Cited by 34Prenatal Screening and DiagnosticsAssisted Reproductive Technology and Twin PregnancyReproductive Health and Technologies

PREIMPLANTATION GENETIC TESTING: clinical experience of preimplantation genetic testing

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De Rycke, Martine, Berckmoes, Veerle, De Vos, Anick, Van De Voorde, Stefanie, Verdyck, Pieter, Verpoest, Willem, Keymolen, Kathelijn·2020·Reproduction

Abstract

Thirty years of rapid technological advances in the field of genetic testing and assisted reproduction have reshaped the procedure of preimplantation genetic testing (PGT). The development of whole genome amplification and genome-wide testing tools together with the implementation of optimal hormonal stimulation protocols and more efficient cryopreservation methods have led to more accurate diagnoses and improved clinical outcomes. In addition, the shift towards embryo biopsy at day 5/6 has changed the timeline of a typical PGT clinical procedure. In this paper, we present an up-to-date overview of the different steps in PGT from patient referral to baby follow-up.

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  • Pre-implantation genetic testing is currently offered to women with recurrent pregnancy loss or repetitive implantation failure after in vitro fertilization procedures although the clinical benefit is an ongoing topic of discussion.

    “Pre-implantation genetic testing is currently offered to women with recurrent pregnancy loss or repetitive implantation failure after in vitro fertilization procedures although the clinical benefit is an ongoing topic of discussion.74,75”

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Authors
De Rycke, M., Berckmoes, V., De Vos, A., Van De Voorde, S., Verdyck, P., Verpoest, W., & Keymolen, K.
Affiliations
  • Centre for Medical Genetics , Universitair Ziekenhuis Brussel, Laarbeeklaan, Brussels, Belgium
  • Universitair Ziekenhuis Brussel (BE)
  • Centre for Reproductive Medicine , Universitair Ziekenhuis Brussel, Laarbeeklaan, Brussels, Belgium
Venue
Reproduction
Published
2020-11-01
Volume
160
Issue
5
Pages
A45-A58
ISSN
  • 1470-1626 (ISSN-L)
  • 1741-7899
OpenAlex
W3093062849
Cited by
34
References
80
Citations by year
2026: 3 · 2025: 4 · 2024: 13 · 2023: 7 · 2022: 5 · 2021: 2
FWCI
0.77
Type
journal article
Language
en
Open access
Locations
  • Reproduction (publishedVersion)
  • PubMed (publishedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
preimplantation genetic testing, assisted reproduction, whole genome amplification, embryo cryopreservation, referral, clinical outcomes, patient follow-up
MeSH terms
Chromosome Aberrations, Female, Fetal Diseases, Genetic Testing, Humans, Pregnancy, Preimplantation Diagnosis, Genetic Diseases, Inborn

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