Rethinking the role of oncogenes in papillary thyroid cancer initiation

Mutations of the BRAF gene in human cancer

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Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer

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Increasing Incidence of Thyroid Cancer in the United States, 1973-2002

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High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

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BRAF mutation in thyroid cancer

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The RAF proteins take centre stage

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BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

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RET/PTC Rearrangement in Thyroid Tumors

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Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation

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A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

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Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

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High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation

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Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas

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Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.

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Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.

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Increasing Incidence of Thyroid Cancer in the United States, 1973–2002

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RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

Santoro, M. M., Melillo, R. M., & Fusco, A. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02289 · Cited by 190 · see citing works

Thyroid Cancer: Is the Incidence Still Increasing?

Hodgson, N. C. F., Button, J. H., & Solórzano, C. C. (2004) · Annals of Surgical Oncology · doi:10.1245/aso.2004.03.066 · Cited by 170 · see citing works

Radiation-induced thyroid cancer: What we have learned from Chernobyl

Nikiforov, Y. E. (2006) · Endocrine Pathology · doi:10.1007/s12022-006-0001-5 · Cited by 146 · see citing works

The Primary Occurrence ofBRAFV600EIs a Rare Clonal Event in Papillary Thyroid Carcinoma

Guerra, A., Sapio, M. R., Marotta, V., Campanile, E., Rossi, S., Forno, I., Fugazzola, L., Budillon, A., Moccia, T., Fenzi, G., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0618 · Cited by 140 · see citing works

Heterogeneity in the Distribution ofRET/PTCRearrangements within Individual Post-Chernobyl Papillary Thyroid Carcinomas

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Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method.

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A High Percentage of BRAFV600E Alleles in Papillary Thyroid Carcinoma Predicts a Poorer Outcome

Guerra, A., Fugazzola, L., Marotta, V., Círillo, M., Rossi, S., Cirello, V., Forno, I., Moccia, T., Budillon, A., & Vitale, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3106 · Cited by 130 · see citing works

The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.

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BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine-needle aspiration biopsies

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RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint

Marotta, V., Guerra, A., Sapio, M. R., & Vitale, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0499 · Cited by 101 · see citing works

Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse

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Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors inBRAFMutant Thyroid Carcinoma Cells

Salerno, P., Falco, V. D., Tamburrino, A., Nappi, T. C., Vecchio, G., Schweppe, R. E., Bollag, G. E., Santoro, M. M., & Salvatore, G. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0373 · Cited by 97 · see citing works

Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer

Nucera, C., Nehs, M. A., Nagarkatti, S. S., Sadow, P. M., Mekel, M., Fischer, A. H., Lin, P., Bollag, G. E., Lawler, J., Hodin, R. A., et al. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0317 · Cited by 92 · see citing works

Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application

Guerra, A., Sapio, M. R., Marotta, V., Campanile, E., Moretti, M. I., Deandrea, M., Motta, M., Limone, P. P., Fenzi, G., Rossi, G., et al. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-260 · Cited by 76 · see citing works

RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH

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Functional analysis of the regulatory requirements of B-Raf and the B-RafV600E oncoprotein

Brummer, T., Martin, P., Herzog, S., Misawa, Y., Daly, R. J., & Reth, M. G. (2006) · Oncogene · doi:10.1038/sj.onc.1209640 · Cited by 70 · see citing works

High Growth Rate of Benign Thyroid Nodules Bearing RET/PTC Rearrangements

Sapio, M. R., Guerra, A., Marotta, V., Campanile, E., Formisano, R., Deandrea, M., Motta, M., Limone, P. P., Fenzi, G., Rossi, G., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1599 · Cited by 67 · see citing works

Frequent RET Rearrangements in Thyroid Papillary Microcarcinoma Detected by Interphase Fluorescence In Situ Hybridization

Corvi, R., Martínez‐Alfaro, M., Harach, H. R., Zini, M., Papotti, M. G., & Romeo, G. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780377 · Cited by 53 · see citing works

Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif

Moretti, S., Falco, V. D., Tamburrino, A., Barbi, F., Tavano, M., Avenia, N., Santeusanio, F., Santoro, M. M., Macchiarulo, A., & Puxeddu, E. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.001 · Cited by 31 · see citing works

BRAFmutation in cytology samples as a diagnostic tool for papillary thyroid carcinoma

Marotta, V., Sapio, M. R., Guerra, A., & Vitale, M. (2011) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2011.575058 · Cited by 23 · see citing works

Thyroid cancer: Is the incidence still increasing

Hodgson, N., Wohler‐Torres, B., & Solarzano, C. O. D. (2004) · Annals of Surgical Oncology · doi:10.1007/bf02524006 · Cited by 22 · see citing works

Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells

Salerno, P., Falco, V. D., Tamburrino, A., Nappi, T. C., Vecchio, G., Schweppe, R. E., Bollag, G. E., Santoro, M. M., & Salvatore, G. (2009) · Endocrine Reviews · doi:10.1210/edrv.30.7.9986 · Cited by 12 · see citing works

Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse

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Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review

Guerra, A., Crescenzo, V. G. D., Garzi, A., Cinelli, M., Carlomagno, C., Tonacchera, M., Zeppa, P., & Vitale, M. (2013) · BMC Surgery · doi:10.1186/1471-2482-13-s2-s44 · Cited by 95 · see citing works

Concomitant BRAF V600E Mutation and RET/PTC Rearrangement Is a Frequent Occurrence in Papillary Thyroid Carcinoma

Guerra, A., Zeppa, P., Bifulco, M., & Vitale, M. (2013) · Thyroid · doi:10.1089/thy.2013.0235 · Cited by 64 · see citing works

New therapies for dedifferentiated papillary thyroid cancer

Fallahi, P., Mazzi, V., Vita, R., Ferrari, S., Materazzi, G., Galleri, D., Benvenga, S., Miccoli, P., & Antonelli, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16036153 · Cited by 58 · see citing works

Bridging hypoxia, inflammation and estrogen receptors in thyroid cancer progression

Tafani, M., Santis, E. D., Coppola, L., Perrone, G. A., Carnevale, I., Russo, A., Pucci, B., Carpi, A., Bizzarri, M., & Russo, M. A. (2013) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2013.10.013 · Cited by 54 · see citing works

Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study

Schob, S., Voigt, P., Buré, L., Meyer, H., Wickenhauser, C., Behrmann, C., Höhn, A.-K., Kachel, P., Dralle, H., Hoffmann, K., et al. (2016) · Translational Oncology · doi:10.1016/j.tranon.2016.09.001 · Cited by 36 · see citing works

Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells

Chen, H., Luo, D., Zhang, L., Lin, X., Luo, Q., Yi, H., Wang, J., Yan, X., Li, B., Chen, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17398 · Cited by 29 · see citing works

Intratumor BRAF V600E Heterogeneity and Kinase Inhibitors in the Treatment of Thyroid Cancer: A Call for Participation

Vitale, M. (2013) · Thyroid · doi:10.1089/thy.2012.0614 · Cited by 22 · see citing works

Large contribution of copy number alterations in early stage of Papillary Thyroid Carcinoma

Hosseinkhan, N., Honardoost, M., Blighe, K., Moore, T., & Khamseh, M. E. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104584 · Cited by 6 · see citing works

Effects of siRNA-squalene nanoparticles on RET/PTCs junction oncogenes in papillary thyroid carcinoma : from molecular and cellular studies to preclinical investigations

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The ret/PTC oncogene in papillary thyroid carcinoma.

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Papillary Thyroid Carcinoma and RET/PTC Oncogenes

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High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma

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ret/PTC oncogene expression in papillary thyroid carcinoma

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