The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Six Developmental Trajectories Characterize Children With Autism
Open accessAbstract
OBJECTIVE: The goal of this study was to describe the typical longitudinal developmental trajectories of social and communication functioning in children with autism and to determine the correlates of these trajectories. METHODS: Children with autism who were born in California from 1992 through 2001 and enrolled with the California Department of Developmental Services were identified. Subjects with <4 evaluations present in the database were excluded, resulting in a sample of 6975 children aged 2 to 14 years. Score sequences were constructed based on 9 evaluative items for social, communication, and repetitive behavior functioning. Typical trajectories were identified by using group-based latent trajectory modeling, and multinomial logistic regression models were used to determine the odds of classification within each trajectory varied by individual and family-level factors. RESULTS: Six typical patterns of social, communication, and repetitive behavior functioning were identified. These trajectories displayed significant heterogeneity in developmental pathways, and children whose symptoms were least severe at first diagnosis tended to improve more rapidly than those severely affected. One group of ∼10% of children experienced rapid gains, moving from severely affected to high functioning. Socioeconomic factors were correlated with trajectory outcomes; children with non-Hispanic, white, well-educated mothers were more likely to be high functioning, and minority children with less-educated mothers or intellectual disabilities were very unlikely to experience rapid gains. CONCLUSIONS: Children with autism have heterogeneous developmental pathways. One group of children evidenced remarkable developmental change over time. Understanding what drives these outcomes is thus critical.
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“Some individuals diagnosed as children have no clinically meaningful (or even detectable) impairment later in life (socalled 'optimal outcome' 141,142 )”
From Autism spectrum disorder (2020) · cites this paper as [142]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Primary and secondary disorders and disadvantage can accumulate through development in people with autism spectrum disorder (ASD).”
From Autism spectrum disorder (2020) · cites this paper as [142]
Experimental — accuracy not yet measuredIn the citing paper
“Most of the trajectories remained stable from 4 to 14 years, but with different levels of severity.”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [6]
In the citing paper
“Interestingly, about one in ten of children with ASD experienced rapid gains in communication and social abilities, moving from severely affected to high functioning ('bloomers').”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [6]
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“For example, 21.4% of the subjects never showed repetitive behaviors, and 8.1% presented with repetitive behaviors at age 3 but improved as they grew older ( Fig. 1 ).”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [6]
In the citing paper
“In a recent prospective study of 6,975 children with ASD followed from diagnosis through age 14, six distinct common trajectories of social, communication and repetitive behavior were identified 6 .”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [6]
In the citing paper
“For example, 21.4% of the subjects never showed repetitive behaviors, and 8.1% presented with repetitive behaviors at age 3 but improved as they grew older ( Fig. 1 ).”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [6]
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Metadata
- Authors
- Fountain, C., Winter, A. S., & Bearman, P. S.
- Affiliations
- Columbia University (US)
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2012-05-01
- Volume
- 129
- Issue
- 5
- Pages
- e1112-e1120
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- PMC
- PMC3340586
- OpenAlex
- W2145095299
- Cited by
- 372
- References
- 43
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 24 · 2023: 23 · 2022: 32 · 2021: 43 · 2020: 30 · 2019: 38 · 2018: 30 · 2017: 26 · 2016: 23 · 2015: 22 · 2014: 20 · 2013: 22 · 2012: 3
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PEDIATRICS (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institutes of Health (DP1OD003635)
- National Institute of Mental Health (R21MH096122)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- autism spectrum disorder, developmental trajectories, social functioning, repetitive behavior, developmental heterogeneity, trajectory classification, socioeconomic factors, maternal education, intellectual disability, developmental changes
- MeSH terms
- Adolescent, California, Child, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Communication, Female, Hispanic or Latino, Humans, Intelligence, Longitudinal Studies, Male, Social Behavior, Socioeconomic Factors, Statistics as Topic, Stereotyped Behavior, Models, Statistical, White People
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