Cited by 856Bacterial Genetics and BiotechnologyAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in Bacteria

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Antibiotic resistance and persistence—Implications for human health and treatment perspectives

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Huemer, Markus, Mairpady Shambat, Srikanth, Brugger, Silvio D, Zinkernagel, Annelies S·2020·The EMBO Reports

DOI 10.15252/embr.202051034PMC PMC7726816

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Abstract

Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of treatment failure and relapsing infections. They are thus important drivers of increased morbidity and mortality rates resulting in growing healthcare costs. Antibiotic resistance is readily identifiable with standard microbiological assays, and the threat imposed by antibiotic resistance has been well recognized. Measures aiming to reduce resistance development and spreading of resistant bacteria are being enforced. However, the phenomenon of bacteria surviving antibiotic exposure despite being fully susceptible, so-called antibiotic persistence, is still largely underestimated. In contrast to antibiotic resistance, antibiotic persistence is difficult to measure and therefore often missed, potentially leading to treatment failures. In this review, we focus on bacterial mechanisms allowing evasion of antibiotic killing and discuss their implications on human health. We describe the relationship between antibiotic persistence and bacterial heterogeneity and discuss recent studies that link bacterial persistence and tolerance with the evolution of antibiotic resistance. Finally, we review persister detection methods, novel strategies aiming at eradicating bacterial persisters and the latest advances in the development of new antibiotics.

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Items 201–275 of 275

Identification of a Novel Genomic Island Conferring Resistance to Multiple Aminoglycoside Antibiotics in Campylobacter coli
Qin, S., Wang, Y., Zhang, Q., Chen, X., Shen, Z., Deng, F., Wu, C., & Shen, J. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00809-12 · Cited by 105
Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection
Loss, G., Martins-Simões, P., Valour, F., Côrtes, M. F., Gonzaga, L., Bergot, M., Trouillet‐Assant, S., Josse, J., Diot, A., Ricci, E. P., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00363 · Cited by 103
Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis
Hansen, S., Vulić, M., Min, J., Yen, T.-J., Schumacher, M. A., Brennan, R. G., & Lewis, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039185 · Cited by 101
Triggering the stringent response: signals responsible for activating (p)ppGpp synthesis in bacteria
Irving, S. E., & Corrigan, R. M. (2018) · Microbiology · doi:10.1099/mic.0.000621 · Cited by 101
Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in a children's hospital in Beijing, China
Wu, D., Wang, Q., Yang, Y., Geng, W., Wang, Q., Yu, S., Yao, K., Yuan, L., & Shen, X. (2010) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2009.12.006 · Cited by 100
Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus
Schaaff, F., Bierbaum, G., Baumert, N., Bartmann, P., & Sahl, H. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00282 · Cited by 98
Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase
De, S. K., Stebbins, J. L., Chen, L., Riel-Mehan, M. M., Machleidt, T., Dahl, R. S., Yuan, H., Emdadi, A., Barile, E., Chen, V., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801503n · Cited by 95
Persistent Bacterial Infections
(2000) · ASM Press eBooks · doi:10.1128/9781555818104 · Cited by 94
Expression of multidrug resistance efflux pump genes in clinical and environmental isolates of Staphylococcus aureus
Kosmidis, C., Schindler, B. D., Jacinto, P. L., Patel, D., Bains, K., Seo, S. M., & Kaatz, G. W. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.04.014 · Cited by 94
XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms
Ooi, N., Miller, K., Randall, C. P., Rhys‐Williams, W., Love, W. C., & Chopra, I. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp409 · Cited by 94
Carbapenem-Resistant Klebsiella pneumoniae: Microbiology Key Points for Clinical Practice
Reyes, J., Aguilar, A. C., & Caicedo, A. (2019) · International Journal of General Medicine · doi:10.2147/ijgm.s214305 · Cited by 92
Current perspectives on tigecycline resistance in Enterobacteriaceae: susceptibility testing issues and mechanisms of resistance
Pournaras, S., Koumaki, V., Spanakis, N., Gennimata, V., & Tsakris, A. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.04.017 · Cited by 91
Inactivation of thyA in Staphylococcus aureus Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene Expression
Kriegeskorte, A., Block, D., Drescher, M., Windmüller, N., Mellmann, A., Baum, C., Neumann, C., Lorè, N. I., Bragonzi, A., Liebau, E., et al. (2014) · mBio · doi:10.1128/mbio.01447-14 · Cited by 89
In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance
Haunreiter, V. D., Boumasmoud, M., Häffner, N., Wipfli, D., Leimer, N., Rachmühl, C., Kühnert, D., Achermann, Y., Zbinden, R., Benussi, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09053-9 · Cited by 89
Self-citation
Antibiotic use and resistance?proving the obvious
Turnidge, J. D., & CHRISTIANSEN, K. (2005) · The Lancet · doi:10.1016/s0140-6736(05)70770-4 · Cited by 89
Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis
Gilligan, P. H., Gage, P. A., Welch, D. F., Muszynski, M. J., & Wait, K. J. (1987) · Journal of Clinical Microbiology · doi:10.1128/jcm.25.7.1258-1261.1987 · Cited by 87
Porin alterations present in non-carbapenemase-producing Enterobacteriaceae with high and intermediate levels of carbapenem resistance in Chile
Wozniak, A., Villagra, N. A., Undabarrena, A., Gallardo, N., Keller, N., Moraga, M., Román, J. C. B., Mora, G. C., & García, P. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045799-0 · Cited by 86
Colistin Heteroresistance in Enterobacter cloacae Is Associated with Cross-Resistance to the Host Antimicrobial Lysozyme
Napier, B. A., Band, V. I., Burd, E. M., & Weiss, D. S. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02432-14 · Cited by 86
NonstableStaphylococcus aureusSmall-Colony Variants Are Induced by Low pH and Sensitized to Antimicrobial Therapy by Phagolysosomal Alkalinization
Leimer, N., Rachmühl, C., Marques, M. P., Bahlmann, A. S., Furrer, A., Eichenseher, F., Seidl, K., Matt, U., Loessner, M. J., Schuepbach, R. A., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv388 · Cited by 86
Self-citation
Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus
Röhrig, C., Huemer, M., Lorgé, D., Luterbacher, S., Phothaworn, P., Schefer, C., Sobieraj, A. M., Zinsli, L. V., Shambat, S. M., Leimer, N., et al. (2020) · mBio · doi:10.1128/mbio.00209-20 · Cited by 85
Self-citation
Clinical Characteristics Associated with Isolation of Small-Colony Variants of Staphylococcus aureus and Pseudomonas aeruginosa from Respiratory Secretions of Patients with Cystic Fibrosis
Schneider, M., Mühlemann, K., Droz, S., Couzinet, S., Casaulta, C., & Zimmerli, S. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00361-08 · Cited by 84
Bloodstream Infections Caused by Small‐Colony Variants of Coagulase‐Negative Staphylococci Following Pacemaker Implantation
von Eiff, C., Vaudaux, P. E., Kahl, B. C., Lew, D., Emler, S., Schmidt, A., Peters, G., & Proctor, R. A. (1999) · Clinical Infectious Diseases · doi:10.1086/520462 · Cited by 83
Target-Agnostic Identification of Functional Monoclonal Antibodies AgainstKlebsiella pneumoniaeMultimeric MrkA Fimbrial Subunit
Wang, Q., Chang, C.-S., Pennini, M. E., Pelletier, M. R., Rajan, S., Zha, J., Chen, Y., Cvitkovic, R., Sadowska, A., Thompson, J. H., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw021 · Cited by 83
Respiration and Small Colony Variants of Staphylococcus aureus
Proctor, R. A. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0069-2019 · Cited by 82
Relevance of vancomycin-intermediate susceptibility and heteroresistance in methicillin-resistant Staphylococcus aureus bacteraemia
Khatib, R., Jose, J., Musta, A. C., Sharma, M., Fakih, M. G., Johnson, L. B., RIEDERER, K. M., & Shemes, S. P. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr169 · Cited by 81
Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice
Ram, G., Ross, H. F., Novick, R. P., Pagan, I. R., & Jiang, D. (2018) · Nature Biotechnology · doi:10.1038/nbt.4203 · Cited by 81
Novel antibiotics effective against gram-positive and -negative multi-resistant bacteria with limited resistance
Nicolas, I., Bordeau, V., Bondon, A., Baudy-Floc’h, M., & Felden, B. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000337 · Cited by 81
A New Approach for the Discovery of Antibiotics by Targeting Non-Multiplying Bacteria: A Novel Topical Antibiotic for Staphylococcal Infections
Hu, Y., Shamaei‐Tousi, A., Liu, Y., & Coates, A. R. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011818 · Cited by 80
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability
Schilling, N. A., Berscheid, A., Schumacher, J., Saur, J. S., Konnerth, M. C., Wirtz, S. N., Beltrán-Beleña, J. M., Zipperer, A., Krismer, B., Peschel, A., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901589 · Cited by 76
‘Artilysation’ of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci
Rodríguez‐Rubio, L., Chang, W.-L., Gutiérrez, D., Lavigne, R., Martı́nez, B., Rodrı́guez, A., Govers, S. K., Aertsen, A., Hirl, C., Biebl, M., et al. (2016) · Scientific Reports · doi:10.1038/srep35382 · Cited by 73
Aminoglycoside Heteroresistance in Acinetobacter baumannii AB5075
Anderson, S. E., Sherman, E. X., Weiss, D. S., & Rather, P. N. (2018) · mSphere · doi:10.1128/msphere.00271-18 · Cited by 73
Phenotypic variation of Staphylococcus epidermidis in infection of transvenous endocardial pacemaker electrodes
Baddour, L. M., Barker, L. P., Christensen, G. D., Parisi, J. T., & Simpson, W. A. (1990) · Journal of Clinical Microbiology · doi:10.1128/jcm.28.4.676-679.1990 · Cited by 72
The basis of persistent bacterial infections
Rhen, M., Eriksson, S., Clements, M. O., Bergström, S., & Normark, S. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00038-0 · Cited by 69
Fatal Case Due to Methicillin-Resistant Staphylococcus aureus Small Colony Variants in an AIDS Patient
Seifert, H., von Eiff, C., & Fätkenheuer, G. (1999) · Emerging infectious diseases · doi:10.3201/eid0503.990319 · Cited by 68
Persistent Wound Infection after Herniotomy Associated with Small-Colony Variants of Staphylococcus aureus
Abele-Horn, M., Schupfner, B., Emmerling, P., Waldner, H., & Göring, H. (2000) · Infection · doi:10.1007/s150100050014 · Cited by 65
ScanLag: High-throughput Quantification of Colony Growth and Lag Time
Levin-Reisman, I., Fridman, O., & Balaban, N. Q. (2014) · Journal of Visualized Experiments · doi:10.3791/51456 · Cited by 64
CtaA ofStaphylococcus aureusIs Required for Starvation Survival, Recovery, and Cytochrome Biosynthesis
Clements, M. O., Watson, S. P., Poole, R. K., & Foster, S. J. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.2.501-507.1999 · Cited by 64
Efficient microbial colony growth dynamics quantification with ColTapp, an automated image analysis application
Bär, J., Boumasmoud, M., Kouyos, R. D., Zinkernagel, A. S., & Vulin, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-72979-4 · Cited by 62
Self-citation
Antimicrobial resistance three ways: healthcare crisis, major concepts and the relevance of biofilms
Jorge, P., Magalhães, A. P., Grainha, T., Alves, D. F., Sousa, A. M., Lopes, S. P., & Pereira, M. O. (2019) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiz115 · Cited by 59
Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa
Pumbwe, L., & Piddock, L. J. V. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.10.2861-2864.2000 · Cited by 58
Comparison of five methods, including the PDM Epsilometer test (E test), for antimicrobial susceptibility testing of Pseudomonas aeruginosa
Joyce, L., Downes, J., Stockman, K., & Andrew, J. H. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.10.2709-2713.1992 · Cited by 54
Periprosthetic Joint Infections as a Consequence of Bacteremia
Honkanen, M., Jämsen, E., Karppelin, M., Huttunen, R., Eskelinen, A. P., & Syrjänen, J. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz218 · Cited by 53
Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane
Fukuoka, T., Ohya, S., Narita, T., Katsuta, M., Iijima, M., Masuda, N., Yasuda, H., Trias, J., & Nikaido, H. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.2.322 · Cited by 51
Antibiotic Tolerance in Biofilm and Stationary-Phase Planktonic Cells of Staphylococcus aureus
Kamble, E. E., & Pardesi, K. R. (2020) · Microbial Drug Resistance · doi:10.1089/mdr.2019.0425 · Cited by 51
Variables in demonstrating methicillin tolerance in Staphylococcus aureus strains
Ishida, K., Guze, P. A., KALMANSON, G. M., Albrandt, K., & GUZE, L. B. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.4.688 · Cited by 50
Foreign body associated infection
Jansen, B., & Peters, G. (1993) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/32.suppl_a.69 · Cited by 50
Fine-tuning carbapenem resistance by reducing porin permeability of bacteria activated in the selection process of conjugation
Kong, H.-K., Pan, Q., Lo, W.-U., Liu, X., Law, C. O. K., Chan, T., Ho, P., & Lau, T. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-33568-8 · Cited by 49
Studies on Small Colony Variants of Staphylococcus aureus
Swingle, E. L. (1935) · Journal of Bacteriology · doi:10.1128/jb.29.5.467-489.1935 · Cited by 48
Treatment with a Broad-Spectrum Cephalosporin versus Piperacillin-Tazobactam and the Risk for Isolation of Broad-Spectrum Cephalosporin-Resistant Enterobacter Species
Schwaber, M. J., Graham, C. S., Sands, B. E., Gold, H. S., & Carmeli, Y. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.6.1882-1886.2003 · Cited by 48
Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection
Ghosh, C., Manjunath, G. B., Konai, M. M., Uppu, D. S. S. M., Hoque, J., Krishnamoorthy, P., Shome, B. R., & Haldar, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144094 · Cited by 44
Persister Cells and Infectious Disease
(2019) · Springer eBooks · doi:10.1007/978-3-030-25241-0 · Cited by 44
Osteopetrosis, femoral fracture, and chronic osteomyelitis caused by Staphylococcus aureus small colony variants (SCV) treated by girdlestone resection – 6-year follow-up
Rolauffs, B., Bernhardt, T. M., von Eiff, C., Hart, M. L., & Bettin, D. (2002) · Archives of Orthopaedic and Trauma Surgery · doi:10.1007/s00402-002-0435-2 · Cited by 43
Microcolonies (G-variants) of Staphylococcus aureus.
Quie, P. G. (1969) · PubMed Central · Cited by 43
Acquired Resistance to Colistin via Chromosomal And Plasmid-Mediated Mechanisms in Klebsiella pneumoniae
Berglund, B. (2019) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000002 · Cited by 43
Influence of the MBC/MIC ratio on the antibacterial activity of vancomycin versus linezolid against methicillin-resistant Staphylococcus aureus isolates in a pharmacodynamic model simulating serum and soft tissue interstitial fluid concentrations reported in diabetic patients
González, N., Sevillano, D., Alou, L., Cafini, F., Giménez, M.-J., Gómez-Lus, M.-L., Prieto, J., & Aguilar, L. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt185 · Cited by 42
Intrahost Evolution of Methicillin-ResistantStaphylococcus aureusUSA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections
Azarian, T., Daum, R. S., Petty, L. A., Steinbeck, J. L., Yin, Z., Nolan, D. J., Boyle‐Vavra, S., Hanage, W. P., Salemi, M., & David, M. Z. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw242 · Cited by 42
Antimicrobial resistance in clinical isolates of Staphylococcus aureus from hospital and community sources in southern Jamaica
Brown, P. D., & Ngeno, C. (2006) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2006.04.005 · Cited by 40
Recurrent Infections by a Stable Dwarf-colony Variant of Staphylococcus aureus
Goudie, J. G., & Goudie, R. B. (1955) · Journal of Clinical Pathology · doi:10.1136/jcp.8.4.284 · Cited by 38
Species distribution and antifungal susceptibility of bloodstream fungal isolates in paediatric patients in Mexico: a nationwide surveillance study
González, G. M., Treviño‐Rangel, R. D. J., Palma‐Nicolás, J. P., Martinez, C. R., González‐González, J. G., Ayala, J., Caballero, A., Morfín‐Otero, R., Rodríguez-Noriega, E., Velarde, F., et al. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt283 · Cited by 35
Risk factors and treatment outcomes of bloodstream infection caused by extended-spectrum cephalosporin-resistant Enterobacter species in adults with cancer
Huh, K., Kang, C., Kim, J., Cho, S. Y., Ha, Y. E., Joo, E., Chung, D. R., Lee, N. Y., Peck, K. R., & Song, J. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.11.002 · Cited by 34
Pre-Disposition and Epigenetics Govern Variation in Bacterial Survival upon Stress
Ni, M., Decrulle, A. L., Fontaine, F., Démarez, A., Taddéi, F., & Lindner, A. B. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003148 · Cited by 33
Genomic evolution of Staphylococcus aureus isolates colonizing the nares and progressing to bacteremia
Benoit, J. B., Frank, D. N., & Bessesen, M. T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195860 · Cited by 33
Colistin resistance in Enterobacter spp. isolates in Korea
Hong, Y.-K., Lee, J., & Ko, K. S. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-7449-0 · Cited by 30
Genetic and Transcriptomic Analyses of Ciprofloxacin-Tolerant Staphylococcus aureus Isolated by the Replica Plating Tolerance Isolation System (REPTIS)
Matsuo, M., Hiramatsu, M., Singh, M., Sasaki, T., Hishinuma, T., Yamamoto, N., Morimoto, Y., Kirikae, T., & Hiramatsu, K. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02019-18 · Cited by 29
The race between drug introduction and appearance of microbial resistance. Current balance and alternative approaches
López-Jácome, L. E., Franco‐Cendejas, R., Quezada, H., Morales-Espinosa, R., Castillo‐Juárez, I., González‐Pedrajo, B., Fernández-Presas, A. M., Tovar-García, A., Angarita-Zapata, V., Licona-Limón, P., et al. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.04.016 · Cited by 28
FDA approves antitoxin antibody
Mullard, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.257 · Cited by 21
Molecular Epidemiology of Invasive Staphylococcus aureus Infections and Concordance with Colonization Isolates
Thomsen, I. P., Kadari, P., Soper, N. R., Riddell, S. W., Kiska, D. L., Creech, C. B., & Shaw, J. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.03.004 · Cited by 21
The Architecture of a Prototypical Bacterial Signaling Circuit Enables a Single Point Mutation to Confer Novel Network Properties
Ram, S., & Goulian, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003706 · Cited by 16
Colistin resistance in Pseudomonas aeruginosa and Achromobacter spp. cultured from Danish cystic fibrosis patients is not related to plasmid-mediated expression of mcr-1
Pedersen, M. G., Olesen, H. V., Jensen‐Fangel, S., Nørskov‐Lauritsen, N., & Wang, M. (2017) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2017.12.001 · Cited by 16
ScanLag: High-throughput Quantification of Colony Growth and Lag Time
Levin-Reisman, I., Fridman, O., & Balaban, N. Q. (2014) · Journal of Visualized Experiments · doi:10.3791/51456-v · Cited by 16
Small Colony variants of Staphylococcus aureus isolated from a patient with infective endocarditis: a case report and review of the literature.
Bhattacharyya, S., Roy, S., Mukhopadhyay, P., Rit, K., Dey, J. B., Ganguly, U., & Ray, R. (2012) · Europe PMC (PubMed Central) · Cited by 13
Bacterial colonization of handheld devices in a tertiary care setting: a hygiene intervention study
Frey, P. M., Marti, G., Droz, S., von Arx, M. D. R., Suter‐Riniker, F., Aujesky, D., & Brugger, S. D. (2019) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-019-0546-y · Cited by 13
Self-citation
Persister Formation and Antibiotic Tolerance of Chronic Infections
Lewis, K., & Manuse, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-25241-0_4 · Cited by 12
EMA opens its data vaults
Mullard, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.259 · Cited by 9
Mechanisms of resistance to beta-lactam antibiotics in Staphylococcus aureus.
LACEY, R. W. (1984) · PubMed · Cited by 7

Research works printed but not linked: 3

CDC (2019). Antibiotic resistance threats in the united states, 2019, in: Atlanta G.U.S.D.o.H.a.H.S. (Ed.). CDC.
ECDC (2019) Surveillance of antimicrobial resistance in Europe 2018, Stockholm: European Centre for Disease Prevention and Control
Fleming A (1929) On antibacterial action of culture of Penicillium, with special reference to their use in isolation of B. influenzae. Br J Exp Pathol 10: 226–236

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Authors: Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S.
Affiliations: University of Zurich (CH)
ORCID: Huemer, Markus
Mairpady Shambat, Srikanth
Brugger, Silvio D
Zinkernagel, Annelies S
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2020-12-03
Volume: 21
Issue: 12
Pages: e51034-e51034
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.15252/embr.202051034
PMC: PMC7726816
OpenAlex: W3112882148
Cited by: 850
References: 276
Citations by year: 2026: 155 · 2025: 253 · 2024: 234 · 2023: 129 · 2022: 67 · 2021: 11 · 2020: 1
FWCI: 7.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Svenska Sällskapet för Medicinsk Forskning (P17‐0179)
Promedica Stiftung (1449/M)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: antibiotic persistence, antibiotic resistance, bacterial persistence, bacterial heterogeneity, antibiotic tolerance, antibiotic resistance evolution, treatment failure, infection relapse, human health, new antibiotic development
MeSH terms: Anti-Bacterial Agents, Bacteria, Drug Resistance, Microbial, Humans, Drug Resistance, Bacterial

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Antibiotic resistance and persistence—Implications for human health and treatment perspectives

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