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Qualitative and quantitative changes in protein synthesis occur at the 8–16-cell stage of embryogenesis in the cow
Abstract
Summary. Cow oocytes and preimplantation embryos were cultured in medium containing radiolabelled methionine and the proteins synthesized were analysed by one-dimensional electrophoresis and fluorography. Marked changes in the pattern of synthesis were observed at the 8–16-cell stage of development. Quantitatively, a gradual decrease in the rate of protein synthesis occurred between the zygote and 8-cell stage and then the rate increased progressively to the blastocyst stage. Incorporation of radiolabelled uridine into RNA was first detected at the 16-cell stage. Taken together, these results suggest that protein synthesis is programmed by maternal mRNA up to the 8-cell stage but switches to mRNA derived from the zygote genome between the 8- and 16-cell stage. Keywords: embryo; maternal mRNA; transcription; translation; cow
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Citations
Cited by
Effect of Persistent Follicles on Early Embryonic Losses in Beef Cows1
Ahmad, N., Neal Schrick, F., Butcher, R. L., & Keith Inskeep, E. (1995) · Biology of Reproduction · doi:10.1095/biolreprod52.5.1129 · Cited by 273
Hearn, J. P., Webley, G. E., & Gidley-Baird, A. A. (1991) · Reproduction · doi:10.1530/jrf.0.0920497 · Cited by 46
Metadata
- Authors
- Frei, R. E., Schultz, G. A., & Church, R. B.
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-07-01
- Volume
- 86
- Issue
- 2
- Pages
- 637-641
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W1998496693
- Cited by
- 240
- References
- 0
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frei, R. E., Schultz, G. A., & Church, R. B. (1989). Qualitative and quantitative changes in protein synthesis occur at the 8–16-cell stage of embryogenesis in the cow. Reproduction. https://doi.org/10.1530/jrf.0.0860637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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