Trends in Candida Central Line-Associated Bloodstream Infections Among NICUs, 1999–2009

Chitnis, Amit S.; Magill, Shelley S.; Edwards, Jonathan R.; Chiller, Tom M.; Fridkin, Scott K.; Lessa, Fernanda C.

doi:10.1542/peds.2011-3620

Cited by 78Antifungal resistance and susceptibilityCentral Venous Catheters and HemodialysisNeonatal and Maternal Infections

Trends in Candida Central Line-Associated Bloodstream Infections Among NICUs, 1999–2009

Chitnis, Amit S., Magill, Shelley S., Edwards, Jonathan R., Chiller, Tom M., Fridkin, Scott K., Lessa, Fernanda C.·2012·Pediatrics

DOI 10.1542/peds.2011-3620

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Abstract

OBJECTIVES: To assess trends in incidence of Candida spp. central line-associated bloodstream infections (CLABSIs) in US NICUs, 1999–2009. METHODS: Data from NICUs participating in the National Nosocomial Infections Surveillance (1999–2004) and National Healthcare Safety Network (2006–2009) were analyzed. Overall and birth weight-specific incidence rates of Candida spp. CLABSIs per 1000 central line-days were calculated. Trends in incidence were assessed by using Poisson regression, and trends in proportion of CLABSIs identified as Candida albicans were assessed by using weighted-linear regression. RESULTS: Overall, 398 NICUs reported 1407 Candida spp. CLABSIs (706 due to C albicans) among 1400 neonates. Of the 1400 neonates, 963 (69%) were ≤1000 g at the time of birth, and 182 (13%) died. From 1999 to 2009, the overall incidence decreased significantly for CLABSIs due to Candida spp. (0.92 vs 0.2), C albicans (0.53 vs 0.09), and non-albicans Candida spp. (0.39 vs 0.1). Birth weight-specific incidence significantly decreased across all birth weight categories for C albicans. For CLABSIs due to non-albicans Candida spp., significant decreases were detected among all birth weight categories, except among neonates 1501 to 2500 g. The proportion of Candida spp. CLABSIs due to C albicans did not significantly change over time, remaining at ∼50%. CONCLUSIONS: Incidence of Candida spp. CLABSIs decreased substantially among NICU patients, regardless of birth weight. Decreases in incidence across all birth weight categories, and not only among neonates ≤1000 g in whom antifungal prophylaxis may be more common, suggest that multiple factors contributed to the declining incidence.

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Other Candida species have been found together with Candida albicans in polymicrobial biofilms from patients.
“other Candida species have been found together with C. albicans in polymicrobial biofilms from patients (27).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [27]

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Authors: Chitnis, A. S., Magill, S. S., Edwards, J. R., Chiller, T. M., Fridkin, S. K., & Lessa, F. C.
Affiliations: Centers for Disease Control and Prevention (US)
Surveillance Branch, Division of Healthcare Quality Promotion, and
National Center for Emerging and Zoonotic Infectious Diseases (US)
Corresponding author: Chitnis, Amit S.
ORCID: Chitnis, Amit S.
Magill, Shelley S.
Edwards, Jonathan R.
Chiller, Tom M.
Fridkin, Scott K.
Lessa, Fernanda C.
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2012-07-01
Volume: 130
Issue: 1
Pages: e46-e52
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2011-3620
OpenAlex: W2138341813
Cited by: 78
References: 31
Citations by year: 2026: 3 · 2025: 5 · 2024: 9 · 2023: 1 · 2021: 3 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 12 · 2014: 13 · 2013: 6 · 2012: 1
FWCI: 7.04
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords: Candida, central line-associated bloodstream infection, neonatal intensive care unit, Candida albicans, non-albicans Candida, incidence trends, birth weight, antifungal prophylaxis, nosocomial infections, neonates
MeSH terms: Birth Weight, Candida albicans, Catheterization, Central Venous, Cross Infection, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Population Surveillance, Regression Analysis, United States, Incidence, Poisson Distribution, Linear Models, Infection Control, Catheter-Related Infections, Candidemia

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Trends in Candida Central Line-Associated Bloodstream Infections Among NICUs, 1999–2009

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