The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chromosomal Integration of Human Herpesvirus 6 Is the Major Mode of Congenital Human Herpesvirus 6 Infection
Abstract
OBJECTIVE. We examined the frequency and characteristics of chromosomally integrated human herpesvirus 6 among congenitally infected children. METHODS. Infants with and without congenital human herpesvirus 6 infection were prospectively monitored. Cord blood mononuclear cell, peripheral blood mononuclear cell, saliva, urine, and hair follicle samples were examined for human herpesvirus 6 DNA. Human herpesvirus 6 RNA, serum antibody, and chromosomally integrated human herpesvirus 6 levels were also assessed. RESULTS. Among 85 infants, 43 had congenital infections and 42 had postnatal infections. Most congenital infections (86%) resulted from chromosomally integrated human herpesvirus 6; 6 infants (14%) had transplacental infections. Children with chromosomally integrated human herpesvirus 6 had high viral loads in all sites (mean: 5–6 log10 genomic copies per μg of cellular DNA); among children with transplacental infection or postnatal infection, human herpesvirus 6 DNA was absent in hair samples and inconsistent in other samples, and viral loads were significantly lower. One parent of each child with chromosomally integrated human herpesvirus 6 who had parental hair samples tested had hair containing human herpesvirus 6 DNA. Variant A caused 32% of chromosomally integrated human herpesvirus 6 infections, compared with 2% of postnatal infections. Replicating human herpesvirus 6 was detected only among chromosomally integrated human herpesvirus 6 samples (8% of cord blood mononuclear cells and peripheral blood mononuclear cells). Cord blood human herpesvirus 6 antibody levels were similar among children with chromosomally integrated human herpesvirus 6, transplacental infection, and postnatal infection and between children with maternal and paternal chromosomally integrated human herpesvirus 6 transmission. CONCLUSIONS. Human herpesvirus 6 congenital infection results primarily from chromosomally integrated virus which is passed through the germ-line. Infants with chromosomally integrated human herpesvirus 6 had high viral loads in all specimens, produced human herpesvirus 6 antibody, and mRNA. The clinical relevance needs study as 1 of 116 newborns may have chromosomally integrated human herpesvirus 6 blood specimens.
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Citations
Cites
Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children
Caserta, M. T., McDermott, M. P., Dewhurst, S., Schnabel, K., Carnahan, J. A., Gilbert, L., Lathan, G., Lofthus, G. K., & Hall, C. B. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.016 · Cited by 95
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Cited by
Chromosomally integrated human herpesvirus 6: questions and answers
Pellett, P. E., Ablashi, D. V., Ambros, P. F., Agut, H., Caserta, M. T., Descamps, V., Flamand, L., Gautheret‐Dejean, A., Hall, C. B., Kamble, R. T., et al. (2012) · Reviews in Medical Virology · doi:10.1002/rmv.715 · Cited by 377
Self-citationLaboratory and Clinical Aspects of Human Herpesvirus 6 Infections
Agut, H., Bonnafous, P., & Gautheret-Dejean, A. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00122-14 · Cited by 345
Syndromic Panel-Based Testing in Clinical Microbiology
Ramanan, P., Bryson, A. L., Binnicker, M. J., Pritt, B. S., & Patel, R. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00024-17 · Cited by 308
Green, D. A., Pereira, M., Miko, B., Radmard, S., Whittier, S., & Thakur, K. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy288 · Cited by 110
Update on infections with human herpesviruses 6A, 6B, and 7
Agut, H., Bonnafous, P., & Gautheret-Dejean, A. (2017) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2016.09.004 · Cited by 96
Metadata
- Authors
- Hall, C. B., Caserta, M. T., Schnabel, K., Shelley, L. M., Marino, A. S., Carnahan, J. A., Yoo, C., Lofthus, G. K., & McDermott, M. P.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2008-09-01
- Volume
- 122
- Issue
- 3
- Pages
- 513-520
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2033763269
- Cited by
- 196
- References
- 1
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hall, C. B., Caserta, M. T., Schnabel, K., Shelley, L. M., Marino, A. S., Carnahan, J. A., Yoo, C., Lofthus, G. K., & McDermott, M. P. (2008). Chromosomal Integration of Human Herpesvirus 6 Is the Major Mode of Congenital Human Herpesvirus 6 Infection. Pediatrics. https://doi.org/10.1542/peds.2007-2838
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