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Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress

Bolnick, A. D., Abdulhasan, M. A., Kilburn, B. A., Xie, Y., Howard, M., Andresen, P., Shamir, A. M., Dai, J., Puscheck, E. E., Secor, E. R., et al. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-1028-x · Cited by 9 · see citing works

Diverse Roles of Metformin During Peri-Implantation Development: Revisiting Novel Molecular Mechanisms Underlying Clinical Implications

Banerjee, P., Bhonde, R. R., & Pal, R. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0171 · Cited by 8 · see citing works

Using Live Imaging and Fluorescence Ubiquitinated Cell Cycle Indicator Embryonic Stem Cells to Distinguish G1 Cell Cycle Delays for General Stressors like Perfluoro-Octanoic Acid and Hyperosmotic Sorbitol or G2 Cell Cycle Delay for Mutagenic Stressors like Benzo(a)pyrene

Abdulhasan, M. A., Ruden, X. L., Marben, T., Harris, S. M., Ruden, D. M., Awonuga, A. O., Puscheck, E. E., & Rappolee, D. A. (2022) · Stem Cells and Development · doi:10.1089/scd.2021.0330 · Cited by 8 · see citing works

A Single Cell Transcriptomic Fingerprint of Stressed Premature, Imbalanced Differentiation of Embryonic Stem Cells

Ruden, X. L., Singh, A., Marben, T., Tang, W., Awonuga, A. O., Ruden, D. M., Puscheck, E. E., Feng, H., Korzeniewski, S. J., & Rappolee, D. A. (2024) · Birth Defects Research · doi:10.1002/bdr2.2409 · Cited by 6 · see citing works

Novel high throughput screen reports that benzo(a)pyrene overrides mouse trophoblast stem cell multipotency, inducing SAPK activity, HAND1 and differentiated trophoblast giant cells

Kidder, B. L., Ruden, X. L., Singh, A., Marben, T., Rass, L. F. B., Chakravarty, A., Xie, Y. F., Puscheck, E. E., Awonuga, A. O., Harris, S. M., et al. (2024) · Placenta · doi:10.1016/j.placenta.2023.12.020 · Cited by 3 · see citing works

Novel kinetic and developmental transcriptomic pan-stress responses by embryonic stem cells

Singh, A., Ruden, X. L., Tang, W., Awonuga, A. O., Ruden, D. M., Korzeniewski, S. J., Puscheck, E. E., Feng, H., & Rappolee, D. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-06628-z · Cited by 1 · see citing works

Cell lineage choice during differentiation of trophoblast stem cells (tsc) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function

Zhou, S. (2011) · Human Biology

The role of Ankyrin repeat and SOCS box containing protein 4 (ASB4) in trophoblast differentiation and pseudovasculogenesis

Townley-Tilson, W. H. D. (2014)

AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function

Carey, E. A. K. (2013) · Journal of Bioresource Management

Identification Of Oxygen Optima For Mouse Trophoblast Stem Cells And Human Embryos And The Stress Responses Upon Departing Optima

Yang, Y. (2017) · Human Biology

Proximate And Evolutionary Insights Into The Epigenetics Of Posttraumatic Stress Disorder

Sipahi, L. (2014) · Human Biology

The integrated developmental stress response (ISR-DASR) shift reveals a functional transition from cellular to stem cell organismal adaptation

Ruden, X. L., Coddington, C., Asplund, L., Awonuga, A. O., Ruden, D. M., Korzeniewski, S. J., Zhang, L., Puscheck, E., & Rappolee, D. A. (2026) · Scientific Reports · doi:10.1038/s41598-026-55295-1

Hyperosmotic stress enzyme signaling modulates OCT4, NANOG, and REX1 expression and induces prioritized differentiation of murine embryonic stem cells

Slater, J. A. (2012) · Human Biology

Stress rapidly down regulates inhibitor of differentiation 2 in trophoblast stem cells via AMP activated Kinase-dependent pathway

Abdallah, M. E., Awonuga, A. O., Xie, Y., Puscheck, E. E., Daimond, M. P., & Rappolee, D. A. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.07.1583

Stress and Stress Enzymes Have Some Shared Functions in Pre-Implantation Embryos and Their Trophoblast Stem Cells.

Rappolee, D. A., Xie, Y., Slater, J. A., Zhou, S., Awonuga, A. O., Addallah, M., & Puscheck, E. E. (2009) · Biology of Reproduction · doi:10.1093/biolreprod/81.s1.666

IMPACT OF STRESS AND STRESS ENZYMES ON EARLY MAMMALIAN DEVELOPMENT

Rappolee, D. A. (2007) · Biology of Reproduction · doi:10.1093/biolreprod/77.s1.66b

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Zhong, W., Puscheck, E. E., Liu, J., Xie, Y., Wang, F., & Rappolee, D. A. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.216

Stress Induces AMPK-Dependent Loss of Potency Factors Id2 and Cdx2 in Early Embryos and Stem Cells

Xie, Y., Awonuga, A. O., Liu, J., Rings, E. H. H. M., Puscheck, E. E., & Rappolee, D. A. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0352 · Cited by 35 · see citing works