IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins
Open accessAbstract
Although variants in the IGF2BP2/IMP2 gene confer risk for type 2 diabetes, IMP2, an RNA binding protein, is not known to regulate metabolism. Imp2(-/-) mice gain less lean mass after weaning and have increased lifespan. Imp2(-/-) mice are highly resistant to diet-induced obesity and fatty liver and display superior glucose tolerance and insulin sensitivity, increased energy expenditure, and better defense of core temperature on cold exposure. Imp2(-/-) brown fat and Imp2(-/-) brown adipocytes differentiated in vitro contain more UCP1 polypeptide than Imp2(+/+) despite similar levels of Ucp1 mRNA; the Imp2(-/-)adipocytes also exhibit greater uncoupled oxygen consumption. IMP2 binds the mRNAs encoding Ucp1 and other mitochondrial components, and most exhibit increased translational efficiency in the absence of IMP2. In vitro IMP2 inhibits translation of mRNAs bearing the Ucp1 untranslated segments. Thus IMP2 limits longevity and regulates nutrient and energy metabolism in the mouse by controlling the translation of its client mRNAs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mice subjected to fasting display decreased IMP2 protein in their livers and white adipose tissue.
“Mice subjected to fasting display decreased IMP2 protein in their livers and white adipose tissue [40].”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [40]
The Results section, “IMP2 abundance is regulated by nutrition” (Fig. 1A–B; page unavailable), reports that an overnight fast decreases IMP2 abundance in the liver. It does not report a fasting-related decrease in white adipose tissue; instead, it says a high-fat diet increases IMP2 abundance there. (LLM, conf=0.90)
Experimental — accuracy not yet measuredIMP2 expression is impacted by diet and age.
“IMP2 expression is impacted by diet and age.”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · cited 1× · see citing works
“Susceptibility to type 2 diabetes mellitus (T2DM) is strongly influenced by both environmental (Knowler et al., 2002) and C genetic factors (DIAGRAM Consortium, 2014).”
BackgroundBrown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · cited 1× · see citing works
“One of the first SNPs found by GWAS for T2DM is located in intron 2 of the gene encoding the RNA binding protein, IGF2 mRNA binding protein 2, abbrevi- ated IGF2BP2 or IMP2 (Saxena et al., 2007; Zeggini et al., 2007; Scott et al., 2007).”
BackgroundSelf-citationA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753 · see citing works
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works
Weight gain as a risk factor for clinical diabetes mellitus in women
Colditz, G. A., Willett, W. C., Rotnitzky, A., & Manson, J. E. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-7-199504010-00001 · Cited by 2,064 · see citing works
Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects
Larsen, S., Nielsen, J., Hansen, C. N., Nielsen, L. B., Wibrand, F., Stride, N., Schroder, H. D., Boushel, R., Helge, J. W., Dela, F., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.230185 · Cited by 1,180 · cited 2× · see citing works
“Inasmuch as CS correlates much more closely with mitochondrial fractional area determined by electron microscopy than does mitochondrial DNA (Larsen et al., 2012), these data indicate that mitochondrial oxidative capacity is not different in the Imp2 / .”
BackgroundRibosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Mahajan, A., Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., et al. (2014) · Nature Genetics · doi:10.1038/ng.2897 · Cited by 1,034 · see citing works
Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria
Fedorenko, A., Lishko, P. V., & Kirichok, Y. (2012) · Cell · doi:10.1016/j.cell.2012.09.010 · Cited by 968 · see citing works
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.09.036 · Cited by 945 · see citing works
Nielsen, J., Christiansen, J., Lykke-Andersen, J., Johnsen, A. H., Wewer, U. M., & Nielsen, F. C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1262 · Cited by 721 · see citing works
Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature · doi:10.1038/nature08262 · Cited by 703 · see citing works
Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N. L., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 682 · see citing works
Nonshivering thermogenesis and its adequate measurement in metabolic studies
Cannon, B., & Nedergaard, J. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.050989 · Cited by 677 · cited 5× · see citing works
“Mice maintained at 22 C–23 C, far from their thermoneutral temperature (28 C–30 C), are partially cold adapted, a response that involves increased mitochondrial biogenesis and UCP1 expression in brown fat (Cannon and Nedergaard, 2004, 2011).”
BackgroundResultInfluentialThe Regulation and Physiology of Mitochondrial Proton Leak
Divakaruni, A. S., & Brand, M. D. (2011) · Physiology · doi:10.1152/physiol.00046.2010 · Cited by 484 · see citing works
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsPreprint
Janiszewska, M., Suvà, M. L., Riggi, N., Houtkooper, R. H., Auwerx, J. H., Clément‐Schatlo, V., Radovanovic, I., Rheinbay, E., Provero, P., & Stamenkovic, I. (2012) · Genes & Development · doi:10.1101/gad.188292.112 · Cited by 451 · see citing works
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
da Silva, C. C. C., Cerqueira, F. M., Barbosa, L. F., de Medeiros, M. H. G., & Kowaltowski, A. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00407.x · Cited by 346 · see citing works
Wu, J., Liu, J., Chen, E. B., Wang, J., Cao, L., Narayan, N., Fergusson, M. M., Rovira, I. I., Allen, M. D., Springer, D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.030 · Cited by 333 · see citing works
Marselli, L., Thorne, J., Dahiya, S., Sgroi, D. C., Sharma, A., Bonner-Weir, S., Marchetti, P., & Weir, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011499 · Cited by 313 · see citing works
Block, B. A. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.002535 · Cited by 281 · see citing works
VICKZ proteins: a multi‐talented family of regulatory RNA‐binding proteins
Yisraeli, J. K. (2005) · Biology of the Cell · doi:10.1042/bc20040151 · Cited by 231 · see citing works
Statistical methods for testing effects on “maximum lifespan”
Wang, C., Li, Q., Redden, D. T., Weindruch, R., & Allison, D. B. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.003 · Cited by 208 · see citing works
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry
Dai, N., Rapley, J., Angel, M., Yanik, M. F., Blower, M. D., & Avruch, J. (2011) · Genes & Development · doi:10.1101/gad.2042311 · Cited by 208 · see citing works
Self-citationKaiyala, K. J., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db10-0909 · Cited by 156 · see citing works
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
Groenewoud, M. J., Dekker, J. M., Fritsche, A., Reiling, E., Nijpels, G., Heine, R. J., Maassen, J. A., Machicao, F. E., Schäfer, S., Häring, H., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1083-z · Cited by 135 · see citing works
Protein targeting to subcellular organelles via mRNA localization
Weis, B. L., Schleiff, E., & Zerges, W. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.04.004 · Cited by 117 · see citing works
Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
Gates, A. C., Bernal‐Mizrachi, C., Chinault, S. L., Chu, F., Schneider, J. G., Coleman, T., Malone, J. P., Townsend, R. R., Chakravarthy, M. V., & Semenkovich, C. F. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.010 · Cited by 113 · see citing works
Biochemical Analyses of the Electron Transport Chain Complexes by Spectrophotometry
Frazier, A. E., & Thorburn, D. R. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-504-6_4 · Cited by 110 · see citing works
Self-citationTurturro, A., Duffy, P. H., Hass, B. S., Kodell, R. L., & Hart, R. W. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.11.b379 · Cited by 101 · see citing works
Dai, N., Christiansen, J., Nielsen, F. C., & Avruch, J. (2013) · Genes & Development · doi:10.1101/gad.209130.112 · Cited by 99 · see citing works
Self-citationMammalian models of extended healthy lifespan
Selman, C., & Withers, D. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0243 · Cited by 71 · see citing works
Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype
Tybl, E., Shi, F.-D., Kessler, S. M., Tierling, S., Walter, J., Bohle, R. M., Wieland, S., Zhang, J., Tan, E. M., & Kiemer, A. K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.08.034 · Cited by 65 · see citing works
Kessler, S. M., Pokorny, J., Zimmer, V., Laggai, S., Lammert, F., Bohle, R. M., & Kiemer, A. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00005.2012 · Cited by 64 · see citing works
Longevity and lifespan control in mammals: Lessons from the mouse
Chen, Y., Wu, C.-Y., Kao, C., & Tsai, T. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.07.003 · Cited by 40 · see citing works
Variation in IGF2BP2 Interacts With Adiposity to Alter Insulin Sensitivity in Mexican Americans
Li, X., Allayee, H., Xiang, A. H., Trigo, E., Hartiala, J., Lawrence, J. M., Buchanan, T. A., & Watanabe, R. M. (2009) · Obesity · doi:10.1038/oby.2008.593 · Cited by 40 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Screening for functional circular RNAs using the CRISPR–Cas13 system
Li, S., Li, X., Xue, W., Zhang, L., Yang, L.-Z., Cao, S.-M., Lei, Y.-N., Liu, C.-X., Guo, S.-K., Shan, L., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-01011-4 · Cited by 355 · see citing works
Degrauwe, N., Suvà, M.-L., Janiszewska, M., Riggi, N., & Stamenkovic, I. (2016) · Genes & Development · doi:10.1101/gad.287540.116 · Cited by 324 · see citing works
The plasticity of mRNA translation during cancer progression and therapy resistance
Fabbri, L., Chakraborty, A., Robert, C., & Vagner, S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00380-y · Cited by 273 · see citing works
The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
Wang, J., Chen, L., & Qiang, P. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01799-x · Cited by 217 · see citing works
Epitranscriptomics in liver disease: Basic concepts and therapeutic potential
Zhao, Z., Meng, J., Su, R. J., Zhang, J., Chen, J., Ma, X., & Xia, Q. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.009 · Cited by 166 · see citing works
RNA Binding Proteins in Intestinal Epithelial Biology and Colorectal Cancer
Chatterji, P., & Rustgi, A. K. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.03.008 · Cited by 165 · see citing works
IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives
Mancarella, C., & Scotlandi, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00363 · Cited by 161 · see citing works
The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells
Cao, J., Mu, Q., & Huang, H. (2018) · Stem Cells International · doi:10.1155/2018/4217259 · Cited by 158 · see citing works
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer
Ramesh-Kumar, D., & Guil, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.05.009 · Cited by 151 · see citing works
Conway, A. E., Nostrand, E. L. V., Pratt, G. A., Aigner, S., Wilbert, M. L., Sundararaman, B., Freese, P., Lambert, N. J., Sathe, S., Liang, T. Y., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.052 · Cited by 149 · see citing works
Wang, X., Ji, Y., Feng, P., Liu, R., Li, G., Zheng, J., Xue, Y., Wei, Y., Ji, C., Chen, D., et al. (2021) · Advanced Science · doi:10.1002/advs.202100209 · Cited by 147 · see citing works
Type 2 diabetes: genetic data sharing to advance complex disease research
Flannick, J. A., & Florez, J. C. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.56 · Cited by 145 · see citing works
Yu, D., Pan, M., Li, Y., Lu, T., Wang, Z., Liu, C., & Hu, G. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02212-1 · Cited by 123 · see citing works
Bonàs‐Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastián, D., Rodríguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortés-Sánchez, P., González, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02380-9 · Cited by 122 · see citing works
Kim, C., Kang, D., Lee, E. K., & Lee, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2062384 · Cited by 116 · see citing works
The Diverse Functions of IMP2/IGF2BP2 in Metabolism
Dai, N. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.05.007 · Cited by 114 · see citing works
Self-citationGenome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
Huang, L. O., Rauch, A., Mazzaferro, E., Preuss, M. H., Carobbio, S., Bayrak, Ç. S., Chami, N., Wang, Z., Schick, U. M., Yang, N. Y., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00346-2 · Cited by 113 · see citing works
Transcriptional regulation of the uncoupling protein-1 gene
Villarroya, F., Peyrou, M., & Giralt, M. (2017) · Biochimie · doi:10.1016/j.biochi.2016.09.017 · Cited by 108 · see citing works
Ye, S., Song, W., Xu, X., Zhao, X., & Yang, L. (2016) · FEBS Letters · doi:10.1002/1873-3468.12205 · Cited by 108 · see citing works
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Cheng, J., Demeulemeester, J., Wedge, D. C., Vollan, H. K. M., Pitt, J. J., Russnes, H. G., Pandey, B. P., Nilsen, G., Nord, S., Bignell, G. R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01355-0 · Cited by 105 · see citing works
The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer
Sun, C., Cao, D., Du, B.-B., Chen, C., & Liu, D. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.70458 · Cited by 103 · see citing works
Dai, N., Ji, F., Wright, J., Minichiello, L., Sadreyev, R., & Avruch, J. (2017) · eLife · doi:10.7554/elife.27155 · Cited by 103 · see citing works
Self-citationRNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation
Liu, H., Muhammad, T., Guo, Y., Li, M., Sha, Q., Zhang, C., Liu, H., Zhao, S., Zhao, H., Zhang, H., et al. (2019) · Advanced Science · doi:10.1002/advs.201900295 · Cited by 97 · see citing works
The RNA-binding protein HuR is a negative regulator in adipogenesis
Siang, D. T. C., Lim, Y. C., Kyaw, A. M. M., Khaing, N. W., Chia, S. Y., Degirmenci, U., Hu, X., Tan, B. C., Arcinas, C., Sun, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14001-8 · Cited by 96 · see citing works
Zhou, Y., Yan, J., Huang, H., Liu, L., Ren, L., Hu, J., Jiang, X., Zheng, Y., Xu, L., Zhong, F., et al. (2024) · Cell Death & Disease · doi:10.1038/s41419-024-06509-9 · Cited by 92 · see citing works
miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2
Wu, L., Song, W., Xie, Y., Hu, L., Hou, X., Wang, R., Gao, Y., Zhang, J.-N., Zhang, L., Li, W., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0045-0 · Cited by 92 · see citing works
IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype
Kessler, S. M., Laggai, S., Barghash, A., Schultheiss, C. S., Lederer, E., Artl, M., Helms, V., Haybaeck, J., & Kiemer, A. K. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.241 · Cited by 90 · see citing works
Bechara, R., Amatya, N., Bailey, R. D., Li, Y., Aggor, F. E. Y., Li, D.-D., Jawale, C. V., Coleman, B. M., Dai, N., Gokhale, N. S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abd1287 · Cited by 89 · see citing works
Self-citationDuan, M., Liu, H., Xu, S., Yang, Z., Zhang, F., Wang, G., Wang, Y., Zhao, S., & Jiang, X. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.017 · Cited by 87 · see citing works
Self-citationThe Structural Basis for RNA Selectivity by the IMP Family of RNA-Binding Proteins
Biswas, J., Patel, V. L., Bhaskar, V., Chao, J. A., Singer, R. H., & Eliscovich, C. (2019) · Nature Communications · doi:10.1038/s41467-019-12193-7 · Cited by 84 · see citing works
m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer
Petri, B. J., & Klinge, C. M. (2022) · Journal of Molecular Endocrinology · doi:10.1530/jme-22-0110 · Cited by 74 · see citing works
Huang, S., Wu, Z., Cheng, Y., Wei, W., & Hao, L. (2019) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmz048 · Cited by 73 · see citing works
First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy
Dahlem, C., Abuhaliema, A., Kessler, S. M., Kröhler, T., Zoller, B. G. E., Chanda, S., Wu, Y., Both, S., Müller, F., Lepikhov, K., et al. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.1c00833 · Cited by 70 · see citing works
Barghash, A., Golob‐Schwarzl, N., Helms, V., Haybaeck, J., & Kessler, S. M. (2016) · Oncotarget · doi:10.18632/oncotarget.10439 · Cited by 66 · see citing works
Carneiro, M., Hu, D., Archer, J. P., Feng, C., Afonso, S., Chen, C., Blanco, J., Garreau, H., Boucher, S., Ferreira, P. G., et al. (2016) · Genetics · doi:10.1534/genetics.116.196667 · Cited by 65 · see citing works
Ravanidis, S., Kattan, F.-G., & Doxakis, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082280 · Cited by 65 · see citing works
Gut Microbiota Composition Is Associated with the Global DNA Methylation Pattern in Obesity
Ramos-Molina, B., Sánchez-Alcoholado, L., Cabrera-Mulero, A., Lopez-Dominguez, R., Carmona-Saez, P., Garcia-Fuentes, E., Moreno-Indias, I., & Tinahones, F. J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00613 · Cited by 64 · see citing works
Lin28 and let-7 in the Metabolic Physiology of Aging
Jun‐Hao, E. T., Gupta, R., & Shyh‐Chang, N. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.006 · Cited by 64 · see citing works
The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome
Li, M., Zhao, H., Zhao, S., Wei, D., Zhao, Y., Huang, T., Muhammad, T., Yan, L., Gao, F., Li, L., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00544 · Cited by 64 · see citing works
A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes
Mercader, J. M., Liao, R. G., Bell, A. D., Dymek, Z., Estrada, K., Tukiainen, T., Huerta‐Chagoya, A., Moreno-Macías, H., Jablonski, K. A., Hanson, R. L., et al. (2017) · Diabetes · doi:10.2337/db17-0187 · Cited by 62 · see citing works
Self-citationThe biological function of IGF2BPs and their role in tumorigenesis
Du, Q., Zhu, Z., & Pei, D. (2021) · Investigational New Drugs · doi:10.1007/s10637-021-01148-9 · Cited by 61 · see citing works
Regué, L., Zhao, L., Ji, F., Wang, H., Avruch, J., & Dai, N. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101209 · Cited by 60 · see citing works
Self-citationPerochon, J., Yu, Y., Aughey, G., Medina, A. B., Southall, T. D., & Cordero, J. B. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00676-z · Cited by 58 · see citing works
Regué, L., Minichiello, L., Avruch, J., & Dai, N. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008778 · Cited by 58 · see citing works
Self-citationSuo, M., Rommelfanger, M. K., Chen, Y., Amro, E. M., Han, B., Chen, Z., Szafranski, K., Chakkarappan, S. R., Boehm, B. O., MacLean, A. L., et al. (2022) · Blood · doi:10.1182/blood.2021012197 · Cited by 57 · see citing works
Peng, T., Liu, M., Hu, L., Guo, D., Wang, D., Qi, B., Ren, G., Hu, C., Zhang, F., Chun, H. J., et al. (2022) · Biology Direct · doi:10.1186/s13062-022-00346-6 · Cited by 57 · see citing works
Genes associated with Type 2 Diabetes and vascular complications
Montesanto, A., Bonfigli, A. R., Crocco, P., Garagnani, P., Luca, M. D., Boemi, M., Marasco, E., Pirazzini, C., Giuliani, C., Franceschi, C., et al. (2018) · Aging · doi:10.18632/aging.101375 · Cited by 56 · see citing works
Zhang, X., Xue, C., Lin, J. J., Ferguson, J. F., Weiner, A. K., Liu, W., Han, Y., Hinkle, C. C., Li, W., Jiang, H., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar5987 · Cited by 55 · see citing works
Central IGF1 improves glucose tolerance and insulin sensitivity in mice
Hong, H., Cui, Z.-Z., Zhu, L., Fu, S.-P., Rossi, M., Cui, Y.-H., & Zhu, B.-M. (2017) · Nutrition & Diabetes · doi:10.1038/s41387-017-0002-0 · Cited by 54 · see citing works
The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders
Zaiou, M. (2020) · Cells · doi:10.3390/cells9061473 · Cited by 50 · see citing works
Assessment of mitochondrial respiratory chain enzymes in cells and tissues
Frazier, A. E., Vincent, A. E., Turnbull, D. M., Thorburn, D. R., & Taylor, R. W. (2019) · Methods in cell biology · doi:10.1016/bs.mcb.2019.11.007 · Cited by 49 · see citing works
Self-citationCao, J., Yan, W., Ma, X., Huang, H., & YAN, H. H. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab391 · Cited by 47 · see citing works
Xia, J., Chu, C., Li, W., Chen, H., Xie, W., Cheng, R., Hu, K., & Li, X. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.68438 · Cited by 45 · see citing works
RNA-binding proteins in cancer drug discovery
Bertoldo, J. B., Müller, S., & Hüttelmaier, S. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103580 · Cited by 44 · see citing works
Panga, V., Kallor, A. A., Nair, A., Harshan, S., & Raghunathan, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224632 · Cited by 41 · see citing works
RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation
Xu, D., Xu, S., Kyaw, A. M. M., Lim, Y. C., Chia, S. Y., Siang, D. T. C., Alvarez‐Dominguez, J. R., Chen, P., Leow, M. K., & Sun, L. (2017) · Diabetes · doi:10.2337/db17-0655 · Cited by 40 · see citing works
Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2
Jiang, Y., Peng, J., Song, J., He, J., Jiang, M., Wang, J., Ma, L., Wang, Y., Lin, M., Wu, H., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00488-3 · Cited by 39 · see citing works
Self-citationKessler, S. M., Lederer, E., Laggai, S., Golob‐Schwarzl, N., Hosseini, K., Petzold, J., Schweiger, C., Reihs, R., Keil, M., Hoffmann, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21116 · Cited by 39 · see citing works
Yoshizawa, T., Sato, Y., Sobuz, S. U., Mizumoto, T., Tsuyama, T., Karim, M. F., Miyata, K., Tasaki, M., Yamazaki, M., Kariba, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35219-z · Cited by 37 · see citing works
Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
Azarova, I. E., Polonikov, A., & Klyosova, E. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054738 · Cited by 37 · see citing works
IGF2BP2 promotes cancer progression by degrading the RNA transcript encoding a v-ATPase subunit
Latifkar, A., Wang, F., Mullmann, J. J., Panizza, E., Fernandez, I. R., Lu, L., Miller, A. D., Fischbach, C., Weiss, R. S., Lin, H., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200477119 · Cited by 35 · see citing works
RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function
Zhang, P., Wu, W., Ma, C., Du, C., Huang, Y., Xu, H., Li, C., Cheng, X., Hao, R., & Xu, Y. (2022) · Cells · doi:10.3390/cells11152357 · Cited by 35 · see citing works
The Emerging Role of SIRT7 in Glucose and Lipid Metabolism
Yamagata, K., Mizumoto, T., & Yoshizawa, T. (2023) · Cells · doi:10.3390/cells13010048 · Cited by 33 · see citing works
Xiao, P., Meng, Q., Liu, Q., Lang, Q., Yin, Z., Li, G., Li, Z., Xu, Y., Yu, Z., Geng, Q., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216075 · Cited by 33 · see citing works
Shao, J., Wang, M., Zhang, A., Liu, Z., Jiang, G., Tang, T., Wang, J., Jia, X., & Lai, S. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04899-1 · Cited by 32 · see citing works
Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels
Subramanian, S., Serbulea, V., Upchurch, C. M., Polanowska‐Grabowska, R., Mendu, S. K., Sahu, S., Jayaguru, P., Aylor, K. W., Chordia, M. D., Steinberg, L., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101130 · Cited by 32 · see citing works
CPEB2‐dependent translation of long 3′‐UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue
Chen, H., Hsu, C., & Huang, Y. (2018) · The EMBO Journal · doi:10.15252/embj.201899071 · Cited by 31 · see citing works
QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity
Lu, H., Ye, Z., Zhai, Y., Wang, L., Liu, Y., Wang, J., Zhang, W., Luo, W., Lu, Z., & Chen, J. (2019) · EMBO Reports · doi:10.15252/embr.201947929 · Cited by 30 · see citing works
Zhou, Z., Chen, S., Wu, T., Chen, Y., Cao, Y., Huang, Y., & Liu, D. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30919 · Cited by 30 · see citing works
RNA-binding proteins in vascular inflammation and atherosclerosis
Sachse, M., Tual-Chalot, S., Ciliberti, G., Amponsah-Offeh, M., Stamatelopoulos, K., Gatsiou, A., & Stellos, K. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.01.008 · Cited by 29 · see citing works
VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice
Rosenfeld, Y. B.-Z., Krumbein, M., Yeffet, A., Schiffmann, N., Mishalian, I., Pikarsky, E., Oberman, F., Fridlender, Z. G., & Yisraeli, J. K. (2019) · Oncogene · doi:10.1038/s41388-019-0715-8 · Cited by 29 · see citing works
Li, Y., Zhang, Y., Zhang, T., Ping, X., Wang, D., Chen, Y., Yu, J., Liu, C., Liu, Z., Zheng, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202300436 · Cited by 28 · see citing works
RNA binding proteins in senescence: A potential common linker for age-related diseases?
Varesi, A., Campagnoli, L. I. M., Barbieri, A., Rossi, L., Ricevuti, G., Esposito, C., Chirumbolo, S., Marchesi, N., & Pascale, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101958 · Cited by 28 · see citing works
Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
Chen, B. H., Hivert, M., Peters, M. J., Pilling, L. C., Hogan, J., Pham, L., Harries, L. W., Fox, C. S., Bandinelli, S., Dehghan, A., et al. (2016) · Diabetes · doi:10.2337/db16-0470 · Cited by 28 · see citing works
Ji, L., Zhao, Y., He, L., Zhao, J., Gao, T., Liu, F., Qi, B., Kang, F., Wang, G., Zhao, Y., et al. (2021) · Advanced Science · doi:10.1002/advs.202002794 · Cited by 27 · see citing works
Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A
Cannavino, J., Shao, M., An, Y., Bezprozvannaya, S., Chen, S., Kim, J., Xu, L., McAnally, J., Scherer, P. E., Liu, N., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104650118 · Cited by 27 · see citing works
Decoding m6A mRNA methylation by reader proteins in liver diseases
Sun, L., Chen, X., Zhu, S., Wang, J., Diao, S., Liu, J., Xu, J., Li, X., Sun, Y.-Y., Huang, C., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.054 · Cited by 27 · see citing works
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases
Salem, E., Vonberg, A. D., Borra, V. J., Gill, R. K., & Nakamura, T. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00106 · Cited by 26 · see citing works
IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories
Preitner, N., Quan, J., Li, X., Nielsen, F. C., & Flanagan, J. G. (2016) · Development · doi:10.1242/dev.128348 · Cited by 25 · see citing works
Ouyang, J., Li, J., Li, D., Jiang, J., Hao, T., Xia, Y., Lu, X., Zhang, C., & He, Y. (2022) · Cancers · doi:10.3390/cancers14215381 · Cited by 25 · see citing works
Zhu, J., Guo, D., Lv, H., Liang, Z., Song, J., & Zeng, W. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70551 · Cited by 24 · see citing works
Li, X. Q., Du, Y., Xue, C., Kang, X., Sun, C., Peng, H., Fang, L., Han, Y., Xu, X., & Zhao, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108970 · Cited by 22 · see citing works
The regulatory landscape of 5′ UTRs in translational control during zebrafish embryogenesis
Reimão-Pinto, M. M., Castillo-Hair, S. M., Seelig, G., & Schier, A. F. (2025) · Developmental Cell · doi:10.1016/j.devcel.2024.12.038 · Cited by 21 · see citing works
Whole genome sequence analysis of the TALLYHO/Jng mouse
Denvir, J., Bošković, G., Fan, J., Primerano, D. A., Parkman, J. K., & Kim, J. H. (2016) · BMC Genomics · doi:10.1186/s12864-016-3245-6 · Cited by 20 · see citing works
Methylation of Hypothalamic Tsc1‐mTOR Signaling in Regulation of Obesity and Obesity Resistance
Wang, Y., Diao, S., Hu, M., & Zhang, L. (2020) · BioMed Research International · doi:10.1155/2020/8723869 · Cited by 20 · see citing works
Self-citationAlvarez‐Dominguez, J. R., Winther, S., Hansen, J. B., Lodish, H. F., & Knoll, M. (2021) · iScience · doi:10.1016/j.isci.2021.103680 · Cited by 19 · see citing works
A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
Mestres‐Arenas, A., Villarroya, J., Giralt, M., Villarroya, F., & Peyrou, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.714530 · Cited by 19 · see citing works
The RNA-Binding Protein IMP2 Drives a Stromal-Th17 Cell Circuit in Autoimmune Neuroinflammation
Bechara, R., Amatya, N., Majumder, S., Zhou, C., Li, Y., Liu, Q., McGeachy, M. J., & Gaffen, S. L. (2022) · JCI Insight · doi:10.1172/jci.insight.152766 · Cited by 18 · see citing works
Xu, X., Shen, H., Yu, M., Du, M., & Li, X. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.01.016 · Cited by 18 · see citing works
Krumbein, M., Oberman, F., Cinnamon, Y., Golomb, M., May, D., Vainer, G. W., Belzer, V., Meir, K. S., Fridman, I., Haybaeck, J., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05547-x · Cited by 18 · see citing works
Frau, F., Crowther, D. J., Ruetten, H., & Allebrandt, K. V. (2017) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.03.004 · Cited by 18 · see citing works
IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice
Bi, Y., Li, C., Liu, L., Zhou, J., Li, Z., Deng, H., Wu, C., Han, Y., Song, Y., Tan, Y., et al. (2017) · 中国科学通报：英文版 · doi:10.1016/j.scib.2017.07.011 · Cited by 18 · see citing works
Azarova, I. E., Klyosova, E. Y., Лазаренко, В. А., Konoplya, A. I., & Polonikov, A. (2020) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-020-04698-9 · Cited by 17 · see citing works
Robinson, E. L., Bagchi, R. A., Major, J. L., Bergman, B. C., Matsuda, J. L., & McKinsey, T. A. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168192 · Cited by 17 · see citing works
Lu, F., Chen, W., Jiang, T., Cheng, C., Wang, B., Lu, Z., Huang, G., Qiu, J.-M., Wei, W., Yang, M., et al. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11177 · Cited by 17 · see citing works
Xu, Z., He, B., Jiang, Y., Zhang, M., Tian, Y., Zhou, N., Zhou, Y., Chen, M., Tang, M., Gao, J., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108987 · Cited by 17 · see citing works
IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish
Li, M., Rong, X., Lu, L., Li, Y., Yao, K., Ge, W., & Duan, C. (2021) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2021.113875 · Cited by 16 · see citing works
Liu, F., Cao, Y., Zhang, C., & Su, H. (2023) · The FASEB Journal · doi:10.1096/fj.202300146r · Cited by 16 · see citing works
Chen, Z., Zhong, X., Xia, M. H., Liu, C., Tang, W., Liu, G., Yi, Y., Guo, Y., Jiang, Q., Zu, X., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07097-4 · Cited by 16 · see citing works
- Authors
- Dai, N., Zhao, L., Wrighting, D., Krämer, D., Majithia, A., Wang, Y., Cracan, V., Borges-Rivera, D., Mootha, V. K., Nahrendorf, M., Thorburn, D. R., Minichiello, L., Altshuler, D., & Avruch, J.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- European Molecular Biology Laboratory (IT)
- Massachusetts General Hospital (US)
- Royal Children's Hospital (AU)
- University of Oxford (GB)
- Corresponding author
- Altshuler, David
- Avruch, Joseph
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 21
- Issue
- 4
- Pages
- 609-621
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4663978
- OpenAlex
- W2019615270
- Cited by
- 188
- References
- 38
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 17 · 2023: 19 · 2022: 36 · 2021: 21 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 1
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Health and Medical Research Council
- National Institute of General Medical Sciences (T32GM007287)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057521, R37DK017776, R37DK17776, P30DK043351, P30DK040561)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- IGF2BP2, RNA-binding proteins, diet-induced obesity, brown adipocytes, UCP1, mitochondrial translation, translational regulation, mRNA untranslated regions, energy expenditure, glucose tolerance, insulin sensitivity, hepatic steatosis, lifespan, cold tolerance, type 2 diabetes risk
- MeSH terms
- Uncoupling Protein 1, Analysis of Variance, Animals, Base Sequence, Body Temperature Regulation, Adipose Tissue, Brown, Energy Metabolism, Gene Expression Regulation, Insulin Resistance, Ion Channels, Molecular Sequence Data, Obesity, RNA-Binding Proteins, Sequence Analysis, RNA, Mice, Knockout, Mitochondrial Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
