The integrated stress response

Cites (276)

Items 201–276 of 276

1. Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition
   Jinsong Hu, Nana Dang, Eline Menu, Elke De Bryune, Dehui Xu, Ben Van Camp, Els Van Valckenborgh, Karin Vanderkerken · 2011 · Blood
2. p300 Modulates ATF4 Stability and Transcriptional Activity Independently of Its Acetyltransferase Domain
   Irina Lassot, Emilie Estrabaud, Stéphane Emiliani, Monsef Benkirane, Richard Bénarous, Florence Margottin-Goguet · 2005 · Journal of Biological Chemistry
3. Computational Analysis of Dynamical Responses to the Intrinsic Pathway of Programmed Cell Death
   Tongli Zhang, Paul Brazhnik, John J. Tyson · 2009 · Biophysical Journal
4. p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear
   Wei, Wei, Coelho, Carlos M., Li, Xiang, Marek, Roger, Yan, Shanzhi, Anderson, Shawn, Meyers, David, Mukherjee, Chandrani, Sbardella, Gianluca, Castellano, Sabrina et al. · 2012 · The Journal of Neuroscience
5. Crystal Structure of the CCAAT Box/Enhancer-binding Protein β Activating Transcription Factor-4 Basic Leucine Zipper Heterodimer in the Absence of DNA
   Larissa M. Podust, Andrzej M. Krezel, Youngchang Kim · 2001 · Journal of Biological Chemistry
6. Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis*
   Christopher L. Frank, Xuecai Ge, Zhigang Xie, Ying Zhou, Li‐Huei Tsai · 2010 · Journal of Biological Chemistry
7. Characterization of the Hemin-sensitive Eukaryotic Initiation Factor 2α Kinase from Mouse Nonerythroid Cells
   Juan José Berlanga, Saturnino Herrero, César de Haro · 1998 · Journal of Biological Chemistry
8. Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation
   María Salazar‐Roa, Mar Lorente, Elena García-Taboada, Eduardo Pérez-Gómez, David Dávila, Patricia Zúñiga-García, J.M. Flores, A Rodríguez, Zoltán Hegedüs, David Mosén-Ansorena et al. · 2014 · Cell Death and Differentiation
9. Salermide up‐regulates death receptor 5 expression through the ATF4‐ATF3‐CHOP axis and leads to apoptosis in human cancer cells
   Guangbo Liu, Ling Su, Xuexi Hao, Ning Zhong, Diansheng Zhong, Sunil Kumar Singhal, Xiangguo Liu · 2011 · Journal of Cellular and Molecular Medicine
10. GADD34 induces cell death through inactivation of Akt following traumatic brain injury
    J. M. Farook, J. Shields, Amany Tawfik, S. Markand, Tanusree Sen, Sylvia B. Smith, D. Brann, K. Dhandapani, Nilkantha Sen · 2013 · Cell Death and Disease
11. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
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12. A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway
    Shirin Kazemi, Zineb Mounir, Dionissios Baltzis, Jennifer F. Raven, Shuo Wang, Jothilatha Krishnamoorthy, Olivier Pluquet, Jerry Pelletier, Antonis E. Koromilas · 2007 · Molecular Biology of the Cell
13. Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
    Tewfik Hamidi, Carla Eliana Cano, Daniel Grasso, María Noé Garcia, María José Sandí, Ezequiel Luis Calvo, Jean–Charles Dagorn, Gwen Alyce Lomberk, Raul A. Urrutia, Sandro Goruppi et al. · 2012 · Clinical Cancer Research
14. Mouse NIPK interacts with ATF4 and affects its transcriptional activity
    Daima Örd, Tõnis Örd · 2003 · Experimental Cell Research
15. The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Inhibits the Replication of Vaccinia Virus
    Sean Bong Lee, Mariano Estéban · 1993 · Virology
16. Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival
    Svetlana Saveljeva, Patricia Cleary, Katarzyna Mnich, Abiodun Ayo, Karolina Pakos‐Zebrucka, John B. Patterson, Susan E. Logue, Afshin Samali · 2016 · Oncotarget
17. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation
    Joseph E. Chambers, Lucy E. Dalton, Hanna J. Clarke, Elke Malzer, Caia S. Dominicus, Vruti Patel, Greg B. G. Moorhead, David Ron, Stefan John Marciniak · 2015 · eLife
18. G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases
    Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J. Clarke, Heather P. Harding, Stefan John Marciniak, Randy J. Read, David Ron · 2015 · eLife
19. Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase
    Azmi Yerlikaya, Scot R. Kimball, Bruce A. Stanley · 2008 · Biochemical Journal
20. Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4)
    Thipparthi Raghavendar Reddy, Hengli Tang, Xinqiang Li, Flossie Wong‐Staal · 1997 · Oncogene
21. ATF4 promotes bone angiogenesis by increasing vegf expression and release in the bone environment
    Ke Zhu, Hongli Jiao, Shuai Li, Huiling Cao, Deborah Lynn Galson, Zhongfang Zhao, Xi Zhao, Yumei Lai, Jie Fan, Hee‐Jeong Im et al. · 2013 · Journal of Bone and Mineral Research
22. Heme‐regulated eIF‐2α kinase purifies as a hemoprotein
    Peter J. Chefalo, Jihyun Oh, Maryam Rafie‐Kolpin, Beki Kan, Jane-Jane Chen · 1998 · European Journal of Biochemistry
23. Defects in Translational Regulation Mediated by the α Subunit of Eukaryotic Initiation Factor 2 Inhibit Antiviral Activity and Facilitate the Malignant Transformation of Human Fibroblasts
    Darren J. Perkins, Glen N. Barber · 2004 · Molecular and Cellular Biology
24. Mechanism of activation of the double‐stranded‐RNA‐dependent protein kinase, PKR
    Krishna M. Vattem, Kirk A. Staschke, Ronald C. Wek · 2001 · European Journal of Biochemistry
25. Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease
    François Mouton‐Liger, Claire Paquet, Julien Dumurgier, Pauline Lapalus, Françoise Gray, Jean Laplanche, Jacques Hugon · 2012 · Biological Psychiatry
26. PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells
    Claire E. Moore, Omotola Omikorede, Edith Gomez, Gary B. Willars, Terence P. Herbert · 2010 · Molecular Endocrinology
27. Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction
    Hui-Ren Zhou, Kaiyu He, Jeff Landgraf, Xiao Pan, James J. Pestka · 2014 · Toxins
28. Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease
    Latha Devi, Masuo Ohno · 2013 · PLoS ONE
29. A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis
    Kamil Erguler, Myrtani Pieri, Constantinos C. Deltas · 2013 · BMC Systems Biology
30. Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
    Melissa R. Hogan, Gregory P. Cockram, Rui Lu · 2005 · FEBS Letters
31. Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response
    Sara K. Young-Baird, Lakshmi Reddy Palam, Cheng Wu, Matthew S. Sachs, Ronald C. Wek · 2016 · Journal of Biological Chemistry
32. Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress
    Masamitsu Shimazawa, Hideaki Hara · 2006 · Neuroscience Letters
33. A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy
    Shane Deegan, Izabela Koryga, Sharon Anneve Glynn, Sanjeev Gupta, Adrienne M. Gorman, Afshin Samali · 2014 · Biochemical and Biophysical Research Communications
34. An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response
    Aude De Gassart, Bojan Bujisic, Léa Zaffalon, Laurent Arthur Decosterd, Antonia Di Micco, Gianluca Frera, Rémy Tallant, Fabio Martinon · 2015 · Proceedings of the National Academy of Sciences
35. Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response
    Ching-Ping Chan, Kin‐Hang Kok, Hei-Man Vincent Tang · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
36. Multicopy tRNA Genes Functionally Suppress Mutations in Yeast eIF-2α Kinase GCN2: Evidence for Separate Pathways Coupling GCN4 Expression to Uncharged tRNA
    Carlos R. Vázquez de Aldana, Ronald C. Wek, Pedro A. San-Segundo, Alexander G. Truesdell, Alan G. Hinnebusch · 1994 · Molecular and Cellular Biology
37. Autophosphorylation of Threonine 485 in the Activation Loop Is Essential for Attaining eIF2α Kinase Activity of HRI
    Maryam Rafie‐Kolpin, Anping Han, Jane-Jane Chen · 2003 · Biochemistry
38. Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention
    Pavel A. Tsaytler, Anne Bertolotti · 2012 · FEBS Journal
39. cDNA clones encoding leucine‐zipper proteins which interact with G‐CSF gene promoter element 1‐binding protein
    Mikio Nishizawa, Shigekazu Nagata · 1992 · FEBS Letters
40. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation
    Huarong Chen, Renduo Song, Guohui Wang, Zonghui Ding, Chunying Yang, Jiawei Zhang, Zihua Zeng, Valentina Rubio, Luchang Wang, Nancy Zu et al. · 2015 · Scientific Reports
41. Oxidative stress induces PKR-dependent apoptosis via IFN-γ activation signaling in Jurkat T cells
    Chul-Woong Pyo, Shin-Hee Lee, Sang-Yun Choi · 2008 · Biochemical and Biophysical Research Communications
42. Transcriptional Repression of ATF4 Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress Response
    Souvik Dey, Sudha S. Savant, Brian F. Teske, Maria Hatzoglou, Cornelis F. Calkhoven, Ronald C. Wek · 2012 · Journal of Biological Chemistry
43. Double-stranded RNA-dependent Protein Kinase (pkr) Is Essential for Thermotolerance, Accumulation of HSP70, and Stabilization of ARE-containing HSP70 mRNA during Stress
    Meijuan Zhao, Dan Tang, Stanislav Lechpammer · 2002 · Journal of Biological Chemistry
44. ATF 4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells
    Clara Lucía León‐Annicchiarico, Silvia Ramírez‐Peinado, Dídac Domínguez‐Villanueva, Anika Gonsberg, Théodore J. Lampidis, Cristina Muñoz‐Pinedo · 2015 · FEBS Journal
45. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells
    Linyan Xu, Ling Su, Xiangguo Liu · 2012 · Molecular Cancer Therapeutics
46. Lipopolysaccharide Induces Autophagic Cell Death through the PERK-Dependent Branch of the Unfolded Protein Response in Human Alveolar Epithelial A549 Cells
    Shaoying Li, Liang Guo, Pin Qian, Yunfeng Zhao, Ao Liu, Fuyun Ji, Liutong Chen, Xueling Wu, Guisheng Qian · 2015 · Cellular Physiology and Biochemistry
47. Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4
    Hyeon‐Ok Jin, Sung‐Keum Seo, Sang‐Hyeok Woo, Taeboo Choe, Seok‐Il Hong, Jong‐Il Kim, In‐Chul Park · 2009 · IUBMB Life
48. p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity
    Roobol, Anne, Roobol, Jo, Bastide, Amandine, Knight, John R. P., Willis, Anne E., Smales, C. Mark · 2015 · Biochemical Journal
49. Ribosome Association of GCN2 Protein Kinase, a Translational Activator of the GCN4 Gene of Saccharomyces cerevisiae
    Manuel Ramirez, Ronald C. Wek, Alan G. Hinnebusch · 1991 · Molecular and Cellular Biology
50. Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury
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51. The Role of Nitric-oxide Synthase in the Regulation of UVB Light-induced Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2
    Wei Lu, Csaba László, Zhixin Miao, Hao Chen, Shiyong Wu · 2009 · Journal of Biological Chemistry
52. Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses
    Patricija van Oosten‐Hawle, Richard I. Morimoto · 2013 · Journal of Experimental Biology
53. Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor‐4 (ATF4)
    Roberta De Angelis, Simona Iezzi, Tiziana Bruno, Nicoletta Corbi, Monica Di Padova, Aristide Floridi, Maurizio Fanciulli, Claudio Passananti · 2003 · FEBS Letters
54. Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.
    Emmanuel Ampofo, T. Sokolowsky, C. Götz, M. Montenarh · 2013 · Biochimica et Biophysica Acta
55. Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2
    Marzia Scortegagna, Hyungsoo Kim, Jian‐Liang Li, Hang Yao, Laurence M. Brill, Jaeseok Han, Eric K. Lau, David D.L. Bowtell, Gabriel Haddad, Randal J. Kaufman et al. · 2014 · PLoS Genetics
56. Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2α (HRI) kinase
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57. Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes
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58. Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress
    Yu Wang, Shengqiang Xu, Xiaoxian Zhang · 2011 · The Journal of Pathology
59. Blocking UV‐Induced eIF2α Phosphorylation with Small Molecule Inhibitors of GCN2
    Francis Robert, Chris Williams, Yifei Yan, Elizabeth Donohue, Regina Cencic, Stephen Kevin Burley, Jerry Pelletier · 2009 · Chemical Biology & Drug Design
60. Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress
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61. DNA Damage Regulates Translation through β-TRCP Targeting of CReP
    Theresa B. Loveless, Benjamin R. Topacio, Ajay Amar Vashisht, Shastyn Galaang, Katie Ulrich, Brian D. Young, James Akira Wohlschlegel, David Paul Toczyski · 2015 · PLoS Genetics
62. Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis
    Gerard ILL‐Raga, Marta Tajes, Arnau Busquets-García, Eva Ramos‐Fernández, Lina M. Vargas, Mònica Bosch-Morató, Biuse Guivernau, Victòria Valls-Comamala, Abel Eraso‐Pichot, Francesc Xavier Guix et al. · 2015 · Antioxidants and Redox Signaling
63. Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4
    Xubin Zhou, Rong Wang, Libin Fan, Yan Li, Li Ma, Zhenye Yang, Wei Yu, Naihe Jing, Xueliang Zhu · 2005 · Journal of Biological Chemistry
64. Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma
    Stacey L. Lehman, Sandra W. Ryeom, Constantinos Koumenis · 2015 · Scientific Reports
65. Endoplasmic reticulum stress-mediated autophagy contributes to bluetongue virus infection via the PERK-eIF2α pathway
    Shuang Lv, Encheng Sun, Qingyuan Xu, Jikai Zhang, Donglai Wu · 2015 · Biochemical and Biophysical Research Communications
66. PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation
    Yusuke Hiwatashi, Kohei Kanno, Chikahisa Takasaki, Kenji Goryo, Takuya Sato, Satoru Torii, Kazuhiro Sogawa, Ken‐ichi Yasumoto · 2011 · Experimental Cell Research
67. The GABAB receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development
    Barbara Ritter, Jana Zschüntzsch, Elena Kvachnina, Weiqi Zhang, Evgeni G. Ponimaskin · 2004 · Developmental Brain Research
68. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells
    Kevin F. Bryant, Elizabeth R. Macari, Natasha Malik · 2008 · Virology
69. Double-Stranded RNA-Dependent Protein Kinase-Dependent Apoptosis Induction by a Novel Small Compound
    Wenxian Hu, Wayne Lewis Hofstetter, Xiaoli Wei, Wei Guo, Yanbin Zhou, Abujiang Pataer, Hong Li, Bingliang Fang, Stephen G. Swisher · 2008 · Journal of Pharmacology and Experimental Therapeutics
70. Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response
    Ann Collier, Ronald C. Wek, Dan F. Spandau · 2015 · Journal of Investigative Dermatology
71. Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK
    Bart R. Anderson, Katalin Karikó, Drew Weissman · 2012 · Gene Therapy
72. ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway
    Camilla T. Ambivero, Lucia Cilenti, Antonis S. Zervos · 2012 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
73. Phosphorylation-dependent structure of ATF4 peptides derived from a human ATF4 protein, a member of the family of transcription factors
    Julien Pons, Nathalie Evrard‐Todeschi, Gildas Bertho, Josyane Gharbi‐Benarous, Richard Bénarous, Jean‐Pierre Girault · 2007 · Peptides
74. GADD34 Facilitates Cell Death Resulting from Proteasome Inhibition.
    Lintao Liu, Sachiko Ito, Naomi Nishio · 2015 · PubMed
75. Identification of Cys385 in the isolated kinase insertion domain of heme-regulated eIF2α kinase (HRI) as the heme axial ligand by site-directed mutagenesis and spectral characterization
    Kyoko Hirai, Markéta Martínková, Jotaro Igarashi · 2007 · Journal of Inorganic Biochemistry
76. FIAT, the factor‐inhibiting ATF4‐mediated transcription, also represses the transcriptional activity of the bZIP factor FRA‐1
    René St‐Arnaud, Vice Mandic, Bilal Elchaarani · 2010 · Annals of the New York Academy of Sciences