The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Timing of Solid Food Introduction in Relation to Atopic Dermatitis and Atopic Sensitization: Results From a Prospective Birth Cohort Study
Abstract
OBJECTIVE. Prophylactic feeding guidelines recommend a delayed introduction of solid foods for the prevention of atopic diseases. Scientific evidence for this is scarce. This study investigates whether a delayed introduction of solids (past 4 months or 6 months) is protective against the development of atopic dermatitis (AD) and atopic sensitization when considering reverse causality. METHODS. Data from 2612 infants in an ongoing birth cohort study were analyzed at 2 years of age. Information on diet and on symptoms and diagnoses of AD was collected semiannually, and information on specific immunoglobulin E levels was collected at 2 years of age. RESULTS. Solid food introduction past the first 4 months of life decreased the odds of symptomatic AD but not for doctor-diagnosed AD, combined doctor-diagnosed and symptomatic AD, or atopic sensitization. Postponing the introduction beyond the sixth month of life was not protective in relation to either definition of AD or atopic sensitization. There was also no evidence for a protective effect of a delayed introduction of solids on AD and atopic sensitization in children of atopic parents. There was clear evidence for reverse causality between early skin or allergic symptoms and the introduction of solids. CONCLUSIONS. This study does not find evidence supporting a delayed introduction of solids beyond the sixth month of life for the prevention of AD and atopic sensitization. We cannot rule out that delaying the introduction of solids for the first 4 months of life might offer some protection. Measures to avoid reverse causality have to be considered in the conduction, analysis, and interpretation of cohort studies on the topic.
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Cites
Zeiger, R. S., & Heller, S. (1995) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(95)70074-9 · Cited by 539
Cited by
Breastfeeding and the use of human milk
BREASTFEEDING, S. O., Eidelman, A. I., Schanler, R. J., Johnston, M., Landers, S., Noble, L., Szucs, K., & Viehmann, L. (2012) · Pediatrics · doi:10.1542/peds.2011-3552 · Cited by 4,357
Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children.
Morgenstern, V., Zutavern, A., Cyrys, J., Brockow, I., Koletzko, S., Krämer, U., Behrendt, H., Herbarth, O., von Berg, A., Bauer, C. P., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-036oc · Cited by 567
Self-citationZutavern, A., Brockow, I., Schaaf, B., von Berg, A., Diez, U., Borte, M., Kraemer, U., Herbarth, O., Behrendt, H., Wichmann, H.-E., et al. (2008) · Pediatrics · doi:10.1542/peds.2006-3553 · Cited by 262
Self-citationCousminer, D. L., Berry, D. J., Timpson, N. J., Ang, W., Thiering, E., Byrne, E. M., Taal, H. R., Huikari, V., Bradfield, J. P., Kerkhof, M., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt104 · Cited by 209
Self-citationManagement of Atopic Dermatitis in the Pediatric Population
Krakowski, A. C., Eichenfield, L. F., & Dohil, M. A. (2008) · Pediatrics · doi:10.1542/peds.2007-2232 · Cited by 205
Metadata
- Authors
- Zutavern, A., Brockow, I., Schaaf, B., Bolte, G., von Berg, A., Diez, U., Borte, M., Herbarth, O., Wichmann, H.-E., Heinrich, J., & the LISA Study Group
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2006-02-01
- Volume
- 117
- Issue
- 2
- Pages
- 401-411
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2164018201
- Cited by
- 290
- References
- 1
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- closed
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