The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions
Abstract
Proopiomelanocortin (POMC) is the polypeptide precursor of ACTH. First discovered in anterior pituitary corticotroph cells, it has more recently been revealed to have many other physiological aspects. The fine molecular mechanisms of ACTH biosynthesis show that ACTH is but one piece of a puzzle which contains many other peptides. Present in various tIssues, among which are pituitary, hypothalamus, central nervous system and skin, POMC undergoes extensive post-translational processing. This processing is tIssue-specific and generates, depending on the case, various sets of peptides involved in completely diverse biological functions. POMC expressed in corticotroph cells of the pituitary is necessary for adrenal function. Recent developments have shown that POMC-expressing neurons in the brain play a major role in the control of pain and energy homeostasis. Local production of POMC-derived peptides in skin may influence melanogenesis. A still unknown function in the placenta is likely.POMC has become a paradigmatic polypeptide precursor model illustrating the variable roles of a single gene and its various products in different localities.
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Jackson, R. S., Creemers, J. W. M., Ohagi, S., Raffin-Sanson, M.-L., Sanders, L., Montague, C. T., Hutton, J. C., & O'Rahilly, S. (1997) · Nature Genetics · doi:10.1038/ng0797-303 · Cited by 1,153
Self-citationMelanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., & Froguel, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9238 · Cited by 897
Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2002) · Endocrinology · doi:10.1210/en.2002-220338 · Cited by 131
Cited by
D'Orazio, J., Jarrett, S., Amaro-Ortiz, A., & Scott, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612222 · Cited by 1,984
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948
Lacroix, A., Feelders, R. A., Stratakis, C. A., & Nieman, L. K. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61375-1 · Cited by 1,777
Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions
Chapman, C. R., Tuckett, R. P., & Song, C. W. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.006 · Cited by 541
Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity
Paolini, B., Maltese, P. E., Del Ciondolo, I., Tavian, D., Missaglia, S., Ciuoli, C., Zuntini, M., Cecchin, S., Bertelli, M., & Pompucci, G. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15038718 · Cited by 308
Metadata
- Authors
- Raffin-Sanson, M., de Keyzer, Y., & Bertagna, X.
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-08-01
- Volume
- 149
- Issue
- 2
- Pages
- 79-90
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2128822914
- Cited by
- 245
- References
- 3
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
