The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
PHF24 is expressed in the inhibitory interneurons in rats
Open accessAbstract
Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in intron 2 of the PHD finger protein 24 (Phf24) gene, encoding Gαi-interacting protein (GINIP). Phf24 is a strong candidate gene for epileptogenesis in NER. PHF24 modulates GABAB signaling through interacting with Gαi protein. To clarify the epileptogenesis of NER, we investigated a distribution of PHF24-expressing cells in the central nerve system (CNS). While broad expression of PHF24 was observed in the CNS, characteristic expression was noted in the periglomerular layer of the olfactory bulb and the lamina II of the spinal cord in the control rats. These cells showed co-expression with calbindin or calretinin, inhibitory interneuron markers. In the olfactory bulb, 15.6% and 41.2% of PHF24-positive neurons co-expressed calbindin and calretinin, respectively. Immunoelectron microscopy revealed that PHF24 was located in the presynaptic terminals, synaptic membranes and cytoplasmic matrix of neuronal soma. Our data suggested PHF24 is expressed in the inhibitory interneurons and may play important roles in modulation of the GABAB signaling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PHF24 is a modulator of GABAB receptor activity.
“PHF24 is a modulator of GABAB receptor activity86”
From Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements (2023) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sakaba, T., & Neher, E. (2003) · Nature · doi:10.1038/nature01859 · Cited by 260
Dormancy of Inhibitory Interneurons in a Model of Temporal Lobe Epilepsy
Bekenstein, J. W., & Lothman, E. W. (1993) · Science · doi:10.1126/science.8093417 · Cited by 231
Ren, K., & Ruda, M. A. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90010-8 · Cited by 186
Kumar, S. S., & Buckmaster, P. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0064-06.2006 · Cited by 182
ROGERS, J. H. (1992) · Brain Research · doi:10.1016/0006-8993(92)90998-o · Cited by 164
Mangan, P. S., & Lothman, E. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.2.1282 · Cited by 94
Gaillard, S., Re, L. L., Mantilleri, A., Hepp, R., Urien, L., Malapert, P., Alonso, S., Deage, M., Kambrun, C., Landry, M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.056 · Cited by 69
NER Rat Strain: A New Type of Genetic Model in Epilepsy Research
Noda, A., Hashizume, R., Maihara, T., et al. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01281.x · Cited by 47
Localization and developmental expression of GABAB receptors in the rat olfactory bulb
Panzanelli, P., López‐Bendito, G., Luján, R., & Sassoé‐Pognetto, M. (2004) · Journal of Neurocytology · doi:10.1023/b:neur.0000029650.28943.b2 · Cited by 31
Nguyen, M. Q., & Ryba, N. J. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041899 · Cited by 23
Regional expression of Fos-like immunoreactivity following seizures in Noda epileptic rat (NER)
Ohno, Y., Shimizu, S., Harada, Y., Morishita, M., Ishihara, S., Kumafuji, K., Sasa, M., & Serikawa, T. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.07.012 · Cited by 22
Self-citationSerikawa, T., Kunisawa, N., Shimizu, S., Kato, M., Iha, H. A., Kinboshi, M., Nishikawa, H., Shirakawa, Y., Voigt, B., Nakanishi, S., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111922 · Cited by 20
Self-citationChromosomal Mapping of Genes for Epilepsy in NER: A Rat Strain with Tonic‐Clonic Seizures
Maihara, T., Noda, A., Yamazoe, H., Voigt, B., Kitada, K., & Serikawa, T. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00276.x · Cited by 19
Self-citationLiu, Z., Wang, F., Fischer, G. J., Hogan, Q. H., & Yu, H. (2016) · Molecular Pain · doi:10.1177/1744806916646380 · Cited by 19
Figueres‐Oñate, M., & López‐Mascaraque, L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00194 · Cited by 19
Restrepo, D., Hellier, J. L., & Salcedo, E. E. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.08.036 · Cited by 17
Kiura, Y., Hanaya, R., Serikawa, T., et al. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.137 · Cited by 13
Self-citationEnhanced Susceptibility to Spontaneous Seizures of Noda Epileptic Rats by Loss of Synaptic Zn2+
Takeda, A., Iida, M., Ando, M., Nakamura, M., Tamano, H., & Oku, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071372 · Cited by 13
Identification of Candidate Genes for Generalized Tonic–Clonic Seizures in Noda Epileptic Rat
Kuramoto, T., Voigt, B., Nakanishi, S., Kitada, K., Nakamura, T., Wakamatsu, K., Yoshihara, M., Suyama, M., Uemura, R., Tanaka, M., et al. (2017) · Behavior Genetics · doi:10.1007/s10519-017-9870-2 · Cited by 12
Self-citationThe usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics
Fujiwara, A., Watanabe, Y., Takechi, K., et al. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02378.x · Cited by 9
Flagged first, then by citations
Research works printed but not linked: 1
- 19. Fioretti AB, Fusetti M, Eibenstein A. The Predictive Role of Hyposmia in Alzheimer’s Disease. 2011. pp. 259–278. In: The Clinical Spectrum of Alzheimer’s Disease -The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies. (de la Monte S.M. eds.), INTECH, Rijeka.
Cited by
Sorted by citations
Anderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82
Metadata
- Authors
- Numakura, Y., Uemura, R., Tanaka, M., Izawa, T., Yamate, J., Kuramoto, T., Kaneko, T., Mashimo, T., Yamamoto, T., Serikawa, T., & Kuwamura, M.
- Affiliations
- Osaka Prefecture University (JP)
- Tokyo University of Agriculture (JP)
- Iwate University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Hiroshima University (JP)
- Kyoto University (JP)
- ORCID
- Venue
- Experimental Animals
- Published
- 2021
- Volume
- 70
- Issue
- 1
- Pages
- 137-143
- ISSN
- 0007-5124 (ISSN-L)
- 1341-1357
- 1881-7122
- PMC
- PMC7887615
- OpenAlex
- W3095036280
- Cited by
- 5
- References
- 20
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- EXPERIMENTAL ANIMALS (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (18H03974, 18KK0307)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- inhibitory interneurons, epileptogenesis, Gi protein, olfactory bulb, calbindin, calretinin, presynaptic terminals
- MeSH terms
- Animals, Central Nervous System, Disease Models, Animal, gamma-Aminobutyric Acid, Immunohistochemistry, Interneurons, Olfactory Bulb, Rats, Inbred F344, Seizures, Spinal Cord, Signal Transduction, Gene Expression, Homeodomain Proteins, Intracellular Signaling Peptides and Proteins, Rats, Genetic Association Studies, Calbindins, Calbindin 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
