Cited by 165Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchPluripotent Stem Cells Research

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Hematopoietic Stem Cells and Their Roles in Tissue Regeneration

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Lee, Ji Yoon, Hong, Seok-Ho·2020·International Journal of Stem Cells

DOI 10.15283/ijsc19127PMC PMC7119209

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Abstract

Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is unarguably regarded as an important cell source in stem cell biology. So far, many investigators are exploring HSCs and modified HSCs for use in clinical and basic science. In the present review, we briefly summarized HSCs and their application in pathophysiologic conditions, including non-hematopoietic tissue regeneration as well as blood disorders. HSCs and HSCs-derived progenitors are promising cell sources in regenerative medicine and their contributions can be properly applied to treat pathophysiologic conditions. Among many adult stem cells, HSCs are a powerful tool to treat patients with diseases such as hematologic malignancies and liver disease. Since HSCs can be differentiated into diverse progenitors including endothelial progenitors, they may be useful for constructing strategies for effective therapy.

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Authors: Lee, J. Y., & Hong, S.-H.
Affiliations: CHA University (KR)
Kangwon National University (KR)
Corresponding author: Hong, Seok-Ho
ORCID: Lee, Ji Yoon
Hong, Seok-Ho
Venue: International Journal of Stem Cells
Publisher: Korean Society for Stem Cell Research
Published: 2020-03-30
Volume: 13
Issue: 1
Pages: 1-12
ISSN: 2005-3606 (ISSN-L)
2005-5447
DOI: 10.15283/ijsc19127
PMC: PMC7119209
OpenAlex: W2997983238
Cited by: 165
References: 84
Citations by year: 2026: 26 · 2025: 42 · 2024: 44 · 2023: 31 · 2022: 11 · 2021: 8 · 2020: 3
FWCI: 3.89
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (tdm)
Locations: International Journal of Stem Cells (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: hematopoietic stem cells, tissue regeneration, regenerative medicine, hematologic disorders, hematologic malignancies, liver disease, endothelial progenitor cells, stem cell therapy

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Hematopoietic Stem Cells and Their Roles in Tissue Regeneration

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