The DOI matches its Crossref record.
Gender differences in secretory activity of the human somatotropic (growth hormone) axis
Abstract
Major gender differences exist in the prevalence and severity of various disease states, rates of organ-specific aging and drug and hormone metabolism. Increased understanding of the mechanistic bases for these important sex differences is likely to stimulate new prognostic, therapeutic and diagnostic insights over many succeeding decades. I will outline clinical data that bear on regulatory mechanisms that give rise to sex-based differences in the neuroendocrine activity of the human somatotropic (GH) axis. Such studies have important implications in both pubertal and gonadoprival states, such as aging and the menopause, when the sex-steroid milieu changes dramatically.
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“The proposal that the sex difference in muscle mass and function might be due to sex differences in endogenous GH secretion (116) is refuted by the extensive and conclusive clinical evidence that endogenous GH secretion in young women is consistently higher (typically twice as high) as in young men of similar age (163–170).”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [165]
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Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
Self-citationGrowth Hormone, Insulin-Like Growth Factors, and the Skeleton
Giustina, A., Mazziotti, G., & CANALIS, E. M. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0036 · Cited by 932
Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance
Handelsman, D. J., Hirschberg, A. L., & Bermon, S. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00020 · Cited by 594
Growth Hormone (GH)-Deficient Men Are More Responsive to GH Replacement Therapy Than Women
Burman, P., Johansson, A. G., Siegbahn, A., Vessby, B. O., & Karlsson, F. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3776 · Cited by 312
“The basal GH concentration (17), the 24-hour integrated GH secretion (16, 18 , 27), and the pituitary response to GHRH (19, 20) and arginine (28) are higher in premenopausal women than in men of a comparable age.”
BackgroundThe association of breast mitogens with mammographic densities
Boyd, N. F., Stone, J., Martin, L. J., Jong, R. A., Fishell, E., Yaffe, M. J., Hammond, G. L., & Minkin, S. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600537 · Cited by 272
“…evidence that the growth hormone-IGF-I axis plays a role in carcinogenesis in the breast (Pollak, 1998; Ruan et al, 1992) and transgenic mice that over-express IGF-I or growth hormone have an increased incidence of mammary cancer (Tornell et al, 1992; Macaulay, 1992; Ruan et al, 1992; Yee, 1998).”
Background
Metadata
- Authors
- Veldhuis, J. D.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Veldhuis, Johannes D
- ORCID
- Veldhuis, Johannes D
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03
- Volume
- 134
- Issue
- 3
- Pages
- 287-295
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2136396730
- Cited by
- 102
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 3 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 4 · 2012: 1
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- California HIV/AIDS Research Program
- National Institutes of Health (5k04hd000634-02, 5p30dk038942-05)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38942)
- National Center for Research Resources (RR 00847, M01RR000847)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1-K04-HD-00634)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- sex differences, growth hormone, somatotropic axis, neuroendocrine regulation, puberty, gonadectomy, aging, menopause, sex steroids, hormone secretion
- MeSH terms
- Female, Humans, Kinetics, Male, Menstrual Cycle, Neurosecretory Systems, Pulsatile Flow, Sex Characteristics, Growth Hormone, Growth Hormone-Releasing Hormone
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