Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet
Abstract
Objective Celiac disease (CD) is characterized by histologic alterations in small bowel biopsies. Circulating specific CD antibodies at the time of diagnosis and their disappearance after a gluten-free diet support the diagnosis of CD. We aimed to determine the behavior of the CD antibodies immunoglobulin A anti-tissue transglutaminase (anti-TG2) and immunoglobulin A endomysium (EMA) in children with CD after starting a gluten-free diet. Methods This was a retrospective multicenter study in the Netherlands between 2001 and 2009. Inclusion criteria were all newly diagnosed patients with CD younger than 19 years who had at least 1 anti-TG2 and/or EMA measurement before and after starting a gluten-free diet. Eight different anti-TG2 kits were used with substrates of guinea pig TG2 in 1 (Sigma) and 7 human-recombinant TG2: Varelisa and EliA Celikey Phadia-GmbH; Orgentec Diagnostica-GmbH; Diarect AG; Roboscreen GmbH; Aeskulisa Diagnostics; Binding Site Ltd. EMA was analyzed with indirect immunofluorescence tests. Statistical analyses were performed by using mixed-model repeated measurements and survival analysis. Results There were 129 children with CD included (mean age: 5.6 years; SD ± 4.2). The mean concentration of anti-TG2 decreased significantly within 3 months after starting a gluten-free diet (P Conclusions Doctors taking care of children with CD should be aware that the mean concentration of anti-TG2 will show a 74% decrease (95% confidence interval: 69%-79%) after 3 mont…
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On a gluten-free diet, IgA-TGA levels decrease over time and are expected to normalize by 18-24 months after starting the diet, depending on the serology kit used.
“On a GFD, IgA-TGA levels decrease over time and are expected to normalize by 18-24 months after starting the diet (84) depending on the serology kit used.”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [84]
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ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186 · see citing works
Self-citationAntitissue Transglutaminase Normalization Postdiagnosis in Children With Celiac Disease
Isaac, D. M., Rajani, S., Yaskina, M., Huynh, H. Q., & Turner, J. M. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001480 · Cited by 33 · see citing works
Sansotta, N., Alessio, M. G., Norsa, L., Previtali, G., Ferrari, A., Guerra, G., & D'Antiga, L. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002519 · Cited by 31 · see citing works
- Authors
- Esch, C. E. H., Wolters, V. M., Gerritsen, S. A. M., Putter, H., von Blomberg, B. M., van Hoogstraten, I. M. W., Houwen, R. H. J., van der Lely, N., & Mearin, M. L.
- Affiliations
- Departments of Pediatric Gastroenterology and
- University Medical Center Utrecht (NL)
- Leiden University Medical Center (NL)
- Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; and
- Department of Pediatrics, Reinier de Graaf Gasthuis, Delft, Netherlands
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2011-09-01
- Volume
- 128
- Issue
- 3
- Pages
- 547-552
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2157645205
- Cited by
- 49
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 5
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Keywords
- celiac disease, gluten-free diet, anti-tissue transglutaminase antibodies, anti-endomysial antibodies, seroconversion, children, immunoglobulin A
- MeSH terms
- Protein Glutamine gamma Glutamyltransferase 2, Antibodies, Anti-Idiotypic, Autoantibodies, Celiac Disease, Child, Child, Preschool, Female, Humans, Immunoglobulin A, Infant, Intestinal Mucosa, Male, Transglutaminases, Retrospective Studies, Fluorescent Antibody Technique, Indirect, GTP-Binding Proteins, Diet, Gluten-Free
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