828 · Cited by 8 · see citing works

Cilia Action in Islets: Lessons From Mouse Models

Jung, H.-C., & Hughes, J. W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.922983 · Cited by 6 · see citing works

N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression

Rui, Y., Zhang, H., Yu, K., Qiao, S., Gao, C., Wang, X., Yang, W., Asadikaram, G., Li, Z., Zhang, K., et al. (2024) · Advanced Science · doi:10.1002/advs.202408488 · Cited by 5 · see citing works

The atypical small GTPase RABL3 interacts with RAB11 to regulate early ciliogenesis in human cells

Kobayashi, T., Ikeda, T., Ota, R., Yasukawa, T., & Itoh, H. (2022) · Journal of Cell Science · doi:10.1242/jcs.260021 · Cited by 6 · see citing works

Gene Network Analysis of Hepatocellular Carcinoma Identifies Modules Associated with Disease Progression, Survival, and Chemo Drug Resistance

Ye, H., Sun, M., Huang, S., Xu, F., Wang, J., Liu, H., Zhang, L., Luo, W., Guo, W., Wu, Z., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s336729 · Cited by 5 · see citing works

Abnormal accumulation of OFD1 in endometrial cancer with poor prognosis inhibits ciliogenesis

Kojima, R., Hassan, E., Ozawa, F., Yamada‐Namikawa, C., Ogawa, S., Mase, S., Goto, S., Nishikawa, R., Inagaki, H., Kato, Y., et al. (2022) · Oncology Letters · doi:10.3892/ol.2022.13334 · Cited by 4 · see citing works

Primary Cilia: Hub of Cell Signal Transduction and Emerging Role in Digestive System Tumorigenesis

Song, W., Wang, M., Kong, S., Liu, Y., Yan, X., Bai, H., & Wang, Y. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70102 · Cited by 3 · see citing works

CEP164-GLI2 association ensures the hedgehog signaling in pancreatic cancer cells

Fushimi, T., Kobayashi, T., & Itoh, H. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.05.031 · Cited by 3 · see citing works

Inpp5e Regulated the Cilium-Related Genes Contributing to the Neural Tube Defects Under 5-Fluorouracil Exposure

Wang, X., Yu, J., Yue, H., Li, S., Yang, A., Zhu, Z., Guan, Z., & Wang, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03946-7 · Cited by 3 · see citing works

Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner

Tian, J., Mallinger, J. C., Shi, P., Ling, D., Deleyrolle, L. P., Lin, M., Khoshbouei, H., & Sarkisian, M. R. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.101956 · Cited by 3 · see citing works

Primary cilia in the hypothalamic AgRP neurons mediate metabolic effects of butyrate

Rijal, S., Yang, D. J., Doan, K. V., Lyoo, S. H., Lee, A., Choi, Y.-H., Shin, D. M., & Kim, K. W. (2026) · Nature Communications · doi:10.1038/s41467-026-71745-w · Cited by 2 · see citing works

A type of pancreatic cancer cells form cell clusters from a solitary condition in a primary ciliogenesis-dependent manner

SHIRAKAWA, K., Nakazato, R., Hara, T., Uemura, K., Ijaz, F., Takahashi, S., & Ikegami, K. (2025) · Medical Molecular Morphology · doi:10.1007/s00795-025-00428-0 · Cited by 2 · see citing works

Bulk anda single-cell transcriptome profiling reveals the molecular characteristics of T cell-mediated tumor killing in pancreatic cancer

Dai, Y., Pan, Y.-T., Lin, D., Chen, X., Zhou, X., & Wang, W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27216 · Cited by 1 · see citing works

Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia

Jun, J. H., Cha, H., Ko, J. Y., Kim, H., Yoo, K. H., & Park, J. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-86292-5 · Cited by 1 · see citing works

RalGAP complexes control secretion and primary cilia in pancreatic disease

Apken, L. H., Barz, H., Beel, S., Michalke, E., Rasche, R., Verma, A., Ricker, A., Nüsse, H., Klingauf, J., Kerl, K., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202403123 · Cited by 1 · see citing works

Targeting the ubiquitin system for treatment of cilia-related diseases

Nishimura, Y., & Inagaki, M. (2020) · Folia Pharmacologica Japonica · doi:10.1254/fpj.20072

KIF24 controls the clustering of supernumerary centrosomes in pancreatic ductal adenocarcinoma cellsPreprint

Mashima, Y., Nohira, H., Sugihara, H., Dynlacht, B. D., Kobayashi, T., & Itoh, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.16.484562

Differential transcriptome analysis of Dunaliella salina during flagellar assemblyPreprint

Zhu, L., Hu, L., Li, A., Li, S., Li, Y., Wang, Q., Huang, Y., Feng, Y., Li, Q., & Feng, S. (2022) · Research Square · doi:10.21203/rs.3.rs-2222140/v1

Loss of Bbs8 leads to cystic kidney disease in mice with reduced acetylation of ciliary alpha-tubulin through HDAC2Preprint

Kieckhöfer, E., Günzler, J., Matthiessen, P. A., Ebert, L. K., Klausen, C., Wachten, D., Cetiner, M., Liebau, M. C., Benzing, T. R., May‐Simera, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.07.583949

Breaking down glioma primary cilia disassembly

Sarkisian, M. R., Deleyrolle, L. P., & Breunig, J. J. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf217

Unfolding the role of HDAC2 in the epigenetic puzzle of cancer: A dive into molecular pathways for precision-driven multi-target therapy

Sarkar, K., Debbarma, M., Debnath, S., Debnath, S., & Sil, S. K. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117534

Enhanced release of ciliary extracellular vesicles suppresses cell migration and promotes cell aggregation

Hara, T., Nakazato, R., SHIRAKAWA, K., Ijaz, F., Uemura, K., Takahashi, S., & Ikegami, K. (2026) · Cell Structure and Function · doi:10.1247/csf.25152

Primary cilia on colonic mesenchymal cells regulate DSS-induced colitis and inflammation associated colon carcinogenesis

Tang, R. (2017) · doi:10.70675/95f7149azf332z4c88za467z1c09b6b68a45

Ciblage thérapeutique de la réponse au stress cellulaire dans l'ostéosarcome

Moukengué, B. (2019) · theses.fr (ABES) · doi:10.70675/26cb2736z4fbdz42d2zabcbzca5db0a782e1

Étude de la tumorigenèse pancréatique des tumeurs intracanalaires papillaires et mucineuses du pancréas (TIPMP)

Lorenzo, D. (2024) · doi:10.70675/ba1107b2ze1c9z4e6ezad24z3a1778a18d7e

A novel mutation of IFT140 in a preschool child with Mainzer-Saldino syndrome accompanied by rare tumor blastic plasmacytoid dendritic cell neoplasm: a case report

Hu, R., Li, J., Yang, F., & Jiang, M. (2026) · BMC Pediatrics · doi:10.1186/s12887-026-06868-6

Primary cilium disassembly – from mechanisms to roles in physiology and disease

Ott, C. M., Lippincott‐Schwartz, J., & Breslow, D. K. (2026) · Journal of Cell Science · doi:10.1242/jcs.264820

Primary cilium as a sensory organelle and metabolic hub in health and diseases

Hou, H.-T., Chao, Y., Li, J., Peng, I., Lin, T., Wen-Tai, C., Wang, C., & Tsai, S.-J. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01291-6

Role of primary cilium in pancreatic ductal adenocarcinoma (Review)

Šabanović, B., Giulietti, M., & Piva, F. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5121 · Cited by 4 · see citing works

A type of pancreatic cancer cells form cell clusters from a solitary condition in a primary ciliogenesis-dependent manner

SHIRAKAWA, K., Nakazato, R., Hara, T., Uemura, K., Ijaz, F., Takahashi, S., & Ikegami, K. (2025) · Medical Molecular Morphology · doi:10.1007/s00795-025-00428-0 · Cited by 2 · see citing works

CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells

Kobayashi, T., Tanaka, K., Mashima, Y., Shoda, A., Tokuda, M., & Itoh, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.587691 · Cited by 13 · see citing works

Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia

Seeley, E. S., Carrière, C., Goetze, T., Longnecker, D. S., & Korc, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1290 · Cited by 283 · see citing works

HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth

Gradilone, S. A., Radtke, B. N., Bogert, P. S. T., Huang, B. Q., Gajdos, G. B., & LaRusso, N. F. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2938 · Cited by 225 · see citing works