The role of parathyroidectomy in treating hypertension and other cardiac manifestations of primary hyperparathyroidism
Open accessAbstract
Among many recognized sequelae of primary hyperparathyroidism (PHPT), cardiovascular disease remains incompletely understood as a consequence of disordered calcium and parathyroid hormone (PTH) metabolism. While population studies have identified trends that associate PHPT with hypertension, metabolic syndrome, and vascular system calcifications, the fundamental pathophysiology, natural history, and opportunity to reverse or cure the cardiovascular effects with parathyroidectomy are not well established. This chapter reviews the current knowledge of this field of interest within PHPT and summarizes key findings from dedicated investigations that have addressed the impact of parathyroid surgery on the cardiovascular system.
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- Authors
- Nelson, J. A., Alsayed, M., & Milas, M.
- Affiliations
- University of Michigan (US)
- Banner - University Medical Center Phoenix (US)
- Corresponding author
- Nelson, J. Alex
- ORCID
- Milas, Mira
- Venue
- Gland Surgery
- Publisher
- AME Publishing Company
- Published
- 2020-02
- Volume
- 9
- Issue
- 1
- Pages
- 136-141
- ISSN
- 2227-684X (ISSN-L)
- 2227-8575
- PMC
- PMC7082270
- OpenAlex
- W2998885849
- Cited by
- 27
- References
- 18
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 3 · 2020: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Gland Surgery (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- primary hyperparathyroidism, parathyroidectomy, hypertension, cardiovascular disease, parathyroid hormone, calcium metabolism, vascular calcification, metabolic syndrome, cardiac involvement
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