Individuals on levothyroxine have higher HADS anxiety and depression scores than the general population and this is exacerbated by the Thr92Ala substitution in DIO2
Abstract
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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We have replicated our findings in the HUNT study in Norway (n = 46,712, n = 1,100 on LT4).
“We have replicated our findings in the HUNT study in Norway (n = 46,712, n = 1,100 on LT4) (44).”
The Thr92Ala SNP was present in 13% of the population and was not associated with increased HADS scores in subjects not receiving LT4.
“The Thr92Ala SNP was present in 13% of the population and was not associated with increased HADS scores in subjects not receiving LT4.”
HADS was 1.83 points higher (0.93-2.73 p <0.001) in those on LT4 who were homozygous for Thr92Ala compared to individuals not on LT4.
“and 1.83 points higher (0.93–2.73 p <0.001) in those on LT4 who were homozygous for Thr92Ala compared to individuals not on LT4.”
Thr92Ala non-homozygous individuals on LT4 were 22% more likely than those not on LT4 to reach the threshold for HADS anxiety.
“Thr92Ala non-homozygous individuals on LT4 were 22% more likely than those not on LT4 to reach the threshold for HADS anxiety”
Thr92Ala homozygous individuals on LT4 were 208% more likely than those not on LT4 to reach the threshold for HADS anxiety.
“whereas homozygous individuals were 208% more likely.”
HADS was 0.71 points higher (0.39-1.02, p <0.001) in subjects on LT4 overall compared to individuals not on LT4.
“HADS was 0.71 points higher (0.39–1.02, p <0.001) in subjects on LT4 overall”
Cited by
Sorted by citations
Premawardhana, L. D., Taylor, P. N., Okosieme, O. E., Adlan, M. A., Obuobie, E. K., & Dayan, C. M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1282608 · Cited by 6 · see citing works
Self-citation
- Authors
- Taylor, P., Haug, E., Heald, A., Premawardhana, L., Okosieme, O., Stedman, M., Asvold, B., & Dayan, C.
- Venue
- Endocrine Abstracts
- Publisher
- Bioscientifica
- Published
- 2022-10-27
- ISSN
- 1470-3947 (ISSN-L)
- 1479-6848
- OpenAlex
- W4307882409
- Cited by
- 1
- References
- 0
- Citations by year
- 2023: 1
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Locations
- Endocrine Abstracts (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- levothyroxine, thyroid hormone replacement, anxiety, depression, Hospital Anxiety and Depression Scale, DIO2, type 2 deiodinase, thyroid hormone metabolism, psychiatric comorbidity
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