Bioinformatic-based identification of genes associated with aortic valve stenosis
Open accessAbstract
Background: Aortic valve stenosis (AS) disease is the most common valvular disease in developed countries. The pathology of AS is complex, and its main processes include calcification of the valve stroma and involve genetic factors, lipoprotein deposition and oxidation, chronic inflammation, osteogenic transition of cardiac valve interstitial cells, and active valve calcification. The aim of this study was to identify potential genes associated with AS. Methods: Three original gene expression profiles (GSE153555, GSE12644, and GSE51472) were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by GEO2R tool or ‘limma’ in R to identify differentially expressed genes (DEGs). Functional enrichment was analyzed using the ClusterProfiler package in R Bioconductor. STRING was utilized for the Protein–Protein Interaction (PPI) Network construct, and tissue-specific gene expression were identified using BioGPS database. The hub genes were screened out using the Cytoscape software. Related miRNAs were predicted in Targetscan, miWalk, miRDB, Hoctar, and TarBase. Results: A total of 58 upregulated genes and 20 downregulated genes were screened out, which were mostly enriched in matrix remodeling and the immune system process. A module was thus clustered into by PPI network analysis, which mainly involved in Fc gamma R-mediated phagocytosis, Osteoclast differentiation. Ten genes (IBSP, NCAM1, MMP9, FCGR3B, COL4A3, FCGR1A, THY1, RUNX2, ITGA4, and COL10A1) with the highest degree scores were subsequently identified as the hub genes for AS by applying the CytoHubba plugin. And hsa-miR-1276 was finally identified as potential miRNA and miRNA-gene regulatory network was constructed using NetworkAnalyst. Conclusions: Our analysis suggested that IBSP, NCAM1, MMP9, FCGR3B, COL4A3, FCGR1A, THY1, RUNX2, ITGA4, and COL10A1 might be hub genes associated with AS, and hsa-miR-1276 was potential miRNA. This result could provide novel insight into pathology and therapy of AS in the future.
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Many of the most differentially expressed genes in severe forms of CAVS were previously reported in smaller studies.
“As expected, many of the most differentially expressed genes in severe forms of CAVS were previously reported in smaller studies (PDK4, BTG2, SLC16A9, GPR68, FAP, CNTFR, PLEKHS1, THY1, SCG2, CXCL5, TNC, TDO2, LINC01614).9,12,13,28, 29, 30, 31, 32, 33”
From Transcriptomic signatures of calcific aortic valve stenosis severity in human tricuspid and bicuspid aortic valves (2025) · cites this paper as [28]
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Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works
Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., Simonovic, M., Doncheva, N. T., Morris, J. H., Bork, P., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1131 · Cited by 17,749 · see citing works
NCBI GEO: archive for functional genomics data sets—update
Barrett, T., Wilhite, S. E., Ledoux, P., Evangelista, C., Kim, I. F., Tomashevsky, M., Marshall, K. A., Phillippy, K. H., Sherman, P. M., Holko, M., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1193 · Cited by 10,418 · see citing works
Burden of valvular heart diseases: a population-based study
Nkomo, V. T., Gardin, J. M., Skelton, T. N., Gottdiener, J. S., Scott, C. G., & Enriquez-Sarano, M. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69208-8 · Cited by 4,881 · see citing works
Iung, B. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00201-x · Cited by 3,530 · see citing works
Nishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Fleisher, L. A., Jneid, H. M., Mack, M. J., McLeod, C. J., O’Gara, P. T., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000503 · Cited by 2,506 · see citing works
Zhou, G., Soufan, O., Ewald, J., Hancock, R. E. W., Basu, N., & Xia, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz240 · Cited by 1,894 · see citing works
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509 · see citing works
Otto, C. M., Kuusisto, J., Reichenbach, D. D., Gown, A. M., & O’Brien, K. D. (1994) · Circulation · doi:10.1161/01.cir.90.2.844 · Cited by 1,315 · see citing works
Proinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094 · see citing works
Yadgir, S., Johnson, C. O., Aboyans, V., Adebayo, O., Adedoyin, R. A., Afarideh, M., Alahdab, F., Alashi, A., Alipour, V., Arabloo, J., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043391 · Cited by 496 · see citing works
Aikawa, E. R., Nahrendorf, M., Sosnovik, D. E., Lok, V. M., Jaffer, F. A., Aikawa, M., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.106.654913 · Cited by 419 · see citing works
Caira, F. C., Stock, S. R., Gleason, T. G., McGee, E. C., Huang, J., Bonow, R. O., Spelsberg, T. C., McCarthy, P. M., Rahimtoola, S. H., & Rajamannan, N. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.040 · Cited by 371 · see citing works
Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms
Miller, J. D., Weiss, R. M., & Heistad, D. D. (2011) · Circulation Research · doi:10.1161/circresaha.110.234138 · Cited by 321 · see citing works
Schlotter, F., Halu, A., Goto, S., Blaser, M. C., Body, S. C., Lee, L. H., Higashi, H., DeLaughter, D. M., Hutcheson, J. D., Vyas, P., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.032291 · Cited by 256 · see citing works
NFATc1: Functions in osteoclasts
Zhao, Q., Wang, X., Liu, Y., He, A., & Jia, R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.12.018 · Cited by 238 · see citing works
Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease
Coté, N., Mahmut, A., Bosse, Y., Couture, C., Pagé, S., Trahan, S., Boulanger, M.-C., Fournier, D., Pibarot, P., & Mathieu, P. (2013) · Inflammation · doi:10.1007/s10753-012-9579-6 · Cited by 218 · see citing works
Touchberry, C., Green, T. M., Tchikrizov, V., Mannix, J., Mao, T. F., Carney, B. W., Girgis, M., Vincent, R. J., Wetmore, L. A., Dawn, B., et al. (2013) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00596.2012 · Cited by 195 · see citing works
Bossé, Y., Miqdad, A., Fournier, D., Pépin, A., Pibarot, P., & Mathieu, P. (2009) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.108.820795 · Cited by 148 · see citing works
Ghaisas, N., Foley, J. B., O'Briain, D. S., Crean, P., Kelleher, D., & Walsh, M. J. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00998-0 · Cited by 143 · see citing works
Thériault, S., Gaudreault, N., Lamontagne, M., Rosa, M., Boulanger, M.-C., Messika-Zeitoun, D., Clavel, M.-A., Capoulade, R., Dagenais, F., Pibarot, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03260-6 · Cited by 135 · see citing works
Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart
Soini, Y., Satta, J., M��tt�, M., & Autio‐Harmainen, H. (2001) · The Journal of Pathology · doi:10.1002/path.850 · Cited by 128 · see citing works
Nagy, E., Andersson, D. C., Caidahl, K., Eriksson, M. J., Eriksson, P. O., Franco‐Cereceda, A., Hansson, G. K., & Bäck, M. (2011) · Circulation · doi:10.1161/circulationaha.110.966846 · Cited by 112 · see citing works
Development of calcific aortic valve disease: Do we know enough for new clinical trials?
Kostyunin, A. E., Yuzhalin, A. E., Ovcharenko, E. A., & Кутихин, А. Г. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.016 · Cited by 95 · see citing works
Gharibeh, L., Komati, H., Bossé, Y., Boodhwani, M., Heydarpour, M., Fortier, M., Hassanzadeh, R., Ngu, J. M. C., Mathieu, P., Body, S. C., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.029506 · Cited by 94 · see citing works
GOMEZ, A. P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.7 · Cited by 85 · see citing works
Stritzke, J., Linsel‐Nitschke, P., Markus, M. R. P., Mayer, B., Lieb, W., Luchner, A., Döring, A., Köenig, W., Keil, U., Hense, H. W., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp287 · Cited by 82 · see citing works
Guauque-Olarte, S., Droit, A., Tremblay-Marchand, J., Gaudreault, N., Kalavrouziotis, D., Dagenais, F., Seidman, J. G., Body, S. C., Pibarot, P., Mathieu, P., et al. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00041.2016 · Cited by 82 · see citing works
Ghosh, S., Vivar, J. C., Nelson, C. P., Willenborg, C., Segrè, A. V., Mäkinen, V., Nikpay, M., Erdmann, J., Blankenberg, S., O’Donnell, C. J., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305513 · Cited by 79 · see citing works
Olesen, P., Nguyen, K., Wogensen, L., Ledet, T., & Rasmussen, L. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00047.2006 · Cited by 75 · see citing works
The Human Bone Sialoprotein Gene (IBSP): Genomic Localization and Characterization
Kerr, J. M., Fisher, L. W., Termine, J. D., Wang, M. G., McBride, O. W., & Young, M. F. (1993) · Genomics · doi:10.1006/geno.1993.1340 · Cited by 74 · see citing works
Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway
Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L. M., Methawasin, M., Lee, D. I., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.02.074 · Cited by 60 · see citing works
Genetic Variation in NCAM1 Contributes to Left Ventricular Wall Thickness in Hypertensive Families
Arnett, D. K., Meyers, K. J., Devereux, R. B., Tiwari, H. K., Gu, C. C., Vaughan, L. K., Perry, R. T., Patki, A., Claas, S. A., Sun, Y. V., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.239210 · Cited by 55 · see citing works
Kostyunin, A. E., Mukhamadiyarov, R. А., Glushkova, T. V., Bogdanov, L. A., Shishkova, D. K., Osyaev, N. Y., Ovcharenko, E. A., & Кутихин, А. Г. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207434 · Cited by 50 · see citing works
Hewing, B., Au, S. C.-D., Ludwig, A., Ellerbroek, R., van Dijck, P., Hartmann, L., Grubitzsch, H., Giannini, C., Laule, M., Stangl, V., et al. (2017) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9726-9 · Cited by 49 · see citing works
Calcific Aortic Valve Stenosis and Atherosclerotic Calcification
Sá, M. P., Cavalcanti, L. R. P., Perazzo, Á., Gomes, R. A. F., Clavel, M.-A. A., Pîbarot, P., Biondi‐Zoccai, G., Zhigalov, K., Weymann, A., Ruhparwar, A., et al. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-0821-7 · Cited by 47 · see citing works
Wu, H. D., Maurer, M. S., Friedman, R. A., Marboe, C. C., Ruiz-Vazquez, E. M., Ramakrishnan, R., Schwartz, A. J., Tilson, M. D., Stewart, A. S., & WINCHESTER, R. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5329 · Cited by 45 · see citing works
Pasipoularides, A. D. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9679-z · Cited by 45 · see citing works
Aortic stenosis: insights on pathogenesis and clinical implications.
Carità, P., Coppola, G., Novo, G., Caccamo, G., Guglielmo, M., Balasus, F., Novo, S., Castrovinci, S., Moscarelli, M., Fattouch, K., et al. (2016) · PubMed Central · doi:10.11909/j.issn.1671-5411.2016.06.001 · Cited by 45 · see citing works
Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation
Pohjolainen, V., Taskinen, P., Soini, Y., Rysä, J., Ilves, M., Juvonen, T. S., Ruskoaho, H. J., Leskinen, H. K., & Satta, J. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.04.015 · Cited by 43 · see citing works
Comparative transcriptome profiling in human bicuspid aortic valve disease using RNA sequencing
Padang, R., Bagnall, R. D., Tsoutsman, T., Bannon, P. G., & Semsarian, C. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00115.2014 · Cited by 39 · see citing works
Diagnosis and Management of Aortic Valve Stenosis in Patients with Heart Failure
Kamperidis, V., Delgado, V., Mieghem, N. M. V., Kappetein, A. P., Leon, M. B., & Bax, J. J. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.466 · Cited by 37 · see citing works
Ferreira, S. A., Young, G. R., Jones, J. R., & Rankin, S. M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111393 · Cited by 37 · see citing works
Frailty is associated with chronic inflammation and pro-inflammatory monocyte subpopulations
Cybularz, M., Wydra, S., Berndt, K., Poitz, D. M., Barthel, P., Alkouri, A., Heidrich, F. M., Ibrahim, K. S., Jellinghaus, S., Speiser, U., et al. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111317 · Cited by 33 · see citing works
BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
Gambardella, L., McManus, S. A., Moignard, V., Sebukhan, D., Delaune, A., Andrews, S., Bernard, W. G., Morrison, M. A., Riley, P. R., Göttgens, B., et al. (2019) · Development · doi:10.1242/dev.174441 · Cited by 31 · see citing works
Ibarrola, J., Sádaba, R., Martínez‐Martínez, E., García-Peña, A., Arrieta, V., Álvarez, V., Fernández‐Celis, A., Gainza, A., Cachofeiro, V., Santamaría, E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25068-6 · Cited by 30 · see citing works
Transcriptional profiling of normal, stenotic, and regurgitant human aortic valves
Greene, C. L., Jaatinen, K. J., Wang, H., Koyano, T. K., Bilbao, M. S., & Woo, Y. J. (2020) · Genes · doi:10.3390/genes11070789 · Cited by 30 · see citing works
The 140-kD Isoform of CD56 (NCAM1) Directs the Molecular Pathogenesis of Ischemic Cardiomyopathy
Tur, M. K., Etschmann, B., Benz, A., Leich, E., Waller, C., Schuh, K., Rosenwald, A., Ertl, G., Kienitz, A., ten Haaf, A., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.027 · Cited by 28 · see citing works
Berndt, K., Wydra, S., Tarnowski, D., Barthel, P., Quick, S., Ulbrich, S., Christoph, M., Waessnig, N. K., Speiser, U., Wunderlich, C., et al. (2016) · Thrombosis and Haemostasis · doi:10.1160/th15-06-0477 · Cited by 27 · see citing works
Alkaptonuria-Associated Aortic Stenosis
Lok, Z. S. Y., Goldstein, J., & Smith, J. A. (2013) · Journal of Cardiac Surgery · doi:10.1111/jocs.12129 · Cited by 24 · see citing works
Mazur, P. K., Mielimonka, A., Natorska, J., Wypasek, E., Gawęda, B., Sobczyk, D., Kapusta, P., Malinowski, K. P., & Kapelak, B. (2018) · Cardiovascular Pathology · doi:10.1016/j.carpath.2018.03.004 · Cited by 24 · see citing works
Choice of Valve Prosthesis in a Rare Clinical Condition: Aortic Stenosis due to Alkaptonuria
Thakur, S., Markman, P. L., & Cullen, H. C. (2013) · Heart Lung and Circulation · doi:10.1016/j.hlc.2012.12.015 · Cited by 22 · see citing works
Hewing, B., Ellerbroek, R., Au, S. C.-D., Stangl, V., Dreger, H., Laule, M., Grubitzsch, H., Knebel, F., Baumann, G., Ludwig, A., et al. (2017) · Thrombosis and Haemostasis · doi:10.1160/th17-05-0341 · Cited by 20 · see citing works
Hypoxia Stimulates Synthesis of Neutrophil Gelatinase-Associated Lipocalin in Aortic Valve Disease
Swaminathan, G., Krishnamurthy, V. K., Sridhar, S., Robson, D. C., Ning, Y., & Grande-Allen, K. J. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00156 · Cited by 20 · see citing works
Sun, J.-Y., Yang, H., Shen, H., Qu, Q., Kan, J., Kong, X., Sun, W., & Shen, Y.-Y. (2021) · BMC Medical Genomics · doi:10.1186/s12920-021-00989-w · Cited by 20 · see citing works
Current Progress in Bioinformatics 2016
Altman, R. B. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv105 · Cited by 19 · see citing works
Identification of key genes in calcific aortic valve disease by integrated bioinformatics analysis
Teng, P., Xu, X., Ni, C., Yan, H., Sun, Q., Zhang, E., & Ni, Y. (2020) · Medicine · doi:10.1097/md.0000000000021286 · Cited by 17 · see citing works
Ochronosis of Mitral Valve and Coronary Arteries
Gottschalk, B. H., Blankenstein, J., & Guo, L.-R. R. (2018) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2018.01.074 · Cited by 15 · see citing works
Wasywich, C. A., Webster, M. W. I., Richards, M., & Stewart, R. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.10.048 · Cited by 14 · see citing works
Ma, F., Li, T., Zhang, H.-J., & Wu, G.-J. (2016) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000419 · Cited by 13 · see citing works
Sen, J., Chung, E., Neil, C., & Marwick, T. H. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-036960 · Cited by 13 · see citing works
Pfluecke, C., Wydra, S., Berndt, K., Tarnowski, D., Cybularz, M., Jellinghaus, S., Mierke, J., Ende, G., Poitz, D. M., Barthel, P., et al. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.05.030 · Cited by 12 · see citing works
Extended bioreactor conditioning of mononuclear cell–seeded heart valve scaffolds
VeDepo, M. C., Buse, E. E., Quinn, R. W., Hopkins, R. A., & Converse, G. L. (2018) · Journal of Tissue Engineering · doi:10.1177/2041731418767216 · Cited by 9 · see citing works
Fan, X., Peng, J., Lei, L., He, J., Huang, J., Zheng, D., Xu, W., Cai, S., & Chen, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.03.05 · Cited by 9 · see citing works
An interesting Mybpc3 heterozygous mutation associated with bicuspid aortic valve
Xiaopei, Z., Hou, C., Xiao, T., Xie, L., Li, Y., Jia, J., Zheng, J., Zhang, Y., & Xu, M. (2020) · Translational Pediatrics · doi:10.21037/tp-20-81 · Cited by 7 · see citing works
Molecular recognition of aortic valve stenosis and regurgitation.
Urban, P., Rabajdová, M., Špaková, I., Sabol, F., Mičková, H., Lakatosová, K., & Závacká, M. (2019) · PubMed · doi:10.26355/eurrev_201912_19805 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Research works printed but not linked: 12
- Bossé Y, Mathieu P, Pibarot P. 2008. Genomics: the next step to elu- cidate the etiology of calcific aortic valve stenosis. J Am Coll Cardiol. 51(14):1327-1336.
- Carabello BA, Paulus WJ. 2009. Aortic stenosis. Lancet. 373(9667):956-966.
- Coffey S, Cox B, Williams MJ. 2014. The prevalence, incidence, pro- gression, and risks of aortic valve sclerosis: a systematic review and meta- analysis. J Am Coll Cardiol. 63(25 Pt A):2852-2861.
- Cui L, Rashdan NA, Zhu D, Milne EM, Ajuh P, Milne G, et al. 2017. Bioinformatic-based Identification of Genes Associated with Aortic Valve Stenosis -Song et al E77 © 2022 Forum Multimedia Publishing, LLC End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived- matrix vesicles. J Cell Physiol. 232(11):2985-2995.
- Fang M, Alfieri CM, Hulin A, Conway SJ, Yutzey KE. 2014. Loss of β-catenin promotes chondrogenic differentiation of aortic valve intersti- tial cells. Arterioscler Thromb Vasc Biol. 34(12):2601-2608.
- George J, Afek A, Gilburd B, Blank M, Levy Y, Aron-Maor A, et al. 1998. Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I. Circulation. 98(11):1108-1115.
- Goody PR, Hosen MR, Christmann D, Niepmann ST, Zietzer A, Adam M, et al. 2020. Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets. Arterioscler Thromb Vasc Biol. 40(4):885-900.
- Hadji F, Boulanger MC, Guay SP, Gaudreault N, Amellah S, Mkannez G, et al. 2016. Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1. Circulation. 134(23):1848-1862.
- Lok ZS, Goldstein J, Smith JA. 2013. Alkaptonuria-associated aortic ste- nosis. J Card Surg. 28(4):417-420.
- O', Brien KD. 2006. Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more). Arterioscler Thromb Vasc Biol. 26(8):1721-1728.
- Shao JS, Cai J, Towler DA. 2006. Molecular mechanisms of vascular cal- cification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol. 26(7):1423-1430.
- Zhao Q, Wang X, Liu Y, He A, Jia R. 2010. NFATc1: functions in osteo- clasts. Int J Biochem Cell Biol. 42(5):576-579.
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Mo, Q., Zhan, A., Bai, R., Lin, S., Feng, J., Li, T., Lao, Z., Yang, X. Q., Wang, K., Rong, X., et al. (2025) · PeerJ · doi:10.7717/peerj.19040
- Authors
- Song, C., Wei, S., Fan, Y., & Jiang, S.
- Affiliations
- Chinese PLA General Hospital (CN)
- Venue
- The Heart Surgery Forum
- Publisher
- IMR Press
- Published
- 2022-01-24
- Volume
- 25
- Issue
- 1
- Pages
- E069-E078
- ISSN
- 1098-3511 (ISSN-L)
- 1522-6662
- OpenAlex
- W4206939975
- Cited by
- 5
- References
- 68
- Citations by year
- 2025: 4 · 2022: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Heart Surgery Forum (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- aortic stenosis, valve calcification, differentially expressed genes, hub genes, protein-protein interaction network, microRNA, miRNA-gene regulatory network, osteoclastogenesis, matrix remodeling, immune system process, bone sialoprotein, CD56, MMP-9, COL4A3, COL10A1, Runx2, CD49d
- MeSH terms
- Aortic Valve Stenosis, Humans, Gene Expression Regulation, Neoplastic, Computational Biology, Gene Expression Profiling, Gene Regulatory Networks
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