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Cited by 165Parathyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal Regulation and Hypertension

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Cardiovascular manifestations of primary hyperparathyroidism: a narrative review

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Pepe, Jessica, Cipriani, Cristiana, Sonato, Chiara, Raimo, Orlando, Biamonte, Federica, Minisola, Salvatore·2017·European Journal of Endocrinology
DOI 10.1530/eje-17-0485
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Abstract

Data on cardiovascular disease in primary hyperparathyroidism (PHPT) are controversial; indeed, at present, cardiovascular involvement is not included among the criteria needed for parathyroidectomy. Aim of this narrative review is to analyze the available literature in an effort to better characterize cardiovascular involvement in PHPT. Due to physiological effects of both parathyroid hormone (PTH) and calcium on cardiomyocyte, cardiac conduction system, smooth vascular, endothelial and pancreatic beta cells, a number of data have been published regarding associations between symptomatic and mild PHPT with hypertension, arrhythmias, endothelial dysfunction (an early marker of atherosclerosis), glucose metabolism impairment and metabolic syndrome. However, the results, mainly derived from observational studies, are inconsistent. Furthermore, parathyroidectomy resulted in conflicting outcomes, which may be linked to several potential biases. In particular, differences in the methods utilized for excluding confounding co-existing cardiovascular risk factors together with differences in patient characteristics, with varying degrees of hypercalcemia, may have contributed to these discrepancies. The only meta-analysis carried out in PHPT patients, revealed a positive effect of parathyroidectomy on left ventricular mass index (a predictor of cardiovascular mortality) and more importantly, that the highest pre-operative PTH levels were associated with the greatest improvements. In normocalcemic PHPT, it has been demonstrated that cardiovascular risk factors are almost similar compared to hypercalcemic PHPT, thus strengthening the role of PTH in the cardiovascular involvement. Long-term longitudinal randomized trials are needed to determine the impact of parathyroidectomy on cardiovascular diseases and mortality in PHPT.

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  1. 2008, Coronary artery calcification in patients with primary hyperparathyroidism in comparison with control subjects from the multi-ethnic study of atherosclerosis, Endocrine Practice, 14, 155, 10.4158/EP.14.2.155 · DOI
  2. 2016, Patients with normocalcemic primary hyperparathyroidism may have similar metabolic profile as hypercalcemic patients, Endocrine Journal, 63, 111, 10.1507/endocrj.EJ15-0392 · DOI
  3. 2012, Aortic valve calcification in mild primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 97, 132, 10.1210/jc.2011-2107 · DOI
  4. 1994, Impaired glucose tolerance and insulin insensitivity in primary hyperparathyroidism, Clinical Endocrinology, 40, 47, 10.1111/j.1365-2265.1994.tb02442.x · DOI
  5. 2017, The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism, Endocrine, 55, 283, 10.1007/s12020-016-1175-3 · DOI
  6. 2016, A pilot study investigating the effect of parathyroidectomy on arterial stiffness and coronary artery calcification in patients with primary hyperparathyroidism, Surgery, 159, 218, 10.1016/j.surg.2015.07.037 · DOI
  7. 1991, The prevalence of diabetes mellitus in patients with primary hyperparathyroidism and among their relatives, Diabetic Medicine, 8, 683, 10.1111/j.1464-5491.1991.tb01678.x · DOI
  8. 2016, High prevalence of abdominal aortic calcification in patients with primary hyperparathyroidism as evaluated by Kauppila score, European Journal of Endocrinology, 175, 95, 10.1530/EJE-15-1152 · DOI
  9. 2016, Adipokines and bone metabolism: an interplay to untangle, Journal of Endocrinological Investigation, 39, 1359, 10.1007/s40618-016-0549-y · DOI
  10. 2008, Parathyroid hormone stimulates the endothelial expression of vascular endothelial growth factor, European Journal of Clinical Investigation, 38, 798, 10.1111/j.1365-2362.2008.02033.x · DOI
  11. 2013, Effect of gender and geographic location on the expression of primary hyperparathyroidism, Journal of Endocrinological Investigation, 36, 123
  12. 2017, Primary hyperparathyroidism predicts hypertension: results from the National Inpatient Sample, International Journal of Cardiology, 227, 335, 10.1016/j.ijcard.2016.11.080 · DOI
  13. 2015, Prevalence of kidney stones and vertebral fractures in primary hyperparathyroidism using imaging technology, Journal of Clinical Endocrinology and Metabolism, 100, 1309, 10.1210/jc.2014-3708 · DOI
  14. 2011, Mild primary hyperparathyroidism: vitamin D deficiency and cardiovascular risk markers, Journal of Clinical Endocrinology and Metabolism, 296, 2112
  15. 2010, Cardiac structure and diastolic function in mild primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 95, 2172, 10.1210/jc.2009-2072 · DOI
  16. 2000, Effects of successful parathyroidectomy on altered arterial reactivity in patients with hypercalcaemia: results of a 3-year follow-up study, Clinical Endocrinology, 53, 229, 10.1046/j.1365-2265.2000.01076.x · DOI
  17. 2011, Hypertension secondary to PHPT: cause or coincidence?, International Journal of Endocrinology, 2011, 6
  18. 2013, Arrhythmias in primary hyperparathyroidism evaluated by exercise test, European Journal of Clinical Investigation, 43, 208, 10.1111/eci.12038 · DOI
  19. 2005, Maintained normalization of cardiovascular dysfunction 5 years after parathyroidectomy in primary hyperparathyroidism, Surgery, 137, 632, 10.1016/j.surg.2005.02.001 · DOI
  20. 2012, Sudden cardiac death and genetic ion channelopathies: long QT, Brugada, short QT, catecholaminergic polymorphic ventricular tachycardia, and idiopathic ventricular fibrillation, Circulation, 125, 2027, 10.1161/CIRCULATIONAHA.111.055947 · DOI
  21. 2016, Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: results from the EPATH randomized, placebo-controlled trial, Journal of Hypertension, 34, 1347, 10.1097/HJH.0000000000000927 · DOI · Paper page
  22. 2010, Parathyroidectomy erase increased myocardial electrical vulnerability in patients with primary hyperparathyroidism, International Journal of Cardiology, 141, 201, 10.1016/j.ijcard.2008.11.067 · DOI
  23. 2013, Primary hyperparathyroidism and metabolic risk factors, impact of parathyroidectomy and vitamin D supplementation, and results of a randomized double-blind study, European Journal of Endocrinology, 69, 795
  24. 2015, The diagnosis and management of hypercalcaemia, BMJ, 350, h2723, 10.1136/bmj.h2723 · DOI
  25. 2014, Cardiovascular risk and metabolic syndrome in primary hyperparathyroidism and their correlation to different clinical forms, Endocrine, 47, 581, 10.1007/s12020-013-0091-z · DOI
  26. 2010, Effect of successful parathyroidectomy on 24-h ambulatory blood pressure in patients with primary hyperparathyroidism, International Journal of Cardiology, 142, 15, 10.1016/j.ijcard.2008.12.027 · DOI
  27. 1997, Prevalence of primary hyperparathyroidism in patients with diabetes mellitus, Diabetic Medicine, 14, 386, 10.1002/(SICI)1096-9136(199705)14:5<386::AID-DIA362>3.0.CO;2-3 · DOI
  28. 2012, Factors influencing insulin sensitivity in patients with mild primary hyperparathyroidism before and after parathyroidectomy, Scandinavian Journal of Clinical and Laboratory Investigation, 72, 92, 10.3109/00365513.2011.634432 · DOI
  29. 2004, Ventricular fibrillation in hypercalcaemic crisis due to primary hyperparathyroidism, Netherland Journal of Medicine, 62, 94
  30. 2009, Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidism, Surgery, 146, 1042, 10.1016/j.surg.2009.09.024 · DOI
  31. 2012, Arterial hypertension, metabolic syndrome and subclinical cardiovascular organ damage in patients with asymptomatic primary hyperparathyroidism before and after parathyroidectomy: preliminary results, International Journal of Endocrinology, 2012, 1
  32. 2011, Mild primary hyperparathyroidism: vitamin D deficiency and cardiovascular risk markers, Journal of Clinical Endocrinology and Metabolism, 96, 2112, 10.1210/jc.2011-0238 · DOI
  33. 2001, Arterial distensibility and pulse wave velocity in patients with primary hyperparathyroidism before and after parathyroidectomy, Clinical Nephrology, 55, 303
  34. 2012, Prevalence and characteristics of metabolic syndrome in primary hyperparathyroidism, Journal of Endocrinological Investigation, 35, 841
  35. 1990, Specific inhibition of long-lasting, L-type calcium channels by synthetic parathyroid hormone, PNAS, 87, 623, 10.1073/pnas.87.2.623 · DOI
  36. 2016, Impact of ethnic background on clinical characteristics and cardiovascular risk factors among patients with primary hyperparathyroidism, Endocrine Practice, 22, 323, 10.4158/EP15951.OR · DOI
  37. 2000, Augmentation of central arterial pressure in mild primary hyperparathyroidism., Journal of Clinical Endocrinology and Metabolism, 85, 3515, 10.1210/jcem.85.10.6880 · DOI
  38. 2007, Impairment of flow mediated vasodilatation of brachial artery in patients with primary hyperparathyroidism, International Journal of Cardiovascular Imaging, 23, 323, 10.1007/s10554-006-9166-8 · DOI
  39. 2015, Impaired endothelial function in patients with mild primary hyperparathyroidism improves after parathyroidectomy, Clinical Endocrinology, 83, 951, 10.1111/cen.12666 · DOI
  40. 2013, Endothelial function in mild primary hyperparathyroidism, Clinical Endocrinology, 78, 204, 10.1111/j.1365-2265.2012.04485.x · DOI
  41. 2016, Parathyroidectomy in asymptomatic primary hyperparathyroidism reduces carotid intima-media thickness and arterial stiffness, Clinical Endocrinology, 84, 39, 10.1111/cen.12952 · DOI
  42. 2009, Evaluation of subclinical coronary atherosclerosis in mild asymptomatic primary hyperparathyroidism patients, International Journal of Cardiovascular Imaging, 25, 187, 10.1007/s10554-008-9369-2 · DOI
  43. 2016, Explaining geographical variation in the presentation of primary hyperparathyroidism, Lancet Diabetes and Endocrinology, 4, 641, 10.1016/S2213-8587(16)00076-0 · DOI
  44. 2015, Is normocalcemic primary hyperparathyroidism harmful or harmless?, Journal of Clinical Endocrinology and Metabolism, 100, 2420, 10.1210/jc.2014-4432 · DOI
  45. 2006, Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening, European Journal of Endocrinology, 155, 33, 10.1530/eje.1.02173 · DOI
  46. 2000, Impaired flow mediated vasodilation of the brachial artery in patients with primary hyperparathyroidism improves after parathyroidectomy, Cardiovascular Research, 47, 813, 10.1016/S0008-6363(00)00130-9 · DOI
  47. 2012, Prevalence of cardiovascular risk factors in male and female patients with primary hyperparathyroidism, Journal of Endocrinological Investigation, 35, 548
  48. 2007, Primary hyperparathyroidism, insulin resistance, and cardiovascular disease: a review, Nursing Clinics of North America, 42, 79, 10.1016/j.cnur.2006.11.010 · DOI
  49. 2011, Effect of surgery on cardiac structure and function in mild primary hyperparathyroidism, Clinical Endocrinology, 74, 174, 10.1111/j.1365-2265.2010.03909.x · DOI
  50. 2009, Cardiovascular risk factors in primary hyperparathyroidism, Journal of Endocrinological Investigation, 32, 317, 10.1007/BF03345719 · DOI
  51. 2012, Adrenergic and cardiac dysfunction in primary hyperparathyroidism, Clinical Endocrinology, 76, 189, 10.1111/j.1365-2265.2011.04169.x · DOI
  52. 2006, Intima-media thickness measurement of the carotid artery in patients with primary hyperparathyroidism. A prospective case-control study and long-term follow-up, In Vivo, 20, 887
  53. 2010, Long-term effects of parathyroidectomy on hypertension prevalence and circadian blood pressure profile in primary hyperparathyroidism, Clinical and Experimental Hypertension, 32, 154, 10.3109/10641960903254471 · DOI
  54. 2012, Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+- Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation, Circulation, 125, 2059, 10.1161/CIRCULATIONAHA.111.067306 · DOI
  55. 2011, Large-artery stiffness: a reversible marker of cardiovascular risk in primary hyperparathyroidism, Atherosclerosis, 218, 96, 10.1016/j.atherosclerosis.2011.05.010 · DOI
  56. 2010, Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging, European Journal of Nuclear Medicine Molecular Imaging, 37, 2256, 10.1007/s00259-010-1599-6 · DOI
  57. 2011, Sporadic and hereditary primary hyperparathyroidism, Journal of Endocrinological Investigation, 34, 40
  58. 2000, Insulin sensitivity is inversely correlated with plasma intact parathyroid hormone level, Metabolism, 49, 1501, 10.1053/meta.2000.17708 · DOI
  59. 2000, Studies on flow-mediated vasodilation and intima-media thickness of the brachial artery in patients with primary hyperparathyroidism, American Journal of Hypertension, 13, 759, 10.1016/S0895-7061(00)00248-X · DOI
  60. 1994, Primary hyperparathyroidism and hypertension: persistently abnormal pressor sensitivity in normotensive patients after surgical cure, Journal of Endocrinological Investigation, 17, 307, 10.1007/BF03348986 · DOI
  61. 2005, Arterial stiffness in mild primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 90, 3326, 10.1210/jc.2004-1400 · DOI · Paper page
  62. 2009, Carotid vascular abnormalities in primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 94, 3849, 10.1210/jc.2009-1086 · DOI
  63. 2009, Sporadic and MEN1-related primary hyperparathyroidism: differences in clinical expression and severity, Journal of Bone and Mineral Research, 24, 1404, 10.1359/jbmr.090304 · DOI
  64. 1999, Endothelial vasodilatory dysfunction in primary hyperparathyroidism is reversed after parathyroidectomy, Surgery, 126, 1049, 10.1067/msy.2099.101422 · DOI
  65. 2016, A pilot study investigating the effect of parathyroidectomy on arterial stiffness and coronary artery calcification in patients with primary hyperparathyroidism, Surgery, 159, 218, 10.1016/j.surg.2015.07.037 · DOI
  66. 2017, Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus, Osteoporosis International, 28, 1, 10.1007/s00198-016-3716-2 · DOI
  67. 2005, Circulation, 112, 2735, 10.1161/CIRCULATIONAHA.105.169404 · DOI · Paper page
  68. 2008, Parathyroid hormone and the cardiovascular system, Current Osteoporosis Report, 6, 77, 10.1007/s11914-008-0014-8 · DOI
  69. 2015, Effect of parathyroidectomy upon left ventricular mass in primary hyperparathyroidism: a meta-analysis, Journal of Clinical Endocrinology and Metabolism, 100, 4399, 10.1210/jc.2015-3202 · DOI
  70. 2011, Electrolyte disorders and arrhythmogenesis, Cardiology Journal, 18, 233
  71. 2014, Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts, Arteriosclerosis, Thrombosis, and Vascular Biology, 34, 1567, 10.1161/ATVBAHA.113.303062 · DOI · Paper page
  72. 2010, Cardiovascular risk factors and arterial rigidity are similar in asymptomatic normocalcemic and hypercalcemic primary hyperparathyroidism, European Journal of Endocrinology, 162, 925, 10.1530/EJE-09-1067 · DOI
  73. 1994, Regulation of vascular endothelial barrier function, American Journal of Physiology, 267, 223
  74. 2007, Increased risk of cardiac death in primary hyperparathyroidism: what is a role of electrical instability?, International Journal of Cardiology, 121, 200, 10.1016/j.ijcard.2006.08.072 · DOI
  75. 2013, Parathyroid hormone and cardiovascular disease events: a systematic review and meta-analysis of prospective studies, American Heart Journal, 165, 655, 10.1016/j.ahj.2013.02.014 · DOI
  76. 1998, Cardiovascular actions of parathyroid hormone and parathyroid hormone-related peptide, Cardiovascular Research, 37, 34, 10.1016/S0008-6363(97)00194-6 · DOI
  77. 2007, Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism, Metabolism, 56, 30, 10.1016/j.metabol.2006.08.019 · DOI
  78. 2005, Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism, Journal of Human Hypertension, 19, 901, 10.1038/sj.jhh.1001907 · DOI
  79. 2008, Cardiovascular aspects of primary hyperparathyroidism, Journal of Endocrinological Investigation, 31, 925, 10.1007/BF03346443 · DOI
  80. 2014, Investigation of glucose intolerance in patients with normocalcemic primary hyperparathyroidism: 4-year follow-up, Endocrine, 47, 971, 10.1007/s12020-014-0263-5 · DOI
  81. 2011, Arterial blood pressure, serum calcium and PTH in elderly men with parathyroid tumors and primary hyperparathyroidism, Anticancer Research, 31, 3969
  82. 2002, Relationship between serum parathyroid hormone, serum calcium and arterial blood pressure in patients with primary hyperparathyroidism: results of a multivariate analysis, European Journal of Endocrinology, 146, 643
  83. 2009, Effect of surgery on cardiovascular risk factors in mild primary hyperparathyroidism., Journal of Clinical Endocrinology and Metabolism, 94, 2255, 10.1210/jc.2008-2742 · DOI
  84. 2014, Hemodynamic markers and subclinical atherosclerosis in postmenopausal women with primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 99, 2704, 10.1210/jc.2013-4273 · DOI
  85. 2013, Nontraditional manifestations of primary hyperparathyroidism, Journal of Clinical Densitometry, 16, 40, 10.1016/j.jocd.2012.11.008 · DOI
  86. 2013, Parathyroidectomy eliminates arrhythmic risk in primary hyperparathyroidism, as evaluated by exercise test, European Journal of Endocrinology, 169, 255, 10.1530/EJE-13-0293 · DOI
  87. Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways of, American Journal Physiology Renal Physiology, 2007292, 10.1152/ajprenal.00406.2006 · DOI
  88. 2017, Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: the EPATH trial, PLoS ONE, 12, e0173799, 10.1371/journal.pone.0173799 · DOI
  89. 1990, Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study, New England Journal of Medicine, 322, 1561, 10.1056/NEJM199005313222203 · DOI · Paper page
  90. 2015, The effect of parathyroidectomy on insulin sensitivity in patients with primary hyperparathyroidism—an never ending story?, Experimental and Clinical Endocrinology and Diabetes, 123, 336, 10.1055/s-0035-1549906 · DOI
  91. 1994, Serum calcium and the ECG in patients with primary hyperparathyroidism, Journal of Electrocardiology, 27, 99, 10.1016/S0022-0736(05)80092-5 · DOI
  92. 1992, Cardiovascular responsiveness to parathyroid hormone (PTH) and PTH-related protein in genetic hypertension, Endocrinology, 130, 2045
  93. 2009, Insulin resistance is not coupled with defective insulin secretion in primary hyperparathyroidism, Diabetic Medicine, 26, 968, 10.1111/j.1464-5491.2009.02804.x · DOI
  94. 2016, Effect of curative parathyroidectomy on insulin resistance, Indian Journal of Endocrinology and Metabolism, 20, 784, 10.4103/2230-8210.192916 · DOI
  95. 2002, Increased intima-media thickness of the carotid artery wall, normal blood pressure profile and normal left ventricular mass in subjects with primary hyperparathyroidism, European Journal of Endocrinology, 147, 453
  96. 2005, Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland population, Diabetes, 54, 3336, 10.2337/diabetes.54.11.3336 · DOI
  97. 2014, Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop, Journal of Clinical Endocrinology and Metabolism, 99, 3580, 10.1210/jc.2014-1415 · DOI
  98. 2000, Ventricular tachycardia in a patient with primary hyperparathyroidism, Pacing and Clinical Electrophysiology, 23, 534, 10.1111/j.1540-8159.2000.tb00842.x · DOI
  99. 2012, Effect of parathyroidectomy on subclinical cardiovascular disease in mild primary hyperparathyroidism, European Journal of Endocrinology, 167, 277, 10.1530/EJE-12-0124 · DOI
  100. 2003, Ultrasound evaluation of carotid artery in primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 88, 2096, 10.1210/jc.2002-021837 · DOI
  101. 2010, Cardiac function in mild primary hyperparathyroidism and the outcome after parathyroidectomy, European Journal of Endocrinology, 163, 461, 10.1530/EJE-10-0201 · DOI
  102. 2012, Arterial structure and function in mild primary hyperparathyroidism is not directly related to parathyroid hormone, calcium, or vitamin D, PLoS ONE, 7, e39519, 10.1371/journal.pone.0039519 · DOI
  103. 2011, Mild primary hyperparathyroidism: vitamin D deficiency and cardiovascular risk markers, Journal of Clinical Endocrinology and Metabolism, 296, 2112
  104. 1998, Survival after the diagnosis of hyperparathyroidism: a population based study, American Journal of Medicine, 104, 115, 10.1016/S0002-9343(97)00270-2 · DOI
  105. 2010, Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS), Clinical Endocrinology, 73, 30, 10.1111/j.1365-2265.2009.03766.x · DOI
  106. 2014, Evaluation of left ventricle functions by tissue doppler, strain, and strain rate echocardiography in patients with primary hyperparathyroidism, Endocrine, 47, 609, 10.1007/s12020-014-0245-7 · DOI
  107. 2014, Aldosterone and parathyroid hormone interactions as mediators of metabolic and cardiovascular disease, Metabolism, 63, 20, 10.1016/j.metabol.2013.08.016 · DOI
  108. 2013, Normocalcemic primary hyperparathyroidism, Journal of Clinical Densitometry, 16, 33, 10.1016/j.jocd.2012.12.001 · DOI
  109. 2016, A pilot study investigating the effect of parathyroidectomy on arterial stiffness and coronary artery calcification in patients with primary hyperparathyroidism, Surgery, 159, 218, 10.1016/j.surg.2015.07.037 · DOI
  110. 1997, Survival after surgical treatment for primary hyperparathyroidism, Surgery, 122, 1117, 10.1016/S0039-6060(97)90216-6 · DOI
  111. 2011, Effects of successful parathyroidectomy on metabolic cardiovascular risk factors in patients with severe primary hyperparathyroidism, Endocrine Practice, 17, 584, 10.4158/EP10321.OR · DOI
  112. 2014, Relationship between insulin sensitivity and bone mineral density in primary hyperparathyroidism, Clinical Endocrinology, 81, 350, 10.1111/cen.12472 · DOI
  113. 2015, Mortality associated with primary hyperparathyroidism, Bone, 74, 121, 10.1016/j.bone.2014.12.067 · DOI
  114. 2009, Serum aldosterone is correlated positively to parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism, Surgery, 146, 1035, 10.1016/j.surg.2009.09.041 · DOI · Paper page
  115. 2008, Prevalence of type 2 diabetes mellitus in patients with primary hyperparathyroidism, Endocrine Practice, 14, 69, 10.4158/EP.14.1.69 · DOI
  116. 2011, QT-interval duration and mortality rate: results from the Third National Health and Nutrition Examination Survey, Archives of Internal Medicine, 171, 1727, 10.1001/archinternmed.2011.433 · DOI
  117. 2014, Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop, Journal of Clinical Endocrinology and Metabolism, 99, 3561, 10.1210/jc.2014-1413 · DOI
  118. 2016, Parathyroid hormone, aldosterone-to-renin ratio and fibroblast growth factor-23 as determinants of nocturnal blood pressure in primary hyperparathyroidism: the eplerenone in primary hyperparathyroidism trial, Journal of Hypertension, 34, 1778, 10.1097/HJH.0000000000001004 · DOI · Paper page
  119. 2011, Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy, Hypertension Research, 34, 296, 10.1038/hr.2010.232 · DOI
  120. 2015, High prevalence of metabolic syndrome in a mestizo group of adult patients with primary hyperparathyroidism (PHPT)., BMC Endocrine Disorders, 15, 16, 10.1186/s12902-015-0014-5 · DOI
  121. 2012, Coronary microvascular dysfunction induced by primary hyperparathyroidism is restored after parathyroidectomy, Circulation, 126, 1031, 10.1161/CIRCULATIONAHA.111.081307 · DOI
  122. 2004, Primary hyperparathyroidism and heart disease—a review, European Heart Journal, 25, 1776, 10.1016/j.ehj.2004.07.010 · DOI
  123. 2006, Changes in insulin sensitivity and glucose and bone metabolism over time in patients with asymptomatic primary hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 91, 4260, 10.1210/jc.2005-2825 · DOI
  124. 2017, Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial, Clinical Chemistry and Laboratory Medicine, 55, 1034
  125. 2016, Normocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidism., Journal of Bone and Mineral Metabolism, 34, 331, 10.1007/s00774-015-0673-3 · DOI

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Metadata

Authors
Pepe, J., Cipriani, C., Sonato, C., Raimo, O., Biamonte, F., & Minisola, S.
Affiliations
Sapienza University of Rome (IT)
Corresponding author
Pepe, Jessica
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2017-12
Volume
177
Issue
6
Pages
R297-R308
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-17-0485
OpenAlex
W2753358648
Cited by
165
References
126
Citations by year
2026: 13 · 2025: 17 · 2024: 21 · 2023: 25 · 2022: 16 · 2021: 23 · 2020: 23 · 2019: 15 · 2018: 12
FWCI
1.83
Type
journal article
Language
en
Open access
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
primary hyperparathyroidism, cardiovascular manifestations, parathyroidectomy, parathyroid hormone, hypercalcemia, hypertension, cardiac arrhythmias, endothelial dysfunction, atherosclerosis, glucose metabolism, metabolic syndrome, left ventricular mass, cardiovascular risk factors, cardiovascular mortality
MeSH terms
Animals, Cardiovascular Diseases, Combined Modality Therapy, Humans, Hypercalcemia, Parathyroid Hormone, Risk Factors, Severity of Illness Index, Parathyroidectomy, Evidence-Based Medicine, Glucose Metabolism Disorders, Hyperparathyroidism, Primary

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