Cited by 291Thyroid Disorders and TreatmentsHeart Failure Treatment and ManagementCardiovascular Function and Risk Factors

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MECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction

Biondi, Bernadette·2012·European Journal of Endocrinology

DOI 10.1530/eje-12-0627

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Abstract

Context: Heart failure (HF) is a major cause of morbidity and mortality in Europe and in the United States. The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction. Evidence Acquisition: Reports published with the following search terms were searched:, thyroid, hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, levothyroxine, triiodothyronine, antithyroid drugs, radioiodine, deiodinases, clinical symptoms, heart rate, HF, systolic function, diastolic function, systemic vascular resistance, endothelial function, amiodarone and atrial fibrillation. The investigation was restricted to reports published in English. Evidence Synthesis: The outcome of this analysis suggests that patients with untreated overt thyroid dysfunction are at increased risk of HF. Moreover, persistent subclinical thyroid dysfunction is associated with the development of HF in patients with serum TSH <0.1 or >10 mU/l. Conclusions: The timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction.

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Self-citation
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Authors: Biondi, B.
Affiliations: Federico II University Hospital (IT)
Corresponding author: Biondi, Bernadette
ORCID: Biondi, Bernadette
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2012-11
Volume: 167
Issue: 5
Pages: 609-618
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje-12-0627
OpenAlex: W2071292391
Cited by: 291
References: 105
Citations by year: 2026: 8 · 2025: 15 · 2024: 13 · 2023: 17 · 2022: 19 · 2021: 26 · 2020: 24 · 2019: 26 · 2018: 23 · 2017: 28 · 2016: 24 · 2015: 23 · 2014: 21 · 2013: 17 · 2012: 3
FWCI: 2.83
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: heart failure, thyroid dysfunction, subclinical hypothyroidism, subclinical hyperthyroidism, overt hypothyroidism, overt hyperthyroidism, thyroid hormone replacement, levothyroxine, triiodothyronine, antithyroid drugs, radioactive iodine, deiodinases, systolic function, diastolic function, endothelial function, amiodarone, atrial fibrillation, heart rate, systemic vascular resistance
MeSH terms: Amiodarone, Animals, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Coronary Disease, Heart Failure, Heart Rate, Humans, Hyperthyroidism, Hypothyroidism, Prognosis, Stroke Volume, Thyroid Diseases, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Practice Guidelines as Topic, Disease Progression, Evidence-Based Medicine

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MECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction

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