Cited by 186Genetic diversity and population structureEvolution and Genetic DynamicsGenetic Mapping and Diversity in Plants and Animals

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Testing for Spatially Divergent Selection: Comparing Q ST to F ST

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Whitlock, Michael C, Guillaume, Frederic·2009·Genetics

DOI 10.1534/genetics.108.099812PMC PMC2778959

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Abstract

Q(ST) is a standardized measure of the genetic differentiation of a quantitative trait among populations. The distribution of Q(ST)'s for neutral traits can be predicted from the F(ST) for neutral marker loci. To test for the neutral differentiation of a quantitative trait among populations, it is necessary to ask whether the Q(ST) of that trait is in the tail of the probability distribution of neutral traits. This neutral distribution can be estimated using the Lewontin-Krakauer distribution and the F(ST) from a relatively small number of marker loci. We develop a simulation method to test whether the Q(ST) of a given trait is consistent with the null hypothesis of selective neutrality over space. The method is most powerful with small mean F(ST), strong selection, and a large number (>10) of measured populations. The power and type I error rate of the new method are far superior to the traditional method of comparing Q(ST) and F(ST).

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Authors: Whitlock, M. C., & Guillaume, F.
Affiliations: University of British Columbia (CA)
Department of Zoology , University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Corresponding author: Whitlock, Michael C
ORCID: Whitlock, Michael C
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 2009-11-01
Volume: 183
Issue: 3
Pages: 1055-1063
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1534/genetics.108.099812
PMC: PMC2778959
OpenAlex: W2131395947
Cited by: 180
References: 22
Citations by year: 2026: 4 · 2025: 9 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 10 · 2020: 14 · 2019: 15 · 2018: 21 · 2017: 6 · 2016: 15 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 12
FWCI: 5.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (115383)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: quantitative sensory testing, FST, type I error rate, statistical power, population genetics
MeSH terms: Algorithms, Animals, Computer Simulation, Genetics, Population, Humans, Models, Genetic, Selection, Genetic, Genetic Variation, Reproducibility of Results, Quantitative Trait, Heritable, Quantitative Trait Loci

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Testing for Spatially Divergent Selection: Comparing Q ST to F ST

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