The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Abstract
Objective: Lifelong glucocorticoid therapy in patients with congenital adrenal hyperplasia (CAH) or the disease per se may result in increased cardiovascular risk. We therefore investigated cardiovascular and metabolic risk profiles in adult CAH males. Subjects and methods: We compared CAH males ( n =30), 19–67 years old, with age- and sex-matched controls ( n =32). Subgroups of different ages (<30 years or older) and CYP21A2 genotypes (null, I2splice, and I172N as the mildest mutation) were studied. Anthropometry, fat and lean mass measured by dual-energy X-ray absorptiometry, lipids, liver function tests, homocysteine, lipoprotein-(a), glucose and insulin during an oral glucose tolerance test (OGTT), urine albumin, adrenal hormones, and 24 h ambulatory blood pressure measurements were studied. Results: CAH males were shorter. Waist/hip ratio and fat mass were higher in older patients and the I172N group. Heart rate was faster in older patients, the I2splice, and I172N groups. Insulin levels were increased during OGTT in all patients and in the I172N group. γ-glutamyl transpeptidase was increased in older patients and in the I172N group. Testosterone was lower in older patients. Homocysteine was lower in younger patients, which may be cardioprotective. The cardiovascular risk seemed higher with hydrocortisone/cortisone acetate than prednisolone. Urinary epinephrine was lower in all groups of patients except in I172N. Conclusions: Indications of increased risk were found in CAH males ≥30 years old and in the I172N group. In contrast, younger CAH males did not differ from age-matched controls. This is likely to reflect a better management in recent years.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased abdominal adiposity, with a higher proportion of pro-inflammatory visceral adipose tissue compared to subcutaneous adipose tissue, was present in adolescents and young adults with CAH compared to age-, sex-and BMI-matched controls (673).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [673]
Citations
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Heart rate and cardiovascular mortality: The Framingham study
Kannel, W. B., Kannel, C., Paffenbarger, R. S., & Cupples, L. A. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90666-1 · Cited by 1,292
γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality
Ruttmann, E., Brant, L. J., Concin, H., Diem, G., Rapp, K., Ulmer, H., & the Vorarlberg Health Monitoring and Promotion Program Study Group (2005) · Circulation · doi:10.1161/circulationaha.105.552547 · Cited by 553
Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients
Arlt, W., Willis, D. S., Wild, S. H., Krone, N., Doherty, E. J., Hahner, S., Han, T. S., Carroll, P. V., Conway, G. S., Rees, D. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0917 · Cited by 506
Wedell, A. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.5.1145 · Cited by 370
Self-citationFrisén, L., Nordenström, A., Falhammar, H., Filipsson, H., Holmdahl, G., Janson, P. O., Thorén, M., Hagenfeldt, K., Möller, A., & Nordenskjöld, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0636 · Cited by 276
Self-citationHagenfeldt, K., Janson, P. O., Holmdahl, G., Falhammar, H., Filipsson, H., Frisen, L., Thoren, M., & Nordenskjold, A. (2008) · Human Reproduction · doi:10.1093/humrep/den118 · Cited by 205
Self-citationNordenskjöld, A., Holmdahl, G., Frisén, L., Falhammar, H., Filipsson, H., Thorén, M., Janson, P. O., & Hagenfeldt, K. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0556 · Cited by 205
Self-citationThe relationship between resting heart rate and all-cause, cardiovascular and cancer mortality
Mensink, G., & Hoffmeister, H. M. (1997) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015465 · Cited by 179
Falhammar, H., Filipsson, H., Holmdahl, G., Janson, P.-O., Nordenskjöld, A., Hagenfeldt, K., & Thorén, M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1350 · Cited by 167
Self-citation
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–103 of 103
Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management
Mu, J., Li, Y. J., Sun, M., Li, Y. J., Li, P., & Zou, H. (2026) · Clinical Endocrinology · doi:10.1111/cen.70155
Kim, H., Lin, V. H., Newfield, R. S., Dauber, A., Luo, M., Cicero, S., Li, M., Zhao, C., & Cheng, H. K.-H. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag112
Real-world outcomes with modified-release hydrocortisone in classic congenital adrenal hyperplasia
Auer, M. K., Bayer, K., Nowotny, H. F., Tschaidse, L., Dervishi, O., Welp, A.-C., Lottspeich, C., Bidlingmaier, M., Kunz, S. L., & Reisch, N. (2026) · European Journal of Endocrinology · doi:10.1093/ejendo/lvag087
Metadata
- Authors
- Falhammar, H., Filipsson Nyström, H., Wedell, A., & Thorén, M.
- Affiliations
- Karolinska University Hospital (SE)
- ORCID
- Falhammar, Henrik
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02
- Volume
- 164
- Issue
- 2
- Pages
- 285-293
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2131502301
- Cited by
- 103
- References
- 35
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 10
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, cardiovascular risk, metabolic profile, body composition, CYP21A2 mutations, glucocorticoid therapy, cortisol, prednisolone, insulin resistance, homocysteine, lipoprotein(a), ambulatory blood pressure, testosterone, urinary epinephrine, adult male
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adult, Aged, Blood Glucose, Body Composition, Body Height, Cardiovascular Diseases, Genotype, Humans, Lipids, Male, Middle Aged, Renin, Risk, Steroid 21-Hydroxylase, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
