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Cited by 402Pituitary Gland Disorders and TreatmentsAdrenal and Paraganglionic TumorsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

The European Registry on Cushing’s syndrome: 2-year experience. Baseline demographic and clinical characteristics

Valassi, Elena, Santos, Alicia, Yaneva, Maria, Tóth, Miklós, Strasburger, Christian J, Chanson, Philippe, Wass, John A H, Chabre, Olivier, Pfeifer, Marija, Feelders, Richard A, Tsagarakis, Stylianos, Trainer, Peter J, Franz, Holger, Zopf, Kathrin, Zacharieva, Sabina, Lamberts, Steven W J, Tabarin, Antoine, Webb, Susan M·2011·European Journal of Endocrinology
DOI 10.1530/eje-11-0272
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Abstract

Objective: The European Registry on Cushing's syndrome (ERCUSYN) is designed to collect prospective and follow-up data at EU level on Cushing's syndrome (CS). Design and methods: Baseline data on 481 CS patients (390 females, 91 males; mean age (± s.d. ): 44±14 years) collected from 36 centres in 23 countries, including new patients from 2008 and retrospective cases since 2000. Patients were divided into four major aetiologic groups: pituitary-dependent CS (PIT-CS) (66%), adrenal-dependent CS (ADR-CS) (27%), CS from an ectopic source (ECT-CS) (5%) and CS from other aetiologies (2%). Results: Proportion of men in the ECT-CS group was higher than in the other groups ( P <0.05). The ADR-CS group was older than the PIT-CS ( P <0.05). Prevalence of hirsutism (92%) and diabetes (74%) in ECT-CS was higher than in the other groups ( P <0.05 and P <0.01 respectively). PIT-CS had more skin alterations, menstrual irregularities and hirsutism than ADR-CS ( P <0.01). Reduced libido was more prevalent in men than women ( P <0.01). Prevalence of spine osteoporosis was higher in men than women ( P <0.05), and males had more vertebral and rib fractures than females (52 vs 18% for vertebrae; P <0.001 and 34 vs 23% for ribs; P <0.05). ECT-CS consulted a diabetologist more frequently than ADR-CS ( P <0.05), while a gynaecologist was consulted more often by women with PIT-CS or ADR-CS than with ECT-CS ( P <0.05). Overall, weight gain was more common in women than men ( P <0.01). CushingQoL and EuroQoL visual analogue scale scores did not differ between the groups. Conclusions: The ERCUSYN project demonstrates a heterogeneous clinical presentation of CS at a European level, depending on gender and aetiology.

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  2. 2000, Medical care, 47, 255

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Metadata

Authors
Valassi, E., Santos, A., Yaneva, M., Tóth, M., Strasburger, C. J., Chanson, P., Wass, J. A. H., Chabre, O., Pfeifer, M., Feelders, R. A., Tsagarakis, S., Trainer, P. J., Franz, H., Zopf, K., Zacharieva, S., Lamberts, S. W. J., Tabarin, A., & Webb, S. M.
Affiliations
  • Universitat Autònoma de Barcelona (ES)
  • Medical University of Sofia (BG)
  • Semmelweis University (HU)
  • Charité – Universitätsmedizin Berlin (DE)
  • Université Paris-Sud (FR)
  • Churchill Hospital (GB)
  • Ljubljana University Medical Centre (SI)
  • Erasmus MC (NL)
  • Polyclinic General Hospital (GR)
  • The Christie Hospital (GB)
  • Centre Hospitalier Universitaire de Bordeaux (FR)
Corresponding author
Valassi, Elena
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2011-09
Volume
165
Issue
3
Pages
383-392
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-11-0272
OpenAlex
W2171877884
Semantic Scholar
3321b1ce595761b981c3e19ea91e6efc18a85c8e
Cited by
402
References
36
Citations by year
2026: 28 · 2025: 25 · 2024: 27 · 2023: 29 · 2022: 44 · 2021: 31 · 2020: 27 · 2019: 24 · 2018: 35 · 2017: 20 · 2016: 23 · 2015: 38 · 2014: 19 · 2013: 15 · 2012: 15
FWCI
12.86
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Funders
European Commission
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
Cushing's syndrome, pituitary-dependent Cushing's disease, ectopic ACTH syndrome, clinical features, sex differences, hirsutism, diabetes mellitus, osteoporosis, quality of life, EuroQol, patient registry
MeSH terms
Adolescent, Adrenal Gland Neoplasms, Adult, Aged, Aged, 80 and over, Bone Diseases, Metabolic, Cushing Syndrome, Europe, Female, Humans, Male, Middle Aged, Pituitary Neoplasms, Prospective Studies, Quality of Life, Registries, Retrospective Studies, Cohort Studies, Prevalence, Fractures, Bone

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