High‐throughput Discovery of Functional Disordered Regions
Open accessAbstract
Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered regions. In their recent work, Babu and colleagues (Ravarani et al , 2018) took on this challenge by developing IDR‐Screen, a robust high‐throughput approach for identifying functions of disordered regions.
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The lack of readily druggable pockets for most transcription factors is a challenge for targeting them therapeutically.
“These include the inherent complexity of their protein‒protein interactions [15] and the lack of readily druggable pockets for most transcription factors [16].”
From Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease (2026) · cites this paper as [16]
The discussion of transactivation domains in the paper’s Abstract describes disordered regions and their binding to coactivators, but does not address whether most transcription factors lack druggable pockets or whether that limits therapeutic targeting. Searches for druggable pockets and therapeutic targeting found no passage addressing that claim (page not available in our copy). (LLM, conf=0.72)
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Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158 · see citing works
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Research works printed but not linked: 9
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Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease
Kim, B., Wang, S. S., Kim, J. R., & Kim, J. (2026) · BioEssays · doi:10.1002/bies.70186
- Authors
- Ali, M., & Ivarsson, Y.
- Affiliations
- Uppsala University (SE)
- Venue
- Molecular Systems Biology
- Published
- 2018-05-01
- Volume
- 14
- Issue
- 5
- Pages
- e8377-e8377
- ISSN
- 1744-4292 (ISSN-L)
- PMC
- PMC5974509
- OpenAlex
- W2803402887
- Cited by
- 4
- References
- 1
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Systems Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- intrinsically disordered regions, disordered proteins, high-throughput functional screening, eukaryotic proteomes
- MeSH terms
- Amino Acid Sequence, Protein Conformation, Proteins, Databases, Protein
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