The DOI matches its OpenAlex record; 7 of the 7 references it cites were found in a registry or an index.
Apoptosis in the human embryo
Open accessAbstract
Preimplantation human embryos are characterized by various degrees of cytoplasmic fragmentation, and a high incidence of developmental arrest before the blastocyst stage. This review examines the current morphological and biochemical evidence that apoptosis plays a role in early human development and embryonic loss. Embryos examined 24 h or more after arrest often show characteristic features of apoptosis including cytoplasmic, nuclear and DNA fragmentation. In contrast, embryos of good morphology that appear to be developing normally show no evidence of apoptosis before compaction. However, at the morula and blastocyst stages, scattered cells with fragmented nuclei and DNA characteristic of cells undergoing apoptosis are common features. Apoptosis may result from suboptimal culture conditions, or may be involved in the elimination of abnormal cells. However, the causes, role and regulation of apoptosis in the human preimplantation embryo remain to be determined.
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Citations
Cites
Cell Death: The Significance of Apoptosis
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International Review of Cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,162
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
Hardy, K., Handyside, A. H., & Winston, R. M. L. (1989) · Development · doi:10.1242/dev.107.3.597 · Cited by 553
Self-citationCell death in the mammalian blastocyst
Hardy, K. (1997) · Molecular Human Reproduction · doi:10.1093/molehr/3.10.919 · Cited by 338
Self-citationBiologic and morphologic development of donated human ova recovered by nonsurgical uterine lavage
Buster, J. E., Bustillo, M., Rodi, I. A., Cohen, S. W., Hamilton, M., Simon, J. A., Thorneycroft, I. H., & Marshall, J. R. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(85)90116-4 · Cited by 198
Comparative ultrastructure of hatched human, mouse and bovine blastocysts
Mohr, L. R., & Trounson, A. O. (1982) · Reproduction · doi:10.1530/jrf.0.0660499 · Cited by 86
Blerkom, J. V., & Davis, P. W. (1998) · Human Reproduction · doi:10.1093/humrep/13.5.1317 · Cited by 76
Cited by
Hussein, T. S., Froiland, D. A., Amato, F., Thompson, J. G., & Gilchrist, R. B. (2005) · Journal of Cell Science · doi:10.1242/jcs.02644 · Cited by 357
The actin cytoskeleton as a sensor and mediator of apoptosis
Desouza, M., Gunning, P. W., & Stehn, J. R. (2012) · BioArchitecture · doi:10.4161/bioa.20975 · Cited by 290
Metcalfe, A. D., Hunter, H. R., Bloor, D. J., Lieberman, B. A., Picton, H. M., Leese, H. J., Kimber, S. J., & Brison, D. R. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20055 · Cited by 104
Metadata
- Authors
- Hardy, K.
- Venue
- Reviews of Reproduction
- Publisher
- Bioscientifica
- Published
- 1999-09-01
- Volume
- 4
- Issue
- 3
- Pages
- 125-134
- ISSN
- 1359-6004 (ISSN-L)
- OpenAlex
- W2168902374
- Cited by
- 294
- References
- 7
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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