Cited by 856Bacterial Genetics and BiotechnologyAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in Bacteria

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Antibiotic resistance and persistence—Implications for human health and treatment perspectives

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Huemer, Markus, Mairpady Shambat, Srikanth, Brugger, Silvio D, Zinkernagel, Annelies S·2020·The EMBO Reports

DOI 10.15252/embr.202051034PMC PMC7726816

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Abstract

Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of treatment failure and relapsing infections. They are thus important drivers of increased morbidity and mortality rates resulting in growing healthcare costs. Antibiotic resistance is readily identifiable with standard microbiological assays, and the threat imposed by antibiotic resistance has been well recognized. Measures aiming to reduce resistance development and spreading of resistant bacteria are being enforced. However, the phenomenon of bacteria surviving antibiotic exposure despite being fully susceptible, so-called antibiotic persistence, is still largely underestimated. In contrast to antibiotic resistance, antibiotic persistence is difficult to measure and therefore often missed, potentially leading to treatment failures. In this review, we focus on bacterial mechanisms allowing evasion of antibiotic killing and discuss their implications on human health. We describe the relationship between antibiotic persistence and bacterial heterogeneity and discuss recent studies that link bacterial persistence and tolerance with the evolution of antibiotic resistance. Finally, we review persister detection methods, novel strategies aiming at eradicating bacterial persisters and the latest advances in the development of new antibiotics.

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Antibiotic Susceptibility Testing by a Standardized Single Disk Method
Bauer, A. W., Kirby, W. M. M., Sherris, J. C., & Turck, M. (1966) · American Journal of Clinical Pathology · doi:10.1093/ajcp/45.4_ts.493 · Cited by 18,523
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30753-3 · Cited by 6,142
Staphylococcus aureus Infections
Lowy, F. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808203390806 · Cited by 6,018
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Boucher, H. W., Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Rice, L. B., Scheld, M., Spellberg, B. J., & Bartlett, J. (2008) · Clinical Infectious Diseases · doi:10.1086/595011 · Cited by 5,092
The antibiotic resistance crisis: part 1: causes and threats.
Ventola, C. L. (2015) · PubMed Central · Cited by 4,558
Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children
Liu, C., Bayer, A. S., Cosgrove, S. E., Daum, R. S., Fridkin, S. K., Gorwitz, R. J., Kaplan, S. L., Karchmer, A. W., Levine, D. P., Murray, B. E., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq146 · Cited by 4,260
Molecular mechanisms of antibiotic resistance
Blair, J. M. A., Webber, M. A., Baylay, A. J., Ogbolu, D. O., & Piddock, L. J. V. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3380 · Cited by 4,092
Update on Key Emerging Challenges in Cystic Fibrosis
Jennings, M. T., Riekert, K. A., & Boyle, M. (2014) · Medical Principles and Practice · doi:10.1159/000357646 · Cited by 3,671
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952

Show all 276 references

Research works printed but not linked: 3

CDC (2019). Antibiotic resistance threats in the united states, 2019, in: Atlanta G.U.S.D.o.H.a.H.S. (Ed.). CDC.
ECDC (2019) Surveillance of antimicrobial resistance in Europe 2018, Stockholm: European Centre for Disease Prevention and Control
Fleming A (1929) On antibacterial action of culture of Penicillium, with special reference to their use in isolation of B. influenzae. Br J Exp Pathol 10: 226–236

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Self-citation

Authors: Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S.
Affiliations: University of Zurich (CH)
ORCID: Huemer, Markus
Mairpady Shambat, Srikanth
Brugger, Silvio D
Zinkernagel, Annelies S
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2020-12-03
Volume: 21
Issue: 12
Pages: e51034-e51034
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.15252/embr.202051034
PMC: PMC7726816
OpenAlex: W3112882148
Cited by: 850
References: 276
Citations by year: 2026: 155 · 2025: 253 · 2024: 234 · 2023: 129 · 2022: 67 · 2021: 11 · 2020: 1
FWCI: 7.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Svenska Sällskapet för Medicinsk Forskning (P17‐0179)
Promedica Stiftung (1449/M)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: antibiotic persistence, antibiotic resistance, bacterial persistence, bacterial heterogeneity, antibiotic tolerance, antibiotic resistance evolution, treatment failure, infection relapse, human health, new antibiotic development
MeSH terms: Anti-Bacterial Agents, Bacteria, Drug Resistance, Microbial, Humans, Drug Resistance, Bacterial

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Antibiotic resistance and persistence—Implications for human health and treatment perspectives

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