Observations on the endometrium and ovary in the newborn
Abstract
Post-mortem examination of endometria of 169 newborn infants reveals that 68 per cent are in an indifferent or proliferative phase, 27 per cent show secretory activity, and 5 per cent show progestational changes including decidual transformation of the stroma and changes analogous to those seen in adult menstruation. Examination of the ovaries in 115 of these cases shows gonadotropic changes in 38 per cent. Examination of the 42 adequately sectioned ovaries from this group plus 31 from cases in which the endometrium was not available shows gonadotropic activity in 90 per cent. The observation of atretic follicles indicates that cellular response to gonadotropic stimuli is present and occasionally completed in utero. It is concluded that the endometrial and ovarian changes are unrelated and that each is secondary to a different endocrine stimulus. Evidence is adduced to indicate that progesterone is capable of traversing the "Arthus' phenomenon" thereby producing a were infective hyperplasia of the spleen, placental membrane and producing the decidual transformation of the endometrial stroma.
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Partial or complete progesterone resistance is identified in over 66% of neonatal endometrial biopsies, while full response to progesterone is observed in around 33%.
“partial or complete progesterone resistance was identified in over 66% of cases in neonatal endometrium [24], while a full response to progesterone was observed in around 33% [24].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [24]
In 95% of neonates the endometrium responds with weak proliferation or secretory changes despite high maternal P levels during pregnancy.
“In 95% of the neonates, however, the endometrium responds with weak proliferation or secretory changes despite the high maternal P levels during pregnancy.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [23]
In 5% of neonates the endometrium is P responsive and responds with decidualization and menstrual changes.
“In a classic autopsy study of the neonatal endometrium the Harvard pathologists Ober and Bernstein (23) described that in 5% of the neonates the endometrium is P responsive and responds with decidualization and menstrual changes.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [23]
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Additional file 4 of Is neonatal uterine bleeding responsible for early-onset endometriosis?
Ogawa, K., Khan, K. N., Kuroboshi, H., Koshiba, A., Shimura, K., Tajiri, T., Fumino, S., Fujita, H., Okubo, T., Fujiwara, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26598161
Additional file 3 of Is neonatal uterine bleeding responsible for early-onset endometriosis?
Ogawa, K., Khan, K. N., Kuroboshi, H., Koshiba, A., Shimura, K., Tajiri, T., Fumino, S., Fujita, H., Okubo, T., Fujiwara, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26598158
Additional file 2 of Is neonatal uterine bleeding responsible for early-onset endometriosis?
Ogawa, K., Khan, K. N., Kuroboshi, H., Koshiba, A., Shimura, K., Tajiri, T., Fumino, S., Fujita, H., Okubo, T., Fujiwara, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26598155
Additional file 1 of Is neonatal uterine bleeding responsible for early-onset endometriosis?
Ogawa, K., Khan, K. N., Kuroboshi, H., Koshiba, A., Shimura, K., Tajiri, T., Fumino, S., Fujita, H., Okubo, T., Fujiwara, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26598152
Transient Neonatal Uterine Bleeding Offers a Window to Understanding Uterine Development
Habiba, M. A., Guo, S., & Benagiano, G. (2026) · Biomolecules · doi:10.3390/biom16101378
- Authors
- Ober, W. B., & Bernstein, J.
- Affiliations
- Harvard University (US)
- Venue
- PEDIATRICS
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1955-10-01
- Volume
- 16
- Issue
- 4
- Pages
- 445-460
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1502130144
- Cited by
- 87
- References
- 0
- Citations by year
- 2026: 1 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- endometrial secretory phase, atretic follicles, gonadotropic activity, progesterone, Arthus phenomenon, endometrial stroma, placental membranes
- MeSH terms
- Endometrium, Female, Humans, Infant, Infant, Newborn, Ovary
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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