Effect of cortisol assay bias on the overnight dexamethasone suppression test: implications for the investigation of Cushing's syndrome
Abstract
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The serum cortisol cut-offs after DST do not account for possible variability between analytical methods, which may affect reported values.
“These cut-offs disregard possible variability between analytical methods, which may affect reported values [39,40].”
From Salivary cortisol and cortisone in diagnosis of Cushing's syndrome: a comparison of six different analytical methods (2023) · cites this paper as [40]
Cited by
Sorted by citations
Measuring cortisol in serum, urine and saliva—Are our assays good enough?
El-Farhan, N., Rees, D. A., & Evans, C. (2017) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563216687335 · Cited by 395 · see citing works
“2%, respectively.(113) Diagnosing Cushing’s syndrome can be challenging, as evidenced by the multiple screening tests on offer and cyclical hypercortisolism contributes further diagnostic challenge.”
BackgroundSelf-citationCortisol measurements in Cushing’s syndrome: immunoassay or mass spectrometry?
Casals, G., & Hanzu, F. A. (2020) · Annals of Laboratory Medicine · doi:10.3343/alm.2020.40.4.285 · Cited by 80 · see citing works
“[71] compared the serum cortisol measurement results obtained by mass spectrometry and the automated immunoassays Architect (Abbott), E170 (Roche), Access (Beckman), and Centaur (Siemens).”
MethodResultUse of salivary cortisol and cortisone in the high- and low-dose synacthen test
Elder, C. J., Harrison, R. F., Cross, A. S., Vilela, R., Keevil, B. G., Wright, N. P., & Ross, R. J. (2018) · Clinical Endocrinology · doi:10.1111/cen.13509 · Cited by 21 · see citing works
Serum cortisol assay performance following the 1 mg overnight dexamethasone suppression test
Atkins, J. S., Hawley, J. M., Owen, L. J., Clayton, J. C., Scargill, J., & Keevil, B. G. (2023) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/00045632231179560 · Cited by 15 · see citing works
“12,20 In the previous iteration, positive bias was observed in studies comparing the performance of the assay to GC-MS 14 and LC-MS/MS. 15,21 This assay used polyclonal antibodies targeted at cortisol, which resulted in cross-reactivity with structurally analogous steroids.”
BackgroundSelf-citationCortisol: Analytical and clinical determinants
Vega‐Beyhart, A., Castro, M. A., Hanzu, F. A., & Casals, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.11.005 · Cited by 12 · see citing works
Bäcklund, N., Brattsand, G., Lundstedt, S., Aardal, E., Bartuseviciene, I., Berinder, K., Höybye, C., Burman, P., Edén Engström, B., Isaksson, A., et al. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-0141 · Cited by 9 · see citing works
Improving the Dexamethasone Suppression Test
Keevil, B. G. (2021) · Clinical Chemistry · doi:10.1093/clinchem/hvab076 · Cited by 4 · see citing works
“8mg/dL, with diagnostic sensitivities ranging from 87% to 94% depending on the assay (11).”
BackgroundSelf-citationBiases of large language models in diagnosing Cushing’s syndrome
Savvidis, C., Liakopoulos, C., & Ilias, Ι. (2026) · World Journal of Methodology · doi:10.5662/wjm.v16.i2.115059
- Authors
- Brixey-McCann, R., Tennant, S., Geen, J., Armston, A., Barth, J. H., Keevil, B., Rees, A., & Evans, C.
- Venue
- Endocrine Abstracts
- Publisher
- Bioscientifica
- Published
- 2015-10-12
- ISSN
- 1470-3947 (ISSN-L)
- 1479-6848
- OpenAlex
- W2202393377
- Cited by
- 8
- References
- 0
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 2
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Locations
- Endocrine Abstracts (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- dexamethasone suppression test, Cushing's syndrome, cortisol measurement, diagnostic accuracy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
