The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
FSH and testosterone signaling in Sertoli cells
Open accessAbstract
Testosterone and follicle-stimulating hormone (FSH) are required to obtain full reproductive potential. In the testis, somatic Sertoli cells transduce signals from testosterone and FSH into the production of factors that are required by germ cells as they mature into spermatozoa. Recent advances in identifying new signaling pathways that are regulated by FSH and testosterone have allowed for refinement in the understanding of the independent, overlapping and synergistic actions of these hormones. In this review, we discuss the signaling pathways that are regulated by FSH and testosterone as well as the resulting metabolic and gene expression changes that occur as related to Sertoli cell proliferation, differentiation and the support of spermatogenesis.
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Citations
Cites
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions
Heinlein, C. A., & Chang, C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0070 · Cited by 568 · cited 1×
“…CREB transcription factor in Sertoli cells Increasing evidence has been gathered demonstrating that androgen can directly activate cellular signaling pathways by nongenomic pathways that are independent of AR binding to DNA (reviewed in Cato et al. 2002, Heinlein & Chang 2002, Silva et al. 2002).”
Background
Cited by
The testis in immune privilege
Fijak, M., & Meinhardt, A. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00438.x · Cited by 483
The Sertoli cell: one hundred fifty years of beauty and plasticity
França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C., & Griswold, M. D. (2016) · Andrology · doi:10.1111/andr.12165 · Cited by 419
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326
“In males, FSH and LH stimulate the production of testosterone, a hormone required for normal spermatogenesis (Huang et al., 2001; Walker and Cheng, 2005).”
BackgroundWalters, K. A., Simanainen, U., & Handelsman, D. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq003 · Cited by 183
Interplay Between Endocannabinoids, Steroids and Cytokines in the Control of Human Reproduction
Battista, N., Pasquariello, N., Di Tommaso, M., & Maccarrone, M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01684.x · Cited by 144
Metadata
- Authors
- Walker, W. H., & Cheng, J.
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-07-01
- Volume
- 130
- Issue
- 1
- Pages
- 15-28
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2021277982
- Cited by
- 467
- References
- 1
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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