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Cited by 126Effects and risks of endocrine disrupting chemicalsMale Breast Health StudiesSexual Differentiation and Disorders

Plasma Phthalate Levels in Pubertal Gynecomastia

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Durmaz, Erdem, Özmert, Elif N., Erkekoğlu, Pınar, Giray, Belma, Derman, Orhan, Hıncal, Filiz, Yurdakök, Kadriye·2010·Pediatrics
DOI 10.1542/peds.2009-0724
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Abstract

Objective Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases. Patients and methods The study group comprised 40 newly diagnosed pubertal gynecomastia cases who were admitted to Hacettepe University Ihsan Doğramaci Children's Hospital. The control group comprised 21 age-matched children without gynecomastia or other endocrinologic disorder. Plasma DEHP and MEHP levels were measured by using high-performance liquid chromatography. Serum hormone levels were determined in some pubertal gynecomastia cases according to the physician's evaluation. Results Plasma DEHP and MEHP levels were found to be statistically significantly higher in the pubertal gynecomastia group compared with the control group (P Conclusions DEHP, which has antiandrogenic or estrogenic effects, may be an etiologic factor in pubertal gynecomastia. These results may pioneer larger-scale studies on the etiologic role of DEHP in pubertal gynecomastia.

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Crossref · 10.1542/peds.2009-0724

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  • Significantly higher concentrations of DEHP (4.66 μg/mL) and MEHP (3.19 μg/mL) were found in the urine of 40 Turkish boys with gynecomastia as compared to control groups.

    “Significantly higher concentrations of DEHP (4.66 µg/mL) and MEHP (3.19 µg/mL) were found in the urine of 40 Turkish boys with gynecomastia as compared to that of control groups [207].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [207]

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Authors
Durmaz, E., Özmert, E. N., Erkekoğlu, P., Giray, B., Derman, O., Hıncal, F., & Yurdakök, K.
Affiliations
  • Departments of Pediatrics
  • Toxicology, Hacettepe University, Ankara, Turkey
  • Hacettepe University (TR)
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2010-01-01
Volume
125
Issue
1
Pages
e122-e129
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2009-0724
OpenAlex
W2147735900
Cited by
126
References
1
Citations by year
2025: 2 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 11 · 2013: 10 · 2012: 18
FWCI
8.02
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
  • Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Male Breast Health Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
pubertal gynecomastia, phthalates, DEHP, mono(2-ethylhexyl) phthalate, DEHP metabolites, endocrine disruptors, antiandrogenic effects, estrogenic effects, serum hormone levels
MeSH terms
Adolescent, Blood Chemical Analysis, Child, Diethylhexyl Phthalate, Environmental Exposure, Gynecomastia, Humans, Male, Phthalic Acids, Probability, Puberty, Radioimmunoassay, Reference Values, Turkey, Multivariate Analysis, Logistic Models, Case-Control Studies, Risk Assessment, Tandem Mass Spectrometry

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