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RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture
Abstract
Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.
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Cited by
Leboulleux, S., Bastholt, L., Krause, T., de la Fouchardiere, C., Tennvall, J., Awada, A., Gómez, J. M., Bonichon, F., Leenhardt, L., Soufflet, C., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70335-2 · Cited by 375
Genetic Alterations in the Phosphatidylinositol-3 Kinase/Akt Pathway in Thyroid Cancer
Xing, M. (2010) · Thyroid · doi:10.1089/thy.2010.1646 · Cited by 305
Rethinking the role of oncogenes in papillary thyroid cancer initiation
Vitale, M. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00083 · Cited by 10
Metadata
- Authors
- Santoro, M., Melillo, R. M., & Fusco, A.
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11
- Volume
- 155
- Issue
- 5
- Pages
- 645-653
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2150611307
- Cited by
- 190
- References
- 0
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. https://app.cochat.ai/papers/10.1530/eje.1.02289
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- Santoro, M., Melillo, R. M., & Fusco, A. (2006). RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. European Journal of Endocrinology. https://doi.org/10.1530/eje.1.02289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
