The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Role of adipokines in cardiovascular disease
Abstract
The discovery of leptin in 1994 sparked dramatic new interest in the study of white adipose tissue. It is now recognised to be a metabolically active endocrine organ, producing important chemical messengers – adipokines and cytokines (adipocytokines). The search for new adipocytokines or adipokines gained added fervour with the prospect of the reconciliation between cardiovascular diseases (CVDs), obesity and metabolic syndrome. The role these new chemical messengers play in inflammation, satiety, metabolism and cardiac function has paved the way for new research and theories examining the effects they have on (in this case) CVD. Adipokines are involved in a ‘good–bad’, yin–yang homoeostatic balance whereby there are substantial benefits: cardioprotection, promoting endothelial function, angiogenesis and reducing hypertension, atherosclerosis and inflammation. The flip side may show contrasting, detrimental effects in aggravating these cardiac parameters.
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1 retracted
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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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Cited by
The role of adipokines in health and disease
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11051290 · Cited by 463
Perivascular adipose tissue inflammation in vascular disease
Nosalski, R., & Guzik, T. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13705 · Cited by 398
Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis
Alexopoulos, N., Katritsis, D., & Raggi, P. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.023 · Cited by 332
Obesity or bmi paradox? beneath the tip of the iceberg
Donini, L. M., Pinto, A., Giusti, A. M., Lenzi, A., & Poggiogalle, E. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00053 · Cited by 264
Yu, N., Ruan, Y., Gao, X., & Sun, J. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0042-121605 · Cited by 120
Metadata
- Authors
- Mattu, H. S., & Randeva, H. S.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2012-11-16
- Volume
- 216
- Issue
- 1
- Pages
- T17-T36
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2172142004
- Cited by
- 292
- References
- 22
- FWCI
- 19.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
