Long-term DHEA substitution in female adrenocortical failure, body composition, muscle function, and bone metabolism: a randomized trial
Abstract
Context Adrenal derived androgens are low in women with adrenal failure. The physiological consequences of substitution therapy are uncertain. Objective To investigate the effects of DHEA substitution in women with adrenal failure on body composition, fuel metabolism, and inflammatory markers. DESIGN, PARTICIPANTS AND INTERVENTION: In this study, ten female patients (median age 38.5 years, range 28-52) with adrenal failure were treated with DHEA 50 mg for 6 months in a double-blind, randomized, placebo-controlled, and crossover study. The participants underwent dual-energy X-ray absorptiometry (DXA) scan, computed tomography scan of abdominal fat, indirect calorimetry, bicycle ergometry, muscle and fat biopsies, and blood samples. Results Baseline androgens were normalized to fertile range during active treatment. Anthropometric data were unaffected, but lean body mass (LBM) slightly increased compared with placebo (delta LBM (kg) placebo versus DHEA: -0.48±6.1 vs 1.6±3.4, P=0.02) with no alterations in total or abdominal fat mass. PTH increased with DHEA, but no significant changes were observed in other bone markers or in bone mineral content. The mRNA levels of markers of tissue inflammation (adiponectin, interleukin 6 (IL6), IL10, monocyte chemoattractant protein 1, and tumor necrosis factor α) in fat and muscle tissue were unaffected by DHEA treatment, as was indirect calorimetry and maximal oxygen uptake. A high proportion of self-reported seborrheic side effects were r…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some but not all studies have shown that DHEA replacement in adrenal insufficiency may improve HRQoL and mood, with reduced depression and anxiety scores.
“In addition, some (but not all) studies have shown that DHEA replacement in adrenal insufficiency may improve HRQoL and mood, with reduced depression and anxiety scores (114 -116).”
From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [116]
Cites
Calculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365 · see citing works
Katznelson, L., Finkelstein, J. S., Schoenfeld, D. A., Rosenthal, D. I., Anderson, E. J., & Klibanski, A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954042 · Cited by 791 · see citing works
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685 · see citing works
Hanson, D. A., Weis, M. A., Bollen, A., Maslan, S., Singer, F. R., & Eyre, D. W. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650071119 · Cited by 653 · see citing works
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644 · see citing works
Risteli, J., Elomaa, I., Niemi, S., Novamo, A., & Risteli, L. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.4.635 · Cited by 621 · see citing works
Osteoporosis in Men with Idiopathic Hypogonadotropic Hypogonadism
Finkelstein, J. S., KLIBANSKI, A., NEER, R. M., GREENSPAN, S. L., ROSENTHAL, D. I., & CROWLEY, W. F. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-3- · Cited by 407 · see citing works
Hunt, P. J., Gurnell, E. M., Huppert, F. A., Richards, C., Prevost, A. T., Wass, J. A. H., Herbert, J., & Chatterjee, V. K. K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7022 · Cited by 386 · see citing works
Effects of Androgen on Sexual Behavior in Hypogonadal Men
Davidson, J. M., Camargo, C. A., & Smith, E. R. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-6-955 · Cited by 367 · see citing works
Immunoassay for intact amino-terminal propeptide of human type I procollagen
Melkko, J., Kauppila, S., Niemi, S., Risteli, L., Haukipuro, K. A., Jukkola, A., & Risteli, J. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.6.947 · Cited by 283 · see citing works
Frystyk, J., Dinesen, B., & Ørskov, H. (1995) · PubMed · Cited by 272 · see citing works
Lovejoy, J. C., Bray, G. A., Bourgeois, M., Macchiavelli, R. E., Rood, J. C., Greeson, C., & Partington, C. (1996) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.81.6.8964851 · Cited by 235 · see citing works
The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
Webb, S. J., Geoghegan, T. E., Prough, R. A., & Miller, K. K. M. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600569877 · Cited by 235 · see citing works
Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial
Gurnell, E. M., Hunt, P. J., Curran, S. E., Conway, C. L., Pullenayegum, E. M., Huppert, F. A., Compston, J. E., Herbert, J., & Chatterjee, V. K. K. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1134 · Cited by 189 · see citing works
Johannsson, G., Burman, P., Wirén, L., Engström, B. E., Nilsson, A. G., Ottosson, M., Jonsson, B., Bengtsson, B.-Å., & Karlsson, F. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8494 · Cited by 175 · see citing works
Løvås, K., Gebre-Medhin, G., Trovik, T. S., Fougner, K. J., Uhlving, S., Nedrebø, B. G., Myking, O. L., Kämpe, O., & Husebye, E. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020769 · Cited by 144 · see citing works
Panhypopituitarism as a Model to Study the Metabolism of Dehydroepiandrosterone (DHEA) in Humans
Young, J., Couzinet, B., NAHOUL, K., Brailly, S., Chanson, P., Baulieu, E. E., & SCHAISON, G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4157 · Cited by 133 · see citing works
Rosalki, S. B., Foo, A. Y., Burlina, A., Prellwitz, W., Stieber, P., Neumeier, D., Klein, G., Poppe, W., & Bodenmüller, H. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.4.648 · Cited by 130 · see citing works
Androgens and the control of skeletal muscle protein synthesis
Sheffield‐Moore, M. (2000) · Annals of Medicine · doi:10.3109/07853890008998825 · Cited by 123 · see citing works
Androgen Deficiency in Women with Hypopituitarism1
Miller, K. K., Sesmilo, G., Schiller, A., Schoenfeld, D., Burton, S., & Klibanski, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7246 · Cited by 117 · see citing works
Effect of Dehydroepiandrosterone Replacement on Insulin Sensitivity and Lipids in Hypoadrenal Women
Dhatariya, K., Bigelow, M. L., & Nair, K. S. (2005) · Diabetes · doi:10.2337/diabetes.54.3.765 · Cited by 113 · see citing works
Lykkesfeldt, G., BENNETT, P., Lykkesfeldt, A. E., Mičić, S., MØLLER, S., & Svenstrup, B. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb01096.x · Cited by 105 · see citing works
Callies, F., Faßnacht, M., van Vlijmen, J. C., Koehler, I., Huebler, D., Seibel, M. J., Arlt, W., & Allolio, B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7483 · Cited by 97 · see citing works
BARTSCH, W. (1980) · Maturitas · doi:10.1016/0378-5122(80)90044-4 · Cited by 96 · see citing works
Androgen Deficiency in Women with Hypopituitarism
Miller, K. K. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.561 · Cited by 83 · see citing works
van Thiel, S. W., Romijn, J. A., Pereira, A. M., Biermasz, N. R., Roelfsema, F., van Hemert, A., Ballieux, B., & Smit, J. W. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1802 · Cited by 66 · see citing works
Brooke, A., Kalingag, L. A., Miraki-Moud, F., Camacho-Hübner, C., Maher, K., Walker, D., Hinson, J., & Monson, J. (2006) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2006-0316 · Cited by 61 · see citing works
Gravholt, C. H., Næraa, R. W., Brixen, K., Kastrup, K. W., Mosekilde, L., Jørgensen, J. O. L., & Christiansen, J. S. (2002) · PEDIATRICS · doi:10.1542/peds.110.5.889 · Cited by 61 · see citing works
Self-citationRisteli, J., SØGAARD, H., Oikarinen, A., Risteli, L., KARVONEN, J., & ZACHARIAE, H. (1988) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1988.tb03224.x · Cited by 39 · see citing works
Weeke, J., Boye, N., & Ørskov, H. (1986) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518609083686 · Cited by 32 · see citing works
Christiansen, J., Gravholt, C., Fisker, S., Møller, N., Andersen, M., Svenstrup, B., Bennett, P., Ivarsen, P., Christiansen, J., & Jørgensen, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01810 · Cited by 31 · see citing works
Self-citationChristiansen, J., Andersen, N. H., Sørensen, K., Pedersen, E. M., Bennett, P., Andersen, M., Christiansen, J., Jørgensen, J. O., & Gravholt, C. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02750.x · Cited by 30 · see citing works
Self-citation[Thyrotropin releasing hormone and serum levels of catecholamines as well as 11-hydroxycorticoids].
Brisse, B., Wagner, H., Vosberg, H., Hurbesch, M., Böckel, K., & Hauss, W. H. (1971) · PubMed · Cited by 25 · see citing works
Sun, H., Zang, W., Zhou, B., Xu, L., & Wu, S. (2011) · Endocrinology · doi:10.1210/en.2010-0920 · Cited by 20 · see citing works
Christiansen, J. J., Fisker, S., Gravholt, C. H., Bennett, P., Svenstrup, B., Andersen, M., Feldt-Rasmussen, U., Christiansen, J. S., & Jørgensen, J. O. L. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01898 · Cited by 16 · see citing works
Self-citationChristiansen, J. J., Gravholt, C. H., Fisker, S., Svenstrup, B., Bennett, P., Veldhuis, J., Andersen, M., Christiansen, J. S., & Jørgensen, J. O. L. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01998.x · Cited by 12 · see citing works
Self-citationBurt, M. G., Johannsson, G., Umpleby, A. M., Chisholm, D. J., & Ho, K. K. Y. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2333 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Bornstein, S. R., Allolio, B., Arlt, W., Barthel, A., Don-Wauchope, A., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Stratakis, C. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1710 · Cited by 1,769 · see citing works
“In addition, some (but not all) studies have shown that DHEA replacement in adrenal insufficiency may improve HRQoL and mood, with reduced depression and anxiety scores (114–116).”
BackgroundHusebye, E. S., Pearce, S. H., Krone, N. P., & Kämpe, O. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00136-7 · Cited by 378 · see citing works
Androgen therapy in women: a reappraisal: an Endocrine Society Clinical Practice Guideline
Wierman, M. E., Arlt, W., Basson, R., Davis, S. R., Miller, K. K., Murad, M. H., Rosner, W., & Santoro, N. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2260 · Cited by 363 · see citing works
Dehydroepiandrosterone (DHEA): Hypes and Hopes
Rutkowski, K., Sowa, P., Rutkowska-Talipska, J., Kuryliszyn-Moskal, A., & Rutkowski, R. (2014) · Drugs · doi:10.1007/s40265-014-0259-8 · Cited by 216 · see citing works
Methlie, P., Hustad, S., Kellman, R., Almås, B., Erichsen, M. M., Husebye, E. S., & Løvås, K. (2013) · Endocrine Connections · doi:10.1530/ec-13-0023 · Cited by 92 · see citing works
Glintborg, D., Christensen, L. L., Kvorning, T., Larsen, R., Brixen, K., HOUGAARD, D. M., Richelsen, B., Bruun, J. M., & Andersen, M. (2013) · Mediators of Inflammation · doi:10.1155/2013/539156 · Cited by 19 · see citing works
Self-citationFunctions of dehydroepiandrosterone in relation to breast cancer
Chatterton, R. T. (2022) · Steroids · doi:10.1016/j.steroids.2022.108970 · Cited by 17 · see citing works
Guidelines for diagnosis and treatment of adrenal insufficiency in adults
Novoa, P. D. M., Vela, E. T., García, N. P., Rodríguez, M. M., Guerras, I. S., Santamaría, M. D. L. Á. M. D. S., & Aulinas, A. (2014) · Endocrinología y Nutrición (English Edition) · doi:10.1016/s2173-5093(14)70069-8 · Cited by 14 · see citing works
Phase II Study of Dehydroepiandrosterone in Androgen Receptor-Positive Metastatic Breast Cancer
Pietri, E., Massa, I., Bravaccini, S., Ravaioli, S., Tumedei, M. M., Petracci, E., Donati, C., Schirone, A., Piacentini, F., Gianni, L., et al. (2018) · The Oncologist · doi:10.1634/theoncologist.2018-0243 · Cited by 14 · see citing works
Zhu, Y., Qiu, L., Jiang, F., Găman, M., Abudoraehem, O., Okunade, K. S., & Zhang, M. (2021) · Steroids · doi:10.1016/j.steroids.2021.108889 · Cited by 14 · see citing works
Wang, X., Feng, H., Fan, D.-H., Zou, G., Han, Y., & Liu, L. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102583 · Cited by 12 · see citing works
Li, Y., Ren, J., Li, N., Liu, J., Tan, S. C., Low, T. Y., & Ma, Z.-M. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111110 · Cited by 12 · see citing works
Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines
Fichna, M., Fichna, P., Gryczyńska, M., Czarnywojtek, A., Żurawek, M., & Ruchała, M. (2014) · Endocrine · doi:10.1007/s12020-014-0388-6 · Cited by 11 · see citing works
The role for long-term use of dehydroepiandrosterone in adrenal insufficiency
Bennett, G., Cussen, L., & O’Reilly, M. (2022) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000728 · Cited by 8 · see citing works
Hu, C., Zhao, J., Sun, C., Santos, H. O., & Kord‐Varkaneh, H. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14698 · Cited by 5 · see citing works
Neuroendocrine and inflammatory responses to DHEA administration in young healthy women
Collomp, K., Gravisse, N., Vibarel-Rebot, N., Asselin, M., Do, M. C., Gagey, O., Letiec, C., Dufaÿ, S., Buisson, C., & Audran, M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.09.001 · Cited by 4 · see citing works
Androgen deficiency in women with adrenal insufficiency. Dehydroepiandrosterone. Review
Nuralieva, N., Yukina, M., Troshina, E., & Platonova, N. (2018) · Gynecology · doi:10.26442/2079-5696_2018.4.35-39 · Cited by 1 · see citing works
The Future of Drugs in Sarcopenia
Zazzara, M. B., Penfold, R., & Onder, G. (2021) · Practical issues in geriatrics · doi:10.1007/978-3-030-80038-3_14 · Cited by 2 · see citing works
Landi, F., Onder, G., & Rolland, Y. (2012) · doi:10.1002/9781118338032.ch20 · Cited by 2 · see citing works
Yukina, M., Chernova, M. O., Nuralieva, N., Eremkina, A., Troshina, E., Melnichenko, G. A., & Mokrysheva, N. (2020) · Obesity and Metabolism · doi:10.14341/omet12700 · Cited by 1 · see citing works
Dehydroepiandrosterone (DHEA) in relation to breast cancer
Chatterton, R. T. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.11.002 · Cited by 1 · see citing works
Doping Status of DHEA Treatment for Female Athletes with Adrenal Insufficiency
Handelsman, D., Matsumoto, A., & Gerrard, D. (2017) · Clinical Journal of Sports Medicine · doi:10.1097/jsm.0000000000000300 · Cited by 2 · see citing works
Glintborg, D., Christensen Louise, L., Kvorning, T., Larsen, R., Brixen, K., Hougaard David, M., Richelsen, B., Bruun Jens, M., & Andersen Marianne, S. (2013) · Endocrine Abstracts · doi:10.1530/endoabs.32.p638 · Cited by 1 · see citing works
DHEA, -oppskrytt kosttilskudd eller viktig hormon? En litteraturstudie
Solli, S. L. A. (2014) · NORA - Norwegian Open Research Archives
Landi, F., Onder, G., & Rolland, Y. (2021) · doi:10.1002/9781119597896.ch25
- Authors
- Christiansen, J. J., Bruun, J. M., Christiansen, J. S., Jørgensen, J. O., & Gravholt, C. H.
- Affiliations
- Aarhus University Hospital (DK)
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08
- Volume
- 165
- Issue
- 2
- Pages
- 293-300
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2164848873
- Cited by
- 26
- References
- 38
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2018: 4 · 2016: 2 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- adrenal insufficiency, female patients, androgen replacement, body composition, lean body mass, fat mass, bone metabolism, bone mineral content, parathyroid hormone, fuel metabolism, VO2max, inflammatory markers, adipose tissue inflammation, skeletal muscle inflammation
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Insufficiency, Adult, Body Composition, Bone and Bones, Dehydroepiandrosterone, Double-Blind Method, Drug Administration Schedule, Female, Humans, Middle Aged, Placebos, Time Factors, Muscle, Skeletal, Cross-Over Studies, Hormone Replacement Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
