The DOI matches its Crossref record; 84 of the 85 references it cites were found in a registry or an index, and 1 are not checked yet.
Hematopoietic Stem Cells and Their Roles in Tissue Regeneration
Open accessAbstract
Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is unarguably regarded as an important cell source in stem cell biology. So far, many investigators are exploring HSCs and modified HSCs for use in clinical and basic science. In the present review, we briefly summarized HSCs and their application in pathophysiologic conditions, including non-hematopoietic tissue regeneration as well as blood disorders. HSCs and HSCs-derived progenitors are promising cell sources in regenerative medicine and their contributions can be properly applied to treat pathophysiologic conditions. Among many adult stem cells, HSCs are a powerful tool to treat patients with diseases such as hematologic malignancies and liver disease. Since HSCs can be differentiated into diverse progenitors including endothelial progenitors, they may be useful for constructing strategies for effective therapy.
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“In myelosuppressive conditions induced by the administration of granulocyte colony-stimulating factor (G-CSF), they proliferate, mobilize, and emigrate rapidly from the BM into PB, thereby enabling their purification from harvested PB-MNCs based on their positive expression of the cluster of differentiation 34 (CD34) and CD133 surface markers [54, 55].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [55]
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Health Effects of Ionizing Radiation on the Human Body
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Metadata
- Authors
- Lee, J. Y., & Hong, S.-H.
- Affiliations
- CHA University (KR)
- Kangwon National University (KR)
- Corresponding author
- Hong, Seok-Ho
- Venue
- International Journal of Stem Cells
- Published
- 2020-03-30
- Volume
- 13
- Issue
- 1
- Pages
- 1-12
- ISSN
- 2005-3606 (ISSN-L)
- 2005-5447
- PMC
- PMC7119209
- OpenAlex
- W2997983238
- Cited by
- 165
- References
- 84
- Citations by year
- 2026: 26 · 2025: 42 · 2024: 44 · 2023: 31 · 2022: 11 · 2021: 8 · 2020: 3
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- International Journal of Stem Cells (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- hematopoietic stem cells, tissue regeneration, regenerative medicine, hematologic disorders, hematologic malignancies, liver disease, endothelial progenitor cells, stem cell therapy
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