A Cross‐Sectional Study on the Relationship of Job Stress with Natural Killer Cell Activity and Natural Killer Cell Subsets among Healthy Nurses
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A Cross‐Sectional Study on the Relationship of Job Stress with Natural Killer Cell Activity and Natural Killer Cell Subsets among Healthy Nurses: Yuko Morikawa, et al. Department of Public Health, Kanazawa Medical University— The present study investigated the effects of job stress on cellular immune function, such as NK cell activity and NK cell subsets. The participants were 61 female nurses aged 23–59, who worked in a public psychiatric hospital in Ishikawa, Japan. Each subject completed the Nursing Job Stressor Scale (NJSS) and their NK cell activity and lymphocyte surface antigens (CD16+56+) were evaluated as immune system parameters. The NJSS has seven subscales: conflict with other nursing staff, nursing role conflict, conflict with physicians or autonomy, conflict with death or dying, quantitative work load, qualitative work load and conflict with patients. Factors influencing NK cell activity, and the proportion and cell counts of CD16+56+ lymphocytes were evaluated. Increase in quantitative work load significantly decreased NK cell activity. Conversely, no linear relationship was observed between qualitative work load and immunological variables, with the highest percentage of CD16+56+ lymphocytes observed among participants in the medium work load group. The other five NJSS subscales did not relate to immune parameters. In conclusion, the results suggest that perceived job strains, particularly quantitative work load, decreased NK cell function.
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Comprehensive immune profiling in ME/CFS patients confirmed elevated TGF-β levels and lower resistin levels, and 17 cytokines, most of them pro-inflammatory, correlated with symptom severity.
“With the use of a comprehensive immune profiling approach in ME/CSF patients, elevated TGF-β levels were confirmed, in addition to findings of lower resistin levels (390), a protein participating in the inflammatory response and able to activate TNF in monocytes and macrophages (for review, see Ref. 187). In the same study, 17 cytokines, most of them pro-inflammatory, correlated with symptom sever”
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- Authors
- Morikawa, Y., Kitaoka‐Higashiguchi, K., Tanimoto, C., Hayashi, M., Oketani, R., Miura, K., Nishijo, M., & Nakagawa, H.
- Affiliations
- Kanazawa Medical University (JP)
- Ishikawa Prefectural Nursing University (JP)
- Ishikawa Prefectural Takamatsu Hospital (JP)
- Corresponding author
- Morikawa, Yuko
- Venue
- Journal of Occupational Health
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09
- Volume
- 47
- Issue
- 5
- Pages
- 378-383
- ISSN
- 1341-9145 (ISSN-L)
- 1348-9585
- OpenAlex
- W1966464185
- Cited by
- 51
- References
- 23
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Occupational Health (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (14570362)
- Topics
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Burnout
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- occupational stress, natural killer cells, NK cell subsets, cellular immune function, nurses, job strain, psychiatric nursing
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Humans, Japan, Killer Cells, Natural, Lymphocytes, Middle Aged, Nurses, Surveys and Questionnaires, Stress, Psychological, Workload, Receptors, IgG
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