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QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity

Lu, Huanyu, Ye, Zichen, Zhai, Yue, Wang, Li, Liu, Ying, Wang, Jiye, Zhang, Wenbin, Luo, Wenjing, Lu, Zifan, Chen, Jingyuan·2020·The EMBO Reports
DOI 10.15252/embr.201947929
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Research works printed but not linked: 51

  1. NCD Risk Factor Collaboration (NCD‐RisC) (2017) Worldwide trends in body‐mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population‐based measurement studies in 128.9 million children, adolescents, and adults. Lancet 390: 2627–2642 · DOI · Paper page
  2. Giralt M, Villarroya F (2013) White, brown, beige/brite: different adipose cells for different functions? Endocrinology 154: 2992–3000 · DOI
  3. Saely CH, Geiger K, Drexel H (2012) Brown versus white adipose tissue: a mini‐review. Gerontology 58: 15–23 · DOI
  4. Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, Buchholz BA, Eriksson M, Arner E, Hauner H et al (2011) Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478: 110–113 · DOI
  5. Srivastava A, Shankar K, Beg M, Rajan S, Gupta A, Varshney S, Kumar D, Gupta S, Mishra RK, Gaikwad AN (2018) Chronic hyperinsulinemia induced miR‐27b is linked to adipocyte insulin resistance by targeting insulin receptor. J Mol Med 96: 315–331 · DOI
  6. Shabalina IG, Petrovic N, de Jong JM, Kalinovich AV, Cannon B, Nedergaard J (2013) UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep 5: 1196–1203 · DOI
  7. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts‐Toler C, Weiner LS, Sze C et al (2013) Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 19: 635–639 · DOI
  8. Lidell ME, Betz MJ, Dahlqvist Leinhard O, Heglind M, Elander L, Slawik M, Mussack T, Nilsson D, Romu T, Nuutila P et al (2013) Evidence for two types of brown adipose tissue in humans. Nat Med 19: 631–634 · DOI
  9. Nedergaard J, Cannon B (2010) The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 11: 268–272 · DOI
  10. Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS (2015) Cold‐inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Mol Cell 57: 235–246 · DOI
  11. Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans‐Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE et al (2017) Adipose HIF‐1alpha causes obesity by suppressing brown adipose tissue thermogenesis. J Mol Med 95: 287–297 · DOI
  12. Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH et al (2014) IRF4 is a key thermogenic transcriptional partner of PGC‐1alpha. Cell 158: 69–83 · DOI
  13. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR et al (2012) Brown remodeling of white adipose tissue by SirT1‐dependent deacetylation of Ppargamma. Cell 150: 620–632 · DOI
  14. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM (2011) Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Investig 121: 96–105 · DOI
  15. Long J, Badal SS, Ye Z, Wang Y, Ayanga BA, Galvan DL, Green NH, Chang BH, Overbeek PA, Danesh FR (2016) Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Investig 126: 4205–4218 · DOI
  16. Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, Yamamoto T (2015) Post‐transcriptional stabilization of Ucp1 mRNA protects mice from diet‐induced obesity. Cell Rep 13: 2756–2767 · DOI
  17. Bandesh K, Prasad G, Giri AK, Kauser Y, Upadhyay M, Indico Basu A, Tandon N, Bharadwaj D (2019) Genome‐wide association study of blood lipids in Indians confirms universality of established variants. J Hum Genet 64: 573–587 · DOI · Paper page
  18. Artzt K, Wu JI (2010) STAR trek: an introduction to STAR family proteins and review of quaking (QKI). Adv Exp Med Biol 693: 1–24 · DOI
  19. Galarneau A, Richard S (2005) Target RNA motif and target mRNAs of the Quaking STAR protein. Nat Struct Mol Biol 12: 691–698 · DOI
  20. Yang G, Fu H, Zhang J, Lu X, Yu F, Jin L, Bai L, Huang B, Shen L, Feng Y et al (2010) RNA‐binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer. Gastroenterology 138: 231–240.e231–e235 · DOI
  21. Zhang Y, Lu Z, Ku L, Chen Y, Wang H, Feng Y (2003) Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism. EMBO J 22: 1801–1810 · DOI
  22. de Bruin RG, Shiue L, Prins J, de Boer HC, Singh A, Fagg WS, van Gils JM, Duijs JM, Katzman S, Kraaijeveld AO et al (2016) Quaking promotes monocyte differentiation into pro‐atherogenic macrophages by controlling pre‐mRNA splicing and gene expression. Nat Commun 7: 10846 · DOI
  23. Ichimura A, Hirasawa A, Poulain‐Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K et al (2012) Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483: 350–354 · DOI
  24. Jimenez V, Munoz S, Casana E, Mallol C, Elias I, Jambrina C, Ribera A, Ferre T, Franckhauser S, Bosch F (2013) In vivo adeno‐associated viral vector‐mediated genetic engineering of white and brown adipose tissue in adult mice. Diabetes 62: 4012–4022 · DOI
  25. Liu X, Magee D, Wang C, McMurphy T, Slater A, During M, Cao L (2014) Adipose tissue insulin receptor knockdown via a new primate‐derived hybrid recombinant AAV serotype. Mol Ther Methods Clin Dev 1. https://doi.org/10.1038/mtm.2013.8 · DOI
  26. Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M et al (2014) Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab 307: E262–E277 · DOI
  27. Rosell M, Kaforou M, Frontini A, Okolo A, Chan YW, Nikolopoulou E, Millership S, Fenech ME, MacIntyre D, Turner JO et al (2014) Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice. Am J Physiol 306: E945–E964
  28. Plaisier CL, Bennett BJ, He A, Guan B, Lusis AJ, Reue K, Vergnes L (2012) Zbtb16 has a role in brown adipocyte bioenergetics. Nutr Diabetes 2: e46 · DOI
  29. Larocque D, Pilotte J, Chen T, Cloutier F, Massie B, Pedraza L, Couture R, Lasko P, Almazan G, Richard S (2002) Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron 36: 815–829 · DOI
  30. Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM (2017) Crosstalk between KCNK3‐mediated ion current and adrenergic signaling regulates adipose thermogenesis and obesity. Cell 171: 836–848.e813 · DOI
  31. Sanchez‐Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM et al (2018) Brown fat AKT2 is a cold‐induced kinase that stimulates ChREBP‐mediated de novo lipogenesis to optimize fuel storage and thermogenesis. Cell Metab 27: 195–209.e196 · DOI
  32. Bauters D, Cobbaut M, Geys L, Van Lint J, Hemmeryckx B, Lijnen HR (2017) Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling. Mol Metab 6: 715–724 · DOI
  33. Xue B, Coulter A, Rim JS, Koza RA, Kozak LP (2005) Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol 25: 8311–8322 · DOI
  34. Xu D, Xu S, Kyaw AMM, Lim YC, Chia SY, Chee Siang DT, Alvarez‐Dominguez JR, Chen P, Leow MK, Sun L (2017) RNA binding protein Ybx2 regulates RNA stability during cold‐induced brown fat activation. Diabetes 66: 2987–3000 · DOI
  35. Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S et al (2017a) RNA‐binding protein PSPC1 promotes the differentiation‐dependent nuclear export of adipocyte RNAs. J Clin Investig 127: 987–1004 · DOI
  36. Huot ME, Richard S (2012) Stay lean without dieting: lose Sam68. Adipocyte 1: 246–249 · DOI
  37. Huot ME, Vogel G, Zabarauskas A, Ngo CT, Coulombe‐Huntington J, Majewski J, Richard S (2012) The Sam68 STAR RNA‐binding protein regulates mTOR alternative splicing during adipogenesis. Mol Cell 46: 187–199 · DOI
  38. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao TC et al (2015) Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 225: 181–189 · DOI
  39. Feng Y, Bankston A (2010) The star family member QKI and cell signaling. Adv Exp Med Biol 693: 25–36 · DOI
  40. Hondares E, Rosell M, Diaz‐Delfin J, Olmos Y, Monsalve M, Iglesias R, Villarroya F, Giralt M (2011) Peroxisome proliferator‐activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC‐1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J Biol Chem 286: 43112–43122 · DOI
  41. Lodhi IJ, Yin L, Jensen‐Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu‐Hsu F et al (2012) Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet‐induced obesity. Cell Metab 16: 189–201 · DOI
  42. Shan T, Liu W, Kuang S (2013) Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues. FASEB J 27: 277–287 · DOI
  43. Urs S, Harrington A, Liaw L, Small D (2006) Selective expression of an aP2/Fatty Acid Binding Protein 4‐Cre transgene in non‐adipogenic tissues during embryonic development. Transgenic Res 15: 647–653 · DOI
  44. Wang L, Zhai DS, Ruan BJ, Xu CM, Ye ZC, Lu HY, Jiang YH, Wang ZY, Xiang A, Yang Y et al (2017b) Quaking deficiency amplifies inflammation in experimental endotoxemia via the aryl hydrocarbon receptor/signal transducer and activator of transcription 1‐NF‐kappaB pathway. Front Immunol 8: 1754 · DOI
  45. Kusminski CM, Bickel PE, Scherer PE (2016) Targeting adipose tissue in the treatment of obesity‐associated diabetes. Nat Rev Drug Discovery 15: 639–660 · DOI · Paper page
  46. Favre D, Le Gouill E, Fahmi D, Verdumo C, Chinetti‐Gbaguidi G, Staels B, Caiazzo R, Pattou F, Le KA, Tappy L et al (2011) Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity. Diabetes 60: 3169–3174 · DOI
  47. Qi L, Saberi M, Zmuda E, Wang Y, Altarejos J, Zhang X, Dentin R, Hedrick S, Bandyopadhyay G, Hai T et al (2009) Adipocyte CREB promotes insulin resistance in obesity. Cell Metab 9: 277–286 · DOI
  48. Shabalina IG, Petrovic N, Kramarova TV, Hoeks J, Cannon B, Nedergaard J (2006) UCP1 and defense against oxidative stress: 4‐Hydroxy‐2‐nonenal effects on brown fat mitochondria are uncoupling protein 1‐independent. J Biol Chem 281: 13882–13893 · DOI
  49. Chen HC, Farese RV Jr (2002) Determination of adipocyte size by computer image analysis. J Lipid Res 43: 986–989 · DOI
  50. Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, Luo W, Chen J, Lu Z (2019) MOTS‐c peptide regulates adipose homeostasis to prevent ovariectomy‐induced metabolic dysfunction. J Mol Med 97: 473–485 · DOI
  51. Faye MD, Graber TE, Holcik M (2014) Assessment of selective mRNA translation in mammalian cells by polysome profiling. J Vis Exp 92: e52295

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Metadata

Authors
Lu, H., Ye, Z., Zhai, Y., Wang, L., Liu, Y., Wang, J., Zhang, W., Luo, W., Lu, Z., & Chen, J.
ORCID
Venue
The EMBO Reports
Publisher
Springer Science and Business Media LLC
Published
2019-12-23
Volume
21
Issue
1
ISSN
  • 1469-221X
  • 1469-3178
DOI
10.15252/embr.201947929
Cited by
29
References
2
Language
en
Licence
Funders
National Natural Science Foundation of China (31571215, 81330045, 31270843, 81730053)

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CoChat. (2026). Citation check: QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity. https://app.cochat.ai/papers/10.15252/embr.201947929
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Lu, H., Ye, Z., Zhai, Y., Wang, L., Liu, Y., Wang, J., Zhang, W., Luo, W., Lu, Z., & Chen, J. (2020). QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity. The EMBO Reports. https://doi.org/10.15252/embr.201947929