The DOI matches its Crossref record.
CONGENITAL ANOMALIES IN THE RAT PRODUCED BY EXCESSIVE INTAKE OF VITAMIN A DURING PREGNANCY
Abstract
Excessive intake of vitamin A during pregnancy in the rat results in a marked litter failure. However, when litters are carried to term a variety of gross congenital anomalies are produced which include: encephaly, eye malformations, cleft palate, shortening of the mandible and maxilla, spina bifida with meningocele and hydrocephalus. Of 148 offspring of vitamin A-fed maternal rats, 77 exhibited gross malformations (an anomaly rate of 52%). There were no congenital anomalies observed in 1201 control young. The 7th to 10th day of gestation was found to be the period critically susceptible to the teratogenic effect of vitamin A excess. The stage specificity of various environmental agents and the possible mechanism of action of the teratogenic effect of maternal vitamin A excess are discussed.
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Cited by
Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942
Teratogenicity of high vitamin A intake
Rothman, K. J., Moore, L. L., Singer, M. R., Nguyen, U.-S. D. T., Mannino, S., & Milunsky, A. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332101 · Cited by 754
EMBRYOLOGICAL CONSIDERATIONS IN TERATOLOGY*
Wilson, J. G. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb12260.x · Cited by 438
Collins, M. D., & Mao, G. E. (1999) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.399 · Cited by 288
Hypervitaminosis A Induced Teratogenesis
Geelen, J. A. G., & Peters, P. W. J. (1979) · CRC Critical Reviews in Toxicology · doi:10.3109/10408447909043651 · Cited by 256
Metadata
- Authors
- COHLAN, S. Q.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1954-06-01
- Volume
- 13
- Issue
- 6
- Pages
- 556-567
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1638458828
- Cited by
- 211
- References
- 0
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CONGENITAL ANOMALIES IN THE RAT PRODUCED BY EXCESSIVE INTAKE OF VITAMIN A DURING PREGNANCY. https://app.cochat.ai/papers/10.1542/peds.13.6.556
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- COHLAN, S. Q. (1954). CONGENITAL ANOMALIES IN THE RAT PRODUCED BY EXCESSIVE INTAKE OF VITAMIN A DURING PREGNANCY. Pediatrics. https://doi.org/10.1542/peds.13.6.556
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