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Cited by 79Preterm Birth and ChorioamnionitisPregnancy and preeclampsia studiesNeonatal and Maternal Infections

Placental Inflammatory Response Is Associated With Poor Neonatal Growth: Preterm Birth Cohort Study

Mestan, Karen, Yu, Yunxian, Matoba, Nana, Cerda, Sandra, Demmin, Bethany, Pearson, Colleen, Ortiz, Katherin, Wang, Xiaobin·2010·Pediatrics
DOI 10.1542/peds.2009-0313
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Abstract

OBJECTIVE: We sought to determine whether placental markers of intrauterine inflammation were associated with poor weight gain among premature infants in the neonatal period. METHODS: We reviewed 697 preterm births prospectively enrolled as part of an ongoing molecular epidemiological study. Placental markers and serial weight gain were analyzed for premature infants who were hospitalized for ≥21 days (N = 256). Placentas were examined for maternal inflammatory response (MIR), defined as subchorionitis, chorioamnionitis, deciduitis, or free membranitis, and fetal inflammatory response (FIR), defined as inflammation extending to the umbilical cord or chorionic plate. Multivariate linear regression and stratified analyses were performed. RESULTS: Decreases in weight gain at day 21 were associated with the presence of either MIR or FIR (β coefficient = −4.63 ± 1.41; P = .001). The association was stronger with FIR than MIR (P for trend = .0027) and persisted in the remaining hospitalized infants at day 28 (n = 223; β coefficient = −5.53 ± 1.85; P = .0028). Mean body weights were similar among the 3 groups by corrected age of 36 weeks or discharge, whichever came first. Associations between placental inflammation and poor growth persisted among infants with prenatal corticosteroid exposure and/or neonatal complications and remained marginally significant in the nonexposed groups. Among infants without intrauterine growth restriction, significant association persisted (n = 186; β coefficient = −5.68 ± 1.56; P = .0003). CONCLUSIONS: Placental inflammation is associated with poor neonatal growth. MIR and FIR may be useful markers for identifying infants at risk for postnatal growth failure.

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  • Elevated levels of placental inflammation have been associated independently with slower post-natal growth in pre-term infants, and so may have long-lasting effects for adult health.

    “Elevated levels of placental inflammation have been associated independently with slower post-natal growth in pre-term infants, and so may have long-lasting effects for adult health (377).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [377]

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Authors
Mestan, K., Yu, Y., Matoba, N., Cerda, S., Demmin, B., Pearson, C., Ortiz, K., & Wang, X.
Affiliations
  • Northwestern University (US)
  • Boston University (US)
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2010-04-01
Volume
125
Issue
4
Pages
e891-e898
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2009-0313
OpenAlex
W1972632653
Cited by
79
References
30
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 6 · 2021: 8 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 6
FWCI
4.89
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • March of Dimes Foundation
  • National Institutes of Health
  • National Institute of Environmental Health Sciences (R21ES011666, R21 ES11666)
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD41702, R01HD041702)
Topics
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
placental inflammation, fetal inflammatory response, maternal inflammatory response, preterm birth, neonatal growth, neonatal weight gain, chorioamnionitis, deciduitis, postnatal growth failure, antenatal corticosteroids, fetal growth restriction
MeSH terms
Adult, Failure to Thrive, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Premature, Diseases, Inflammation, Male, Placenta Diseases, Pregnancy, Pregnancy Complications, Infectious, Prospective Studies, Cohort Studies, Case-Control Studies, Premature Birth, Young Adult

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