The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Anorexia nervosa and bone
Open accessAbstract
Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone mass, impaired bone structure, and reduced bone strength, all of which contribute to increased fracture risk. Adolescents with AN have decreased rates of bone accrual compared with normal-weight controls, raising additional concerns of suboptimal peak bone mass and future bone health in this age group. Changes in lean mass and compartmental fat depots, and hormonal alterations secondary to nutritional factors contribute to impaired bone metabolism in AN. The best strategy to improve bone density is to regain weight and menstrual function. Oral estrogen–progesterone combinations are not effective in increasing bone density in adults or adolescents with AN, and transdermal testosterone replacement is not effective in increasing bone density in adult women with AN. However, physiological estrogen replacement as transdermal estradiol with cyclic progesterone does increase bone accrual rates in adolescents with AN to approximate that in normal-weight controls, leading to a maintenance of bone density Z-scores. A recent study has shown that risedronate increases bone density at the spine and hip in adult women with AN. However, bisphosphonates should be used with great caution in women of reproductive age, given their long half-life and potential for teratogenicity, and should be considered only in patients with low bone density and clinically significant fractures when non-pharmacological therapies for weight gain are ineffective. Further studies are necessary to determine the best therapeutic strategies for low bone density in AN.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846
Recombinant human leptin in women with hypothalamic amenorrhea
Welt, C. K., Chan, J. L., Bullen, J., Murphy, R., Smith, P., DePaoli, A. M., Karalis, A., & Mantzoros, C. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040388 · Cited by 908
International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions
Lewiecki, E. M., Gordon, C. M., Baim, S., Leonard, M. B., Bishop, N. J., Bianchi, M.-L., Kalkwarf, H. J., Langman, C. B., Plotkin, H., Rauch, F., et al. (2008) · Bone · doi:10.1016/j.bone.2008.08.106 · Cited by 583
Hamrick, M. W., Della-Fera, M. A., Choi, Y.-H., Pennington, C., Hartzell, D., & Baile, C. A. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050103 · Cited by 268 · cited 1×
“While central leptin is deleterious to the axial skeleton (Ducy et al. 2000, Hamrick et al. 2004), peripheral leptin has bone anabolic effects (with possible osteoclast inhibitory effects as well), particularly on the appendicular skeleton (Hamrick et al. 2004, Hamrick et al. 2005).”
Cited by
MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management
Mirza, F., & Canalis, E. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0118 · Cited by 331
Effects of reduced energy availability on bone metabolism in women and men
Papageorgiou, M., Elliott-Sale, K. J., Parsons, A., Tang, J. C. Y., Greeves, J. P., Fraser, W. D., & Sale, C. (2017) · Bone · doi:10.1016/j.bone.2017.08.019 · Cited by 159
Solmi, M., Veronese, N., Correll, C. U., Favaro, A., Santonastaso, P., Caregaro, L., Vancampfort, D., Luchini, C., De Hert, M., & Stubbs, B. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12556 · Cited by 124
How to manage osteoporosis before the age of 50.
Rozenberg, S., Bruyère, O., Bergmann, P., Cavalier, E., Gielen, E., Goemaere, S., Kaufman, J. M., Lapauw, B., Laurent, M. R., De Schepper, J., et al. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.05.004 · Cited by 118
Villa, P., Cipolla, C., Amar, I., Sodero, G., Pane, L. C., Ingravalle, F., Pontecorvi, A., & Scambia, G. (2024) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01487-y · Cited by 13
Metadata
- Authors
- Misra, M., & Klibanski, A.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2014-06
- Volume
- 221
- Issue
- 3
- Pages
- R163-R176
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2167032038
- Cited by
- 171
- References
- 7
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Anorexia nervosa and bone. https://app.cochat.ai/papers/10.1530/joe-14-0039
- The paper
- Misra, M., & Klibanski, A. (2014). Anorexia nervosa and bone. Journal of Endocrinology. https://doi.org/10.1530/joe-14-0039
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
